scholarly journals Quantitative Assessment of Mass Flow Boundaries in Continuous Twin-screw Granulation

2016 ◽  
Vol 70 (9) ◽  
pp. 604-609 ◽  
Author(s):  
Adrian Schmidt ◽  
Hans de Waard ◽  
Klaus-Peter Moll ◽  
Markus Krumme ◽  
Peter Kleinebudde
Keyword(s):  
Mass Flow ◽  
Quantitative Assessment ◽  
Twin Screw ◽  
Flow Boundaries ◽  
Twin Screw Granulation

scholarly journals The Influence of Equipment Design and Process Parameters on Granule Breakage in a Semi-Continuous Fluid Bed Dryer after Continuous Twin-Screw Wet Granulation

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 293
Author(s):  
Alexander Ryckaert ◽  
Michael Ghijs ◽  
Christoph Portier ◽  
Dejan Djuric ◽  
Adrian Funke ◽  
...  
Keyword(s):  
Process Development ◽  
Wet Granulation ◽  
Major Goal ◽  
Drying Time ◽  
Process Step ◽  
Manufacturing Line ◽  
Fluid Bed ◽  
Twin Screw ◽  
Filling Phase ◽  
Twin Screw Granulation

The drying unit of a continuous from-powder-to-tablet manufacturing line based on twin-screw granulation (TSG) is a crucial intermediate process step to achieve the desired tablet quality. Understanding the size reduction of pharmaceutical granules before, during, and after the fluid bed drying process is, however, still lacking. A first major goal was to investigate the breakage and attrition phenomena during transport of wet and dry granules, the filling phase, and drying phase on a ConsiGma-25 system (C25). Pneumatic transport of the wet granules after TSG towards the dryer induced extensive breakage, whereas the turbulent filling and drying phase of the drying cells caused rather moderate breakage and attrition. Subsequently, the dry transfer line was responsible for additional extensive breakage and attrition. The second major goal was to compare the influence of drying air temperature and drying time on granule size and moisture content for granules processed with a commercial-scale ConsiGma-25 system and with the R&D-scale ConsiGma-1 (C1) system. Generally, the granule quality obtained after drying with C1 was not predictive for the C25, making it challenging during process development with the C1 to obtain representative granules for the C25.

scholarly journals Investigations Concerning the Residence Time Distribution of Twin-Screw-Extrusion Processes as Indicator for Inherent Mixing

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 207 ◽  
Author(s):  
Jens Wesholowski ◽  
Andreas Berghaus ◽  
Markus Thommes
Keyword(s):  
Residence Time ◽  
Mass Flow ◽  
Time Distribution ◽  
Residence Time Distribution ◽  
Dispersion Model ◽  
Model Parameters ◽  
Twin Screw Extrusion ◽  
Characteristic Model ◽  
Screw Extrusion ◽  
Twin Screw

Over recent years Twin-Screw-Extrusion (TSE) has been established as a platform technology for pharmaceutical manufacturing. Compared to other continuous operation, one of the major benefits of this method is the combination of several unit operations within one apparatus. Several of these are linked to the Residence Time Distribution (RTD), which is typically expressed by the residence time density function. One relevant aspect for pharmaceutical processes is the mixing capacity, which is represented by the width of this distribution. In the frame of this study the influence of the mass flow, the temperature and the screw-barrel clearance were investigated for a constant barrel load (specific feed load, SFL). While the total mass flow as well as the external screw diameter affected the mixing performance, the barrel temperature had no influence for the investigated range. The determined results were additionally evaluated with respect to a fit to the Twin-Dispersion-Model (TDM). This model is based on the superimposition of two mixing functions. The correlations between varied process parameters and the obtained characteristic model parameters proved this general physical view on extrusion.

Twin screw granulation: Understanding the mechanism of granule formation along the barrel length

2016 ◽  
Vol 110 ◽  
pp. 43-53 ◽  
Author(s):  
Sushma V. Lute ◽  
Ranjit M. Dhenge ◽  
Michael J. Hounslow ◽  
Agba D. Salman
Keyword(s):  
Granule Formation ◽  
Twin Screw ◽  
Twin Screw Granulation

Continuous twin screw granulation: A complex interplay between formulation properties, process settings and screw design

2020 ◽  
Vol 576 ◽  
pp. 119004 ◽  
Author(s):  
Christoph Portier ◽  
Kenny Pandelaere ◽  
Urbain Delaet ◽  
Tamas Vigh ◽  
Giustino Di Pretoro ◽  
...  
Keyword(s):  
Complex Interplay ◽  
Screw Design ◽  
Twin Screw ◽  
Twin Screw Granulation

scholarly journals Twin screw granulation — A literature review

2015 ◽  
Vol 276 ◽  
pp. 89-102 ◽  
Author(s):  
Tim Chan Seem ◽  
Neil A. Rowson ◽  
Andy Ingram ◽  
Zhenyu Huang ◽  
Shen Yu ◽  
...  
Keyword(s):  
Literature Review ◽  
Twin Screw ◽  
Twin Screw Granulation

Melt granulation: A comparison of granules produced via high-shear mixing and twin-screw granulation

2020 ◽  
Vol 591 ◽  
pp. 119941
Author(s):  
Kristina E. Steffens ◽  
Marvin B. Brenner ◽  
Michael U. Hartig ◽  
Marius Monschke ◽  
Karl G. Wagner
Keyword(s):  
High Shear ◽  
Twin Screw ◽  
Shear Mixing ◽  
Twin Screw Granulation ◽  
Melt Granulation

Assessing Particle Segregation Using Near-Infrared Chemical Imaging in Twin Screw Granulation

2019 ◽  
Vol 568 ◽  
pp. 118541 ◽  
Author(s):  
Aquino L. Mundozah ◽  
Jiankai Yang ◽  
Claire C. Tridon ◽  
James J. Cartwright ◽  
Chalak S. Omar ◽  
...  
Keyword(s):  
Near Infrared ◽  
Chemical Imaging ◽  
Particle Segregation ◽  
Twin Screw ◽  
Twin Screw Granulation
Sign in / Sign up

Export Citation Format

Share Document