P5002 You say variation, they say mutation, we say confusion: Genetic communication, why it needs standardization!

2016 ◽  
Vol 94 (suppl_4) ◽  
pp. 116-116
Author(s):  
G. Sofronidis
Keyword(s):  
Genetic Communication

scholarly journals Hitting Times of Some Critical Events in RNA Origins of Life

Life ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1419
Author(s):  
Caleb Deen Bastian ◽  
Hershel Rabitz
Keyword(s):  
Formation Rate ◽  
Origins Of Life ◽  
Hitting Times ◽  
Spatial Proximity ◽  
High Fidelity ◽  
Critical Events ◽  
Random Drift ◽  
Genetic Communication ◽  
Low Dimensional ◽  
Channel Control

Can a replicase be found in the vast sequence space by random drift? We partially answer this question through a proof-of-concept study of the times of occurrence (hitting times) of some critical events in the origins of life for low-dimensional RNA sequences using a mathematical model and stochastic simulation studies from Python software. We parameterize fitness and similarity landscapes for polymerases and study a replicating population of sequences (randomly) participating in template-directed polymerization. Under the ansatz of localization where sequence proximity correlates with spatial proximity of sequences, we find that, for a replicating population of sequences, the hitting and establishment of a high-fidelity replicator depends critically on the polymerase fitness and sequence (spatial) similarity landscapes and on sequence dimension. Probability of hitting is dominated by landscape curvature, whereas hitting time is dominated by sequence dimension. Surface chemistries, compartmentalization, and decay increase hitting times. Compartmentalization by vesicles reveals a trade-off between vesicle formation rate and replicative mass, suggesting that compartmentalization is necessary to ensure sufficient concentration of precursors. Metabolism is thought to be necessary to replication by supplying precursors of nucleobase synthesis. We suggest that the dynamics of the search for a high-fidelity replicase evolved mostly during the final period and, upon hitting, would have been followed by genomic adaptation of genes and to compartmentalization and metabolism, effecting degree-of-freedom gains of replication channel control over domain and state to ensure the fidelity and safe operations of the primordial genetic communication system of life.

scholarly journals Comparative analysis of nuclear, chloroplast, and mitochondrial genomes of watermelon and melon provides evidence of gene transfer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Haonan Cui ◽  
Zhuo Ding ◽  
Qianglong Zhu ◽  
Yue Wu ◽  
Boyan Qiu ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Mitochondrial Genome ◽  
Chloroplast Genome ◽  
Genetic Material ◽  
Nuclear Genome ◽  
Plant Evolution ◽  
Total Length ◽  
Organelle Genomes ◽  
Nuclear Genomes ◽  
Genetic Communication

AbstractDuring plant evolution, there is genetic communication between organelle and nuclear genomes. A comparative analysis was performed on the organelle and nuclear genomes of the watermelon and melon. In the watermelon, chloroplast-derived sequences accounted for 7.6% of the total length of the mitochondrial genome. In the melon, chloroplast-derived sequences accounted for approximately 2.73% of the total mitochondrial genome. In watermelon and melon, the chloroplast-derived small-fragment sequences are either a subset of large-fragment sequences or appeared multiple times in the mitochondrial genome, indicating that these fragments may have undergone multiple independent migration integrations or emerged in the mitochondrial genome after migration, replication, and reorganization. There was no evidence of migration from the mitochondria to chloroplast genome. A sequence with a total length of about 73 kb (47%) in the watermelon chloroplast genome was homologous to a sequence of about 313 kb in the nuclear genome. About 33% of sequences in the watermelon mitochondrial genome was homologous with a 260 kb sequence in the nuclear genome. A sequence with a total length of about 38 kb (25%) in the melon chloroplast genome was homologous with 461 sequences in the nuclear genome, with a total length of about 301 kb. A 3.4 Mb sequence in the nuclear genome was homologous with a melon mitochondrial sequence. These results indicate that, during the evolution of watermelon and melon, a large amount of genetic material was exchanged between the nuclear genome and the two organelle genomes in the cytoplasm.

Genetic communication between fetus and mother: short- and long-term consequences

2007 ◽  
Vol 196 (4) ◽  
pp. 372-381 ◽  
Author(s):  
Wolfgang Holzgreve ◽  
Sinuhe Hahn ◽  
Xiao Yan Zhong ◽  
Olav Lapaire ◽  
Irene Hösli ◽  
...  
Keyword(s):  
Short And Long Term ◽  
Long Term Consequences ◽  
Genetic Communication
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