scholarly journals Morphological Interrelationship Between Astrocytes and Nerve Endings in the Rat Spinal Trigeminal Nucleus Caudalis

2006 ◽  
Vol 83 (3) ◽  
pp. 91-96 ◽  
Author(s):  
Zhang YIHONG ◽  
Yoshitaka TAMADA ◽  
Keisuke AKAI ◽  
Fumihiko SUWA
Keyword(s):  
Nerve Endings ◽  
Spinal Trigeminal Nucleus ◽  
Trigeminal Nucleus ◽  
Trigeminal Nucleus Caudalis ◽  
Spinal Trigeminal Nucleus Caudalis

scholarly journals A Pre-Existing Myogenic Temporomandibular Disorder Increases Trigeminal Calcitonin Gene-Related Peptide and Enhances Nitroglycerin-Induced Hypersensitivity in Mice

2020 ◽  
Vol 21 (11) ◽  
pp. 4049
Author(s):  
Hui Shu ◽  
Sufang Liu ◽  
Yuanyuan Tang ◽  
Brian L. Schmidt ◽  
John C. Dolan ◽  
...  
Keyword(s):  
Protein Level ◽  
Temporomandibular Disorder ◽  
Calcitonin Gene Related Peptide ◽  
Spinal Trigeminal Nucleus ◽  
Trigeminal Nucleus ◽  
Systemic Injection ◽  
Trigeminal Nucleus Caudalis ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Spinal Trigeminal Nucleus Caudalis

Migraine is commonly reported among patients with temporomandibular disorders (TMDs), especially myogenic TMD. The pathophysiologic mechanisms related to the comorbidity of the two conditions remain elusive. In the present study, we combined masseter muscle tendon ligation (MMTL)-produced myogenic TMD with systemic injection of nitroglycerin (NTG)-induced migraine-like hypersensitivity in mice. Facial mechanical allodynia, functional allodynia, and light-aversive behavior were evaluated. Sumatriptan, an FDA-approved medication for migraine, was used to validate migraine-like hypersensitivity. Additionally, we examined the protein level of calcitonin gene-related peptide (CGRP) in the spinal trigeminal nucleus caudalis using immunohistochemistry. We observed that mice with MMTL pretreatment have a prolonged NTG-induced migraine-like hypersensitivity, and MMTL also enabled a non-sensitizing dose of NTG to trigger migraine-like hypersensitivity. Systemic injection of sumatriptan inhibited the MMTL-enhanced migraine-like hypersensitivity. MMTL pretreatment significantly upregulated the protein level of CGRP in the spinal trigeminal nucleus caudalis after NTG injection. Our results indicate that a pre-existing myogenic TMD can upregulate NTG-induced trigeminal CGRP and enhance migraine-like hypersensitivity.

scholarly journals Bilateral Descending Hypothalamic Projections to the Spinal Trigeminal Nucleus Caudalis in Rats

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e73022 ◽  
Author(s):  
Khaled Abdallah ◽  
Alain Artola ◽  
Lénaic Monconduit ◽  
Radhouane Dallel ◽  
Philippe Luccarini
Keyword(s):  
Spinal Trigeminal Nucleus ◽  
Trigeminal Nucleus ◽  
Trigeminal Nucleus Caudalis ◽  
Spinal Trigeminal Nucleus Caudalis
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