Chromosomal Aberrations in Cultured Porcine Fibroblasts after X-Irradiation of Male Progenitors2

1971 ◽  
Vol 32 (1) ◽  
pp. 1-9 ◽  
Author(s):  
D. L. Zartman ◽  
N. S. Fechheimer ◽  
L. N. Baker
Keyword(s):  
Chromosomal Aberrations ◽  
X Irradiation

PARACENTRIC INVERSIONS AND DETECTION OF SEX LINKED RECESSIVE LETHALS IN AEDES AEGYPTI

1970 ◽  
Vol 12 (3) ◽  
pp. 635-650 ◽  
Author(s):  
Satish C. Bhalla
Keyword(s):  
Aedes Aegypti ◽  
Genetic Control ◽  
Chromosomal Aberrations ◽  
The Other ◽  
Crossing Over ◽  
Partial Sterility ◽  
X Irradiation ◽  
Paracentric Inversions

Two sex linked paracentric inversions one on m chromosome, marked with bz (bronze body) and the other on M chromosome, marked with w (white eye), were artificially induced with X-irradiation and isolated. The inversions are designated as In. (1)1 and In. (1)2 respectively. The former is more than 23 units long and the later more than 16 units. Both suppress crossing over markedly and are associated with partial sterility. The two inversions are utilized as crossover suppressors in a technique designed for detecting sex linked recessive lethals. The technique works satisfactorily with certain limitations. The possibility of combining inversions with other chromosomal aberrations for genetic control of Aedes aegypti populations is suggested.

Preliminary study on chromosomal aberrations in eggs of mice fertilized in vitro after X-irradiation

1983 ◽  
Vol 121 (2) ◽  
pp. 125-130 ◽  
Author(s):  
Yoichi Matsuda ◽  
Takeshi Yamada ◽  
Izuo Tobari ◽  
Akiko Ohkawa
Keyword(s):  
Chromosomal Aberrations ◽  
X Irradiation ◽  
Preliminary Study

scholarly journals Effects of sodium butyrate on X-Ray and bleomycin-induced chromosome aberrations in human peripheral blood lymphocytes

1990 ◽  
Vol 56 (2-3) ◽  
pp. 267-276 ◽  
Author(s):  
K. Sankaranarayanan ◽  
A. v. Duyn ◽  
M. J. Loos ◽  
R. Meschini ◽  
A. T. Natarajan
Keyword(s):  
Sodium Butyrate ◽  
Chromosomal Aberrations ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
X Ray ◽  
Blood Lymphocytes ◽  
X Irradiation ◽  
Pre Treatment

SummaryPeripheral blood lymphocytes from normal human volunteers or from Down syndrome patients were pre-treated with sodium butyrate (a compound which is known to induce structural modifications in the chromatin through hyperacetylation of nucleosomal core histones) and exposed to X-irradiation or treated with bleomycin in vitro in the G0 and/or G1 stage(s) of the cell cycle. The frequencies of chromosomal aberrations in the first mitosis after treatment were scored.The results show an enhancement in the yield of aberrations in the butyrate pre-treated groups. However, the absolute frequencies of chromosomal aberrations as well as the relative increases with butyrate pre-treatment varied between blood samples from different donors suggesting the existence of inter-individual variations. There is a parallelism between the effects of X-irradiation or of combined treatments in G0 and G1 stages and between effects observed in the X-ray and bleomycin series. The increase in the yields of chromosomal aberrations in butyrate-treated and X-irradiated lymphocytes (relative to those which received X-irradiation alone) is interpreted as a consequence of the inhibition of repair of DNA damage by butyrate.

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