scholarly journals The hepatic architecture of the coelacanth differs from that of the lungfish in portal triad formation

2019 ◽  
Vol 96 (1) ◽  
pp. 1-11
Author(s):  
Nobuyoshi SHIOJIRI ◽  
Sho TANAKA ◽  
Hayato KAWAKAMI
Keyword(s):  
Portal Triad

Xanthine oxidase and superoxide radicals in portal triad crossclamping-induced microvascular reperfusion injury of the liver

1996 ◽  
Vol 21 (2) ◽  
pp. 189-197 ◽  
Author(s):  
Markus J. Müller ◽  
Brigitte Vollmar ◽  
Hans-Peter Friedl ◽  
Michael D. Menger
Keyword(s):  
Reperfusion Injury ◽  
Xanthine Oxidase ◽  
Superoxide Radicals ◽  
Portal Triad

Preserving hepatic artery flow during portal triad blood inflow occlusion reduces the outgrowth of hepatocarcinoma in mice after ischemia-reperfusion

2013 ◽  
Vol 44 (12) ◽  
pp. 1224-1233 ◽  
Author(s):  
Bin Shi ◽  
Chong Hui Li ◽  
Yong Wei Chen ◽  
Shi Zhong Yang ◽  
Ai Qun Zhang ◽  
...  
Keyword(s):  
Hepatic Artery ◽  
Ischemia Reperfusion ◽  
Portal Triad ◽  
Inflow Occlusion ◽  
Blood Inflow ◽  
Artery Flow

Development of Circulatory and Metabolic Shock Following Transient Portal Triad Occlusion

1995 ◽  
Vol 59 (5) ◽  
pp. 534-543 ◽  
Author(s):  
Mike E. Gonce ◽  
Daniel J. Brackett ◽  
Ronald A. Squires ◽  
Donald D. Gibson ◽  
Andre K. Balla ◽  
...  
Keyword(s):  
Portal Triad

IDIOPATHIC, RECURRENT CHOLESTASIS

PEDIATRICS ◽  
1970 ◽  
Vol 45 (5) ◽  
pp. 812-820
Author(s):  
Frederick B. Ruymann ◽  
Akio Takeuchi ◽  
H. Worth Boyce
Keyword(s):  
Age Of Onset ◽  
Serum Alkaline Phosphatase ◽  
Bile Canaliculi ◽  
Electron Microscopic ◽  
Portal Triad ◽  
Caucasian Girl ◽  
Younger Age ◽  
Oral Steroids ◽  
Liver Biopsies ◽  
Purpuric Rash

Idiopathic, recurrent cholestasis is characterized by episodes of obstructive jaundice often preceded by pruritus, steatorrhea, and purpuric rash. Between episodes of jaundice the liver histology is normal. We report a case of idiopathic, recurrent cholestasis occurring in a 14-year-old Caucasian girl who has experienced seven episodes of jaundice since 8 years of age. Serum alkaline phosphatase elevation preceded clinical jaundice. During remission the bromsulphalein excretion was normal. Response to oral steroids occurred when used after 4 weeks of jaundice. Cholestyramine resin and cyproheptadine relieved pruritus and in combination may have prevented progressive jaundice when administered early. Light microscopy during exacerbation showed centrilobular cholestasis with a slight mononuclear infiltration of the portal triad. The electron microscopic examinations demonstrate dilated bile canaliculi with altered microvilli. Serial liver biopsies over 6 years show no fibrosis or cytoplasmic alterations of hepatocytes. Of the 24 reported cases of idiopathic, recurrent cholestasis, two-thirds have been in males and had onset of jaundice under 20 years of age. This younger age of onset merits a greater awareness by the practicing pediatrician. After the diagnosis is established by clinical, biochemical, and morphologic studies, a benign course can be anticipated.

scholarly journals Preconditioning with L-alanyl-glutamine reduces hepatic ischemia-reperfusion injury in rats

2011 ◽  
Vol 26 (suppl 1) ◽  
pp. 8-13 ◽  
Author(s):  
Raimundo José Cunha Araújo Júnior ◽  
Raimundo Gerônimo da Silva Júnior ◽  
Marcelo Pinho Pessoa de Vasconcelos ◽  
Sérgio Botelho Guimarães ◽  
Paulo Roberto Leitão de Vasconcelos ◽  
...  
Keyword(s):  
Caspase 3 ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Control Group ◽  
Average Weight ◽  
Sham Operation ◽  
Hepatic Ischemia ◽  
Portal Triad ◽  
Hepatic Ischemia Reperfusion ◽  
Control Sham

PURPOSE: To evaluate the effects of pre-conditioning with L-alanyl- glutamine (L-Ala-Gln) in rats subjected to total hepatic ischemia. METHODS: Thirty Wistar rats, average weight 300g, were randomly assigned to 3 groups (n=10): G-1 - Saline, G-2- L-Ala-Gln, G-3-control (Sham). G-1 and G-3 groups were treated with saline 2.0 ml or L-Ala-Gln (0.75mg/Kg) intraperitoneally (ip) respectively, 2 hours before laparotomy. Anesthetized rats were subjected to laparotomy and total hepatic ischemia (30 minutes) induced by by clamping of portal triad. Control group underwent peritoneal puncture, two hours before the sham operation (laparotomy only). At the end of ischemia (G1 and G2), the liver was reperfused for 60 minutes. Following reperfusion blood samples were collected for evaluation of alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) levels. Liver (medium lobe) was removed for immunohistochemistry study with antibody for Caspase-3. RESULTS: It was found a significant decrease (p<0.05) of ALT levels (270.6 +40.8 vs 83.3 +5.5 - p <0.05), LDH (2079.0 +262.4 vs. 206.6 +16.2 - p <0.05) and Caspase-3 expression (6.72 +1.35 vs. 2.19 +1.14, p <0.05) in rats subjected to I / R, comparing the group treated with L-Ala -Gln with G-2. Also, the ALT level was significantly lower (P<0.05) in G-1 and G-2 groups than in G-3 (control group). CONCLUSION: L-Ala-Gln preconditioning in rats submitted to hepatic I/R significantly reduces ALT, LDH and Caspase-3 expression, suggesting hepatic protection.

Successful management of injuries to the portal triad

2019 ◽  
Vol 87 (1) ◽  
pp. 240-246
Author(s):  
K. Conley Coleman ◽  
Rachel L. Warner ◽  
James M. Bardes ◽  
Alison Wilson ◽  
Kenji Inaba ◽  
...  
Keyword(s):  
Successful Management ◽  
Portal Triad

Early surgical management of severe liver trauma with vascular complication can lead to early discharge

Trauma ◽  
2020 ◽  
Vol 22 (3) ◽  
pp. 233-236
Author(s):  
Ee Jun Ban ◽  
Belinda Hii ◽  
Marty Smith ◽  
Warren Clements
Keyword(s):  
Bile Duct ◽  
Liver Injury ◽  
Early Discharge ◽  
Vascular Complication ◽  
Liver Trauma ◽  
Multidisciplinary Management ◽  
Hepatic Trauma ◽  
Severe Liver ◽  
Portal Triad ◽  
Arterial Embolisation

Intrahepatic arterio-portal fistulas are rare complications of blunt hepatic trauma. We describe a case of a 35-year-old male sustaining blunt abdominal trauma resulting in a grade IV liver injury complicated by arterio-portal fistula, portal venous pseudoaneurysm and concomitant bile duct injury. Although arterial embolisation is the mainstay of treatment for arterio-portal fistula, we describe a rationale for early involvement of a hepatobiliary surgeon for multidisciplinary management. Hepatic resection for acute hepatic trauma can, in selected cases, promptly manage all elements of portal triad injury, and in this particular case facilitated early uncomplicated discharge.

Portal Triad Clamping Versus Vascular Exclusion for Vascular Control During Hepatic Resection: A Systematic Review and Meta-analysis

2008 ◽  
Vol 13 (3) ◽  
pp. 558-568 ◽  
Author(s):  
Nuh N. Rahbari ◽  
Moritz Koch ◽  
Arianeb Mehrabi ◽  
Kathrin Weidmann ◽  
Edith Motschall ◽  
...  
Keyword(s):  
Systematic Review ◽  
Hepatic Resection ◽  
Meta Analysis ◽  
Vascular Control ◽  
Portal Triad ◽  
Vascular Exclusion ◽  
Portal Triad Clamping

scholarly journals Intraportal versus Systemic Pentoxifylline Infusion after Normothermic Liver Ischemia: Effects on Regional Blood Flow Redistribution and Hepatic Ischemia-Reperfusion Injury

HPB Surgery ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Edson A. Ribeiro ◽  
Luiz F. Poli-de-Figueiredo ◽  
Rodrigo Vincenzi ◽  
Flavio H. F. Galvao ◽  
Nelson Margarido ◽  
...  
Keyword(s):  
Blood Flow ◽  
Ischemia Reperfusion Injury ◽  
Regional Blood Flow ◽  
Ischemia Reperfusion ◽  
Microcirculatory Blood Flow ◽  
Hepatic Ischemia ◽  
Portal Triad ◽  
Beneficial Effects ◽  
Hepatic Ischemia Reperfusion ◽  
Blood Flow Redistribution

Pentoxifylline (PTX) has been shown to have beneficial effects on microcirculatory blood flow. In this study we evaluate the potential hemodynamic and metabolic benefits of PTX during hepatic ischemia. We also test the hypothesis that portal PTX infusion can minimize the I/R injury when compared to systemic infusion. Methods. Twenty-four dogs ( kg) were subjected to portal triad occlusion (PTO) for 45 min. The animals were assigned to 3 groups: CT (control, PTO, ), PTX-syst (PTO + 25 mg/Kg of PTX IV, ), and PTX-pv (PTO + 25 mg/Kg of PTX in the portal vein, ). Animals were followed for 120 min. Systemic hemodynamics, gastrointestinal tract perfusion, oxygen-derived variables, and liver enzymes were evaluated throughout the experiment. Results. Animals treated with PTX presented significantly higher CO in the first hour after reperfusion, when compared to the CT (~3.7 vs. 2.1 L/min, ). Alanine aminotransferase (ALT) was similar in the PTX groups two hours after reperfusion but significantly higher in the CT (227 vs. ~64 U/L, ). Conclusion. PTX infusion was associated with hemodynamic benefits and was able to minimize liver injury during normothermic hepatic I/R. However, local PTX infusion was not associated with any significant advantage over systemic route.

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