scholarly journals Prediction of prion protein genotype and association of this genotype with lamb performance traits of Suffolk sheep1,2

2010 ◽  
Vol 88 (2) ◽  
pp. 428-434 ◽  
Author(s):  
R. M. Sawalha ◽  
B. Villanueva ◽  
S. Brotherstone ◽  
P. L. Rogers ◽  
R. M. Lewis
Keyword(s):  
Prion Protein ◽  
Performance Traits ◽  
Protein Genotype

Associations between the prion protein genotype and performance traits of meat breeds of sheep

2004 ◽  
Vol 155 (5) ◽  
pp. 140-143 ◽  
Author(s):  
F. de Vries ◽  
N. Hamann ◽  
C. Drögemüller ◽  
O. Distl ◽  
N. Borchers ◽  
...  
Keyword(s):  
Prion Protein ◽  
Performance Traits ◽  
And Performance ◽  
Protein Genotype

Allelic variations in apolipoprotein E and prion protein genotype related to plaque formation and age of onset in sporadic Creutzfeldt-Jakob disease

1995 ◽  
Vol 187 (2) ◽  
pp. 127-129 ◽  
Author(s):  
Stuart M. Pickering-Brown ◽  
David M.A. Mann ◽  
Frank Owen ◽  
James W. Ironside ◽  
Rajith de Silva ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Prion Protein ◽  
Age Of Onset ◽  
Plaque Formation ◽  
Jakob Disease ◽  
Allelic Variations ◽  
Protein Genotype

scholarly journals Comparison of the ovine prion protein genotype profiles of breeds Tigaie with Black Head and Merino

2013 ◽  
Vol 37 ◽  
pp. 625-630
Author(s):  
Stelian BARAITAREANU ◽  
Maria Rodica OTELEA ◽  
Mihaela ZAULET ◽  
Kurt SCHNEIDER ◽  
Mihai TURCITU ◽  
...  
Keyword(s):  
Prion Protein ◽  
Black Head ◽  
Protein Genotype

Analysis of associations between the prion protein genotype and reproduction traits in meat sheep breeds

2004 ◽  
Vol 79 (3) ◽  
pp. 397-404 ◽  
Author(s):  
F. de Vries ◽  
H. Hamann ◽  
C. Drögemüller ◽  
M. Ganter ◽  
O. Distl
Keyword(s):  
Animal Models ◽  
Prion Protein ◽  
General Analysis ◽  
Data Set ◽  
Sheep Breeds ◽  
Genotype Effect ◽  
Reproduction Traits ◽  
Meat Sheep ◽  
Protein Genotype ◽  
Suffolk Sheep

AbstractThe objective of this study was to analyse the associations between ovine prion protein (PrP) genotypes and reproduction traits in three German meat sheep breeds. Reproduction traits were age at first early lambing, age at first late lambing, first lambing interval, second lambing interval and total number of lambs born. The data set included 595 genotyped German Texel sheep among 5225 recorded sheep, 351 genotyped German Black-Headed Mutton among 10 177 sheep and 282 genotyped Suffolk sheep among 2849 sheep. Linear animal models were employed for the analysis of the PrP-genotype effect. The PrP-genotype effect was analysed by comparing the most frequent PrP genotypes ARR/ARR, ARR/ARQ, and ARQ/ARQ. In a more general analysis three PrP genotype classes of animals with two, one or no copy of the ARR allele were compared.In most cases, no significant associations were found between the PrP genotypes and the reproduction traits investigated. Only for the traits age at first early lambing in German Texel and second lambing interval in German Black-Headed Mutton and Suffolk could a significant association with the PrP genotype be observed.

scholarly journals Associations between lamb survival and prion protein genotype: analysis of data for ten sheep breeds in Great Britain

2009 ◽  
Vol 5 (1) ◽  
pp. 3 ◽  
Author(s):  
Simon Gubbins ◽  
Charlotte J Cook ◽  
Kieran Hyder ◽  
Kay Boulton ◽  
Carol Davis ◽  
...  
Keyword(s):  
Great Britain ◽  
Prion Protein ◽  
Sheep Breeds ◽  
Genotype Analysis ◽  
Lamb Survival ◽  
Protein Genotype

Thalamic form of Creutzfeldt-Jakob disease or fatal insomnia? Report of a sporadic case with normal prion protein genotype

1997 ◽  
Vol 93 (3) ◽  
pp. 317-322 ◽  
Author(s):  
Koichi Kawasaki ◽  
Koichi Wakabayashi ◽  
Akio Kawakami ◽  
Masami Higuchi ◽  
Tetsuyuki Kitamoto ◽  
...  
Keyword(s):  
Prion Protein ◽  
Sporadic Case ◽  
Jakob Disease ◽  
Protein Genotype

Neuropathological phenotype and ‘prion protein’ genotype correlation in sporadic Creutzfeldt-Jakob disease

1994 ◽  
Vol 179 (1-2) ◽  
pp. 50-52 ◽  
Author(s):  
Rajith de Silva ◽  
James W Ironside ◽  
Linda McCardle ◽  
Thomas Esmonde ◽  
Jeanne Bell ◽  
...  
Keyword(s):  
Prion Protein ◽  
Jakob Disease ◽  
Protein Genotype ◽  
Genotype Correlation

scholarly journals Erratum: Homozygous prion protein genotype predisposes to sporadic Creutzfeldt–Jakob disease

Nature ◽  
1991 ◽  
Vol 352 (6335) ◽  
pp. 547-547
Author(s):  
Mark S. Palmer ◽  
Aidan J. Dryden ◽  
J. Trevor Hughes ◽  
John Collinge
Keyword(s):  
Prion Protein ◽  
Jakob Disease ◽  
Protein Genotype

scholarly journals Risk of scrapie in British sheep of different prion protein genotype

2004 ◽  
Vol 85 (9) ◽  
pp. 2735-2740 ◽  
Author(s):  
M. Baylis ◽  
C. Chihota ◽  
E. Stevenson ◽  
W. Goldmann ◽  
A. Smith ◽  
...  
Keyword(s):  
Great Britain ◽  
Prion Protein ◽  
Lower Risk ◽  
Disease Risk ◽  
Published Data ◽  
Moderate Risk ◽  
Risk Of Death ◽  
Protein Genotype

There is a well-established association between sheep prion protein (PrP) genotype and the risk of death from scrapie. Certain genotypes are clearly associated with susceptibility to the disease and others to resistance. However, there have been no attempts to quantify the disease risk for all 15 PrP genotypes. Here, datasets of the PrP genotypes of nearly 14 000 British sheep and of more than 1500 confirmed scrapie cases were combined to yield an estimate of scrapie risk (reported cases per annum per million sheep of the genotype, or RCAM) for British sheep. The greatest scrapie risk by far, ranging from 225 to 545 RCAM, was for the VRQ-encoding genotypes ARQ/VRQ, ARH/VRQ and VRQ/VRQ. The next greatest risk (37 RCAM) was for the ARQ/ARQ genotype. The ARR/ARR genotype was the only numerically significant genotype for which no scrapie cases have been reported. The AHQ allele conferred resistance and the risk of scrapie in AHQ/VRQ sheep was very low (0·7 RCAM), although there was a higher and moderate risk for the AHQ homozygote (5 RCAM). The ARH allele appeared to confer susceptibility when encoded with VRQ, but possible resistance when encoded with other alleles. Scrapie risk varied with age: for VRQ/VRQ and ARH/VRQ the risk peaked at 2 years of age; that for ARQ/VRQ peaked at 3 years. There was some evidence that, following the lower risk at 4 and 5 years, a second rise occurred from about 6 years. Comparison with other published data indicated that the scrapie risk of certain PrP genotypes may differ between Great Britain and other countries.

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