Refined mapping of twinning-rate quantitative trait loci on bovine chromosome 5 and analysis of insulin-like growth factor-1 as a positional candidate gene1

2009 ◽  
Vol 87 (3) ◽  
pp. 835-843 ◽  
Author(s):  
E.-S. Kim ◽  
X. Shi ◽  
O. Cobanoglu ◽  
K. Weigel ◽  
P. J. Berger ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Growth Factor ◽  
Quantitative Trait ◽  
Bovine Chromosome ◽  
Insulin Like Growth Factor ◽  
Chromosome 5 ◽  
Positional Candidate ◽  
Trait Loci

Quantitative trait loci for insulin-like growth factor I, leptin, thyroxine, and corticosterone in genetically heterogeneous mice

2003 ◽  
Vol 15 (1) ◽  
pp. 44-51 ◽  
Author(s):  
James M. Harper ◽  
Andrzej T. Galecki ◽  
David T. Burke ◽  
Stephen L. Pinkosky ◽  
Richard A. Miller
Keyword(s):  
Quantitative Trait Loci ◽  
Growth Factor ◽  
Quantitative Trait ◽  
Chromosome 1 ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Genotype Information ◽  
Igf I ◽  
Trait Loci ◽  
Growth Factor I

Genotype information was collected at 87 loci in a group of 1,108 UM-HET3 mice bred as the progeny of [BALB/cJ × C57BL/6J]F1 mothers and [C3H/HeJ × DBA/2J]F1 fathers, for which thyroxine (T4), insulin-like growth factor I (IGF-I), and leptin levels had been measured at 4 and 15 mo of age. The data provided significant evidence for quantitative trait loci (QTL) modulating IGF-I levels on chromosomes 1, 3, 8, 10, and 17; for loci affecting T4 on chromosomes 4, 15, and 17; and for leptin on chromosome 3. Fecal levels of corticosterone at 17 mo of age were influenced by a QTL on chromosome 1. Nine other gene/hormone associations reached a nominal P < 0.01, providing suggestive but not statistical evidence for additional QTL. QTL with an influence on a given hormone were in nearly all cases additive, with little or no evidence for epistasis. Of the 12 strongest QTL, 5 had effects that were age dependent, having more effect in 15-mo-old than in 4-mo-old mice in all but one case; the other QTL had effects that were apparently age-independent. These results show that the genetic controls over late-life hormone levels are complex and dependent on effects of genes that act both early and late in the life course.

Mapping quantitative trait loci for serum insulin-like growth factor-1 levels in mice

Bone ◽  
2000 ◽  
Vol 27 (4) ◽  
pp. 521-528 ◽  
Author(s):  
C.J Rosen ◽  
G.A Churchill ◽  
L.R Donahue ◽  
K.L Shultz ◽  
J.K Burgess ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Growth Factor ◽  
Quantitative Trait ◽  
Serum Insulin ◽  
Insulin Like Growth Factor ◽  
Trait Loci

scholarly journals The Genetic Basis of Plasma Variation in Adiponectin, a Global Endophenotype for Obesity and the Metabolic Syndrome

2001 ◽  
Vol 86 (9) ◽  
pp. 4321-4325 ◽  
Author(s):  
Anthony G. Comuzzie ◽  
Tohru Funahashi ◽  
Gabriele Sonnenberg ◽  
Lisa J. Martin ◽  
Howard J. Jacob ◽  
...  
Keyword(s):  
Quantitative Trait Locus ◽  
Quantitative Trait Loci ◽  
Genetic Analysis ◽  
Quantitative Trait ◽  
European Ancestry ◽  
Chromosome 5 ◽  
Lod Score ◽  
The Metabolic Syndrome ◽  
Trait Loci ◽  
Trait Locus

Here we present the first genetic analysis of adiponectin levels, a newly identified adipocyte-derived protein. Recent work has suggested that adiponectin may play a role in mediating the effects of body weight as a risk factor for coronary artery disease. For this analysis we assayed serum levels of adiponectin in 1100 adults of predominantly northern European ancestry distributed across 170 families. Quantitative genetic analysis of adiponectin levels detected an additive genetic heritability of 46%. The maximum LOD score detected in a genome wide scan for adiponectin levels was 4.06 (P = 7.7 × 10−6), 35 cM from pter on chromosome 5. The second largest LOD score (LOD = 3.2; P = 6.2 × 10−5) was detected on chromosome 14, 29 cM from pter. The detection of a significant linkage with a quantitative trait locus on chromosome 5 provides strong evidence for a replication of a previously reported quantitative trait locus for obesity-related phenotypes. In addition, several secondary signals offer potential evidence of replications for additional previously reported obesity-related quantitative trait loci on chromosomes 2 and 10. Not only do these results identify quantitative trait loci with significant effects on a newly described, and potentially very important, adipocyte-derived protein, they also reveal the emergence of a consistent pattern of linkage results for obesity-related traits across a number of human populations.

Fine mapping of quantitative trait loci for mastitis resistance on bovine chromosome 11

2009 ◽  
Vol 40 (4) ◽  
pp. 509-515 ◽  
Author(s):  
N. F. Schulman ◽  
G. Sahana ◽  
T. Iso-Touru ◽  
M. S. Lund ◽  
L. Andersson-Eklund ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Fine Mapping ◽  
Quantitative Trait ◽  
Bovine Chromosome ◽  
Chromosome 11 ◽  
Trait Loci

scholarly journals Quantitative trait loci on chromosome 5 for susceptibility to frequency-specific effects on hearing in DBA/2J mice

2015 ◽  
Vol 64 (3) ◽  
pp. 241-251 ◽  
Author(s):  
Sari SUZUKI ◽  
Masashi ISHIKAWA ◽  
Takuya UEDA ◽  
Yasuhiro OHSHIBA ◽  
Yuki MIYASAKA ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Chromosome 5 ◽  
Specific Effects ◽  
Trait Loci

scholarly journals Quantitative trait loci affecting milk production traits on bovine chromosome 6 in zebuine Gyr breed

2011 ◽  
Vol 94 (2) ◽  
pp. 971-980 ◽  
Author(s):  
A.A. Silva ◽  
A.L.S. Azevedo ◽  
R.S. Verneque ◽  
K. Gasparini ◽  
M.G.C.D. Peixoto ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Milk Production ◽  
Quantitative Trait ◽  
Bovine Chromosome ◽  
Chromosome 6 ◽  
Production Traits ◽  
Milk Production Traits ◽  
Trait Loci
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