scholarly journals Genetic associations for gilt growth, compositional, and structural soundness traits with sow longevity and lifetime reproductive performance1

2013 ◽  
Vol 91 (4) ◽  
pp. 1570-1579 ◽  
Author(s):  
M. T. Nikkilä ◽  
K. J. Stalder ◽  
B. E. Mote ◽  
M. F. Rothschild ◽  
F. C. Gunsett ◽  
...  
Keyword(s):  
Genetic Associations ◽  
Sow Longevity

scholarly journals Identifying early indicator traits for sow longevity using a linear-threshold model in Thai Large White and Landrace females

2021 ◽  
Vol 34 (1) ◽  
pp. 20-25
Author(s):  
Suppasit Plaengkaeo ◽  
Monchai Duangjinda ◽  
Kenneth J. Stalder
Keyword(s):  
Litter Size ◽  
Genetic Parameters ◽  
Threshold Model ◽  
Genetic Associations ◽  
Genetic Trait ◽  
Large White ◽  
Linear Threshold ◽  
Sow Longevity ◽  
Linear Threshold Model ◽  
Indicator Traits

Objective: The objective of the study was to investigate the possibility of utilizing an early litter size trait as an indirect selection trait for longevity and to estimate genetic parameters between sow stayability and litter size at different parities using a linear-threshold model for longevity in Thai Large White (LW) and Landrace (LR) populations.Methods: The data included litter size at first, second, and third parities (NBA1, NBA2, and NBA3) and sow stayability from first to fourth farrowings (STAY14). The data was obtained from 10,794 LR and 9,475 LW sows. Genetic parameters were estimated using the multipletrait animal model. A linear-threshold model was used in which NBA1, NBA2, and NBA3 were continuous traits, while STAY14 was considered a binary trait.Results: Heritabilities for litter size were low and ranged from 0.01 to 0.06 for both LR and LW breeds. Similarly, heritabilities for stayability were low for both breeds. Genetic associations between litter size and stayability ranged from 0.43 to 0.65 for LR populations and 0.12 to 0.55 for LW populations. The genetic correlation between NBA1 and STAY14 was moderate and in a favorable direction for both LR and LW breeds (0.65 and 0.55, respectively).Conclusion: A linear-threshold model could be utilized to analyze litter size and sow stayability traits. Furthermore, selection for litter size at first parity, which was the genetic trait correlated with longevity, is possible when one attempts to improve lifetime productivity in Thai swine populations.

Erweiterung der Library of Genetic Associations – Update 2009

2009 ◽  
Vol 47 (01) ◽  
Author(s):  
M Krupp ◽  
T Maass ◽  
S Buchkremer ◽  
A Weinmann ◽  
F Thieringer ◽  
...  
Keyword(s):  
Genetic Associations

scholarly journals Genome-Wide Analysis of Sex Disparities in the Genetic Architecture of Lung and Colorectal Cancers

Genes ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 686
Author(s):  
Alireza Nazarian ◽  
Alexander M. Kulminski
Keyword(s):  
Nucleotide Polymorphisms ◽  
Genetic Associations ◽  
Significance Level ◽  
Association Analyses ◽  
Complex Disorders ◽  
Specific Effects ◽  
Genome Wide ◽  
Genetic Mechanisms ◽  
Sex Disparities ◽  
Almost All

Almost all complex disorders have manifested epidemiological and clinical sex disparities which might partially arise from sex-specific genetic mechanisms. Addressing such differences can be important from a precision medicine perspective which aims to make medical interventions more personalized and effective. We investigated sex-specific genetic associations with colorectal (CRCa) and lung (LCa) cancers using genome-wide single-nucleotide polymorphisms (SNPs) data from three independent datasets. The genome-wide association analyses revealed that 33 SNPs were associated with CRCa/LCa at P < 5.0 × 10−6 neither males or females. Of these, 26 SNPs had sex-specific effects as their effect sizes were statistically different between the two sexes at a Bonferroni-adjusted significance level of 0.0015. None had proxy SNPs within their ±1 Mb regions and the closest genes to 32 SNPs were not previously associated with the corresponding cancers. The pathway enrichment analyses demonstrated the associations of 35 pathways with CRCa or LCa which were mostly implicated in immune system responses, cell cycle, and chromosome stability. The significant pathways were mostly enriched in either males or females. Our findings provided novel insights into the potential sex-specific genetic heterogeneity of CRCa and LCa at SNP and pathway levels.

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