1640 Rumen protozoal communities are dynamic after a dietary switch from conserved forage to pasture

2016 ◽  
Vol 94 (suppl_5) ◽  
pp. 799-799
Author(s):  
M. L. Bainbridge ◽  
L. K. Saldinger ◽  
J. W. Barlow ◽  
J. P. Alvez ◽  
J. Roman ◽  
...  
Keyword(s):  
Author(s):  
Mélanie Fouesnard ◽  
Johanna Zoppi ◽  
Mélanie Petera ◽  
Léa Le Gleau ◽  
Carole Migné ◽  
...  

2021 ◽  
Vol 8 ◽  
Author(s):  
Antonia RuJia Sun ◽  
Xiaoxin Wu ◽  
Ross Crawford ◽  
Hongxing Li ◽  
Lin Mei ◽  
...  

Obesogenic diets contribute to the pathology of osteoarthritis (OA) by altering systemic and local metabolic inflammation. Yet, it remains unclear how quickly and reproducibly the body responds to weight loss strategies and improve OA. In this study we tested whether switching obese diet to a normal chow diet can mitigate the detrimental effects of inflammatory pathways that contribute to OA pathology. Male C57BL/6 mice were first fed with obesogenic diet (high fat diet) and switched to normal chow diet (obese diet → normal diet) or continued obese diet or normal diet throughout the experiment. A mouse model of OA was induced by surgical destabilization of the medial meniscus (DMM) model into the knee joint. Outcome measures included changes in metabolic factors such as glucose, insulin, lipid, and serum cytokines levels. Inflammation in synovial biopsies was scored and inflammation was determined using FACs sorted macrophages. Cartilage degeneration was monitored using histopathology. Our results indicate, dietary switching (obese diet → normal diet) reduced body weight and restored metabolic parameters and showed less synovial tissue inflammation. Systemic blood concentrations of pro-inflammatory cytokines IL-1α, IL-6, IL-12p40, and IL-17 were decreased, and anti-inflammatory cytokines IL-4 and IL-13 were increased in dietary switch group compared to mice that were fed with obesogenic diet continuously. Although obese diet worsens the cartilage degeneration in DMM OA model, weight loss induced by dietary switch does not promote the histopathological changes of OA during this study period. Collectively, these data demonstrate that switching obesogenic diet to normal improved metabolic syndrome symptoms and can modulate both systemic and synovium inflammation levels.


2019 ◽  
Vol 44 (2) ◽  
pp. 127-132 ◽  
Author(s):  
Yen-Ming Chan ◽  
Susanne Aufreiter ◽  
Stephen J. O’Keefe ◽  
Deborah L. O’Connor

How dietary patterns impact colonic bacterial biosynthesis of vitamins and utilization by humans is poorly understood. Our aim was to investigate whether a reciprocal dietary switch between rural South Africans (traditionally high fibre, low fat) and African Americans (Western diet of low fibre, high fat) affects colonic folate synthesis. Colonic evacuants were obtained from 20 rural South Africans and 20 African Americans consuming their usual diets at baseline. For 2 weeks thereafter, rural South Africans were provided with a Western diet (protein, 27%; fat, 52%; carbohydrate, 20%; and fibre, 8 g/day) and African Americans were provided with a high fibre, low-fat diet (protein, 16%; fat, 17%; carbohydrate, 63%; and fibre, 43 g/day). Colonic evacuants were again collected. No difference between groups at baseline in the folate content of 3-h evacuants was observed. The high-fibre, low-fat diet consumed by African Americans during the intervention produced a 41% increase in mean total folate content compared with baseline values (p = 0.0037). No change was observed in rural South Africans consuming a Western diet. Mean total folate content of colonic evacuants was higher among African Americans at the end of the dietary switch (3107 ± 1811 μg) compared with rural South Africans (2157 ± 1956 μg) (p = 0.0409). In conclusion, consistent with animal studies, switching from a Western diet to one higher in fibre and lower in fat can be expected to result in greater colonic folate content. Future research should confirm that these observations are not transitory and understand the contribution of transit-time to the findings.


2010 ◽  
Vol 20 (11) ◽  
pp. 1006-1011 ◽  
Author(s):  
Misha A. Vargas ◽  
Ningguang Luo ◽  
Atsushi Yamaguchi ◽  
Pankaj Kapahi
Keyword(s):  

Aging ◽  
2014 ◽  
Vol 6 (5) ◽  
pp. 355-368 ◽  
Author(s):  
Rachel Whitaker ◽  
M. Pilar Gil ◽  
Feifei Ding ◽  
Marc Tatar ◽  
Stephen L. Helfand ◽  
...  

2020 ◽  
Vol 40 ◽  
pp. 461-462
Author(s):  
M. Fouesnard ◽  
J. Zoppi ◽  
M. Petera ◽  
L. Le Gleau ◽  
C. Migne ◽  
...  

2013 ◽  
Vol 46 ◽  
pp. 48-55 ◽  
Author(s):  
Graeme Shannon ◽  
Robin L. Mackey ◽  
Rob Slotow

Sign in / Sign up

Export Citation Format

Share Document