Single nucleotide polymorphism association study for backfat and intramuscular fat content in the region between SW2098 and SW1881 on pig chromosome 61

2012 ◽  
Vol 90 (4) ◽  
pp. 1081-1087 ◽  
Author(s):  
K. T. Lee ◽  
M. J. Byun ◽  
K. S. Kang ◽  
H. Hwang ◽  
E. W. Park ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Association Study ◽  
Intramuscular Fat ◽  
Fat Content ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Single Nucleotide Polymorphism Association ◽  
Intramuscular Fat Content

scholarly journals Effect of thyroglobulin gene polymorphism on the intramuscular fat content in cattle examined by x-ray computed tomography and Soxhlet methods

2013 ◽  
Vol 56 (1) ◽  
pp. 593-596
Author(s):  
I. Anton ◽  
A. Zsolnai ◽  
I. Holló ◽  
I. Repa ◽  
G. Holló
Keyword(s):  
Positive Association ◽  
Intramuscular Fat ◽  
Fat Content ◽  
Quality Trait ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Longissimus Dorsi Muscle ◽  
X Ray Computed ◽  
Thyroglobulin Gene ◽  
Intramuscular Fat Content

Abstract. Intramuscular fat content or marbling represents a valuable beef quality trait and is an important determinant of palatability due to its contribution to juiciness and flavour. Meat which has little marbling may be dry and flavourless. Higher levels of intramuscular fat have been associated with increased tenderness, juiciness and flavour of beef (Thompson 2004). Whereas this feature is highly appreciated in some markets (by example Australia, China, Korea, Japan) breeders usually try to increase intramuscular fat deposition in cattle by nutrition. However, genetic factors have been shown to affect marbling in cattle. Thyroglobulin (TG) is a glycoproteic hormone synthesised in the thyroid gland and is the precursor of triiodothyronine (T3) and thyroxine (T4) hormones which influence lipid metabolism. T3 and T4 hormones have been associated with marbling in Wagyu cattle (Mears et al. 2001). The effect of a C/T single nucleotide polymorphism in the 5'-untranslated region of TG gene has been concluded to affect intramuscular fat content in cattle (Barendse 1999). High probability of positive association between the T allele of bovine TG gene and marbling was observed by Wood et al. (2006). Thyroglobulin mainly affects the fat content of longissimus dorsi muscle (LD) (Thaller et al. 2003).

scholarly journals Nicholas Gordon Martin

2020 ◽  
Vol 23 (2) ◽  
pp. 72-73
Author(s):  
Georgia Chenevix-Trench
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Association Study ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Single Nucleotide Polymorphism Association

AbstractWe performed a candidate single-nucleotide polymorphism association study of cleft lip and palate in 1992 which earned more citations than it had subjects (N = 230).

scholarly journals Association of Twelve Candidate Gene Polymorphisms with the Intramuscular Fat Content and Average Backfat Thickness of Chinese Suhuai Pigs

Animals ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 858 ◽  
Author(s):  
Wang ◽  
Li ◽  
Zhou ◽  
Gao ◽  
Liu ◽  
...  
Keyword(s):  
Molecular Markers ◽  
Gene Polymorphisms ◽  
Genetic Correlations ◽  
Intramuscular Fat ◽  
Fat Content ◽  
Backfat Thickness ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Coefficients Of Variation ◽  
Intramuscular Fat Content

The present study aimed to identify the molecular markers for genes that influence intramuscular fat content (IFC), but not average backfat thickness (ABT). A total of 330 Suhuai pigs were slaughtered, and measurements of IFC and ABT were obtained. Phenotypic and genetic correlations between IFC and ABT were calculated. Thirteen single nucleotide polymorphisms (SNPs) among 12 candidate genes for IFC were analyzed, including FABP3, LIPE, IGF1, IGF2, LEP, LEPR, MC4R, PHKG1, RETN, RYR1, SCD, and UBE3C. Associations of the evaluated SNPs with IFCIFC and ABT were performed. Our results showed that the means of IFC and ABT were 1.99 ± 0.03 % and 26.68 ± 0.28 mm, respectively. The coefficients of variation (CVs) of IFC and ABT were 31.21% and 19.36%, respectively. The phenotypic and genetic correlations between IFC and ABT were moderate. Only the FABP3 (rs1110770079) was associated with IFC (p < 0.05) but not with ABT. Besides, there was a tendency for associations of RYR1 (rs344435545) and SCD (rs80912566) with IFC (p < 0.1). Our results indicated that the FABP3 (rs1110770079) SNP could be used as a marker to improve IFC without changing ABT in the Suhuai pig breeding system.

HLA-DRB1*1501 tagging rs3135388 polymorphism is not associated with neuromyelitis optica

2010 ◽  
Vol 16 (8) ◽  
pp. 981-984 ◽  
Author(s):  
Marcelo Matiello ◽  
Janet Schaefer-Klein ◽  
Doralina G Brum ◽  
Elizabeth J Atkinson ◽  
Orhun H Kantarci ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Single Nucleotide Polymorphism ◽  
Association Study ◽  
Neuromyelitis Optica ◽  
Genetic Association Study ◽  
Case Control ◽  
Small Populations ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Nuclease Assay

Background: Association of the HLA-DRB1*1501 allele with multiple sclerosis is well established, but its association with neuromyelitis optica has only been evaluated in small populations. Methods: We performed a case-control genetic association study to evaluate the association of HLA-DRB1*1501 with neuromyelitis optica. The single nucleotide polymorphism rs3135388, which tags HLA-DRB1*1501, was genotyped in 164 patients with neuromyelitis optica, 220 patients with multiple sclerosis and 959 controls matched for age, gender and ethnicity. Genotyping for rs3135388 was performed by Taqman-based 5' nuclease assay. Results: Rs3135388*A was positively associated with multiple sclerosis (OR = 3.93; 95% CI = 2.58—5.97, p = 1.18 × 10-09) but negatively associated with NMO (OR = 0.57; 95% CI = 0.36—0.91, p = 0.01). Conclusions: Multiple sclerosis and neuromyelitis optica differ in their associations with DRB1*1501.

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