1072 Evaluation of immune function of circulating leukocytes during the transition period in dairy cows

2016 ◽  
Vol 94 (suppl_5) ◽  
pp. 513-514
Author(s):  
A. Minuti ◽  
N. Jahan ◽  
F. Piccioli-Capelli ◽  
L. Bomba ◽  
S. Capomaccio ◽  
...  
Keyword(s):  
Immune Function ◽  
Dairy Cows ◽  
Transition Period

Evaluation of circulating leukocyte transcriptome and its relationship with immune function and blood markers in dairy cows during the transition period

2019 ◽  
Vol 20 (2) ◽  
pp. 293-305 ◽  
Author(s):  
Andrea Minuti ◽  
Nusrat Jahan ◽  
Vincenzo Lopreiato ◽  
Fiorenzo Piccioli-Cappelli ◽  
Lorenzo Bomba ◽  
...  
Keyword(s):  
Immune Function ◽  
Dairy Cows ◽  
Transition Period

scholarly journals Effects of 25-Hydroxyvitamin D3 and Oral Calcium Bolus on Lactation Performance, Ca Homeostasis, and Health of Multiparous Dairy Cows

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1576
Author(s):  
Hongjian Xu ◽  
Quanyu Zhang ◽  
Lihua Wang ◽  
Chengrui Zhang ◽  
Yang Li ◽  
...  
Keyword(s):  
Immune Function ◽  
Dairy Cows ◽  
Vitamin D3 ◽  
Transition Period ◽  
Lactation Performance ◽  
Necrosis Factor Alpha ◽  
Oral Calcium ◽  
Tnf Α ◽  
Total Antioxidant ◽  
Ca Homeostasis

Little information is available regarding the effect of supplementing 25-hydroxyvitamin D3 during the transition period combined with a postpartum oral calcium bolus on Ca homeostasis. The objectives of the current study were to evaluate the effects of 25-hydroxyvitamin D3 combined with postpartum oral calcium bolus on lactation performance, serum minerals and vitamin D3 metabolites, blood biochemistry, and antioxidant and immune function in multiparous dairy cows. To evaluate the effects of 25-hydroxyvitamin D3 combined with oral calcium, 48 multiparous Holstein cows were randomly assigned to one of four treatments: (1) supplementing 240 mg/day vitamin D3 without a postpartum oral Ca bolus (control), (2) supplementing 240 mg/day vitamin D3 with an oral Ca bolus containing 90 g of Ca immediately post-calving (Ca + VitD), (3) supplementing 6 g/day 25-hydroxyvitamin D3 without an oral Ca bolus (25D), and (4) supplementing 6 g/day 25-hydroxyvitamin D3 with an oral Ca bolus containing 90 g of Ca immediately post-calving (Ca + 25D). Lactation performance during the first 21 days was measured. Blood was collected at the initiation of calving and then 1, 2, 7, 14, and 21 days relative to the calving date. The yield of milk (0.05 < p < 0.10), energy-corrected milk (p < 0.05), 3.5% fat-corrected milk (p < 0.05), and milk protein (p < 0.05) were significantly higher in 25-hydroxyvitamin D3-treated groups within 3 weeks of lactation than in vitamin D3-treated cows. The iCa (p < 0.05) and tCa (p < 0.05) were higher in both Ca and 25D + Ca cows than in the control and 25D groups within 48 h. The concentrations of serum tCa (p < 0.05), tP (p < 0.05), and 25-hydroxyvitamin D3 (p < 0.05) in 25D and 25D + Ca cows were higher than those in control and Ca cows within 21 days postpartum. Feeding 25-hydroxyvitamin D3 also showed a lower concentration of malondialdehyde (p < 0.05), interleukin 6 (p < 0.05), and tumor necrosis factor-alpha (TNF-α) (p < 0.05), as well as a higher concentration of alkaline phosphatase (p < 0.05), total antioxidant capacity (p < 0.05), and immunoglobulin G (p < 0.05) than vitamin D3. Supplementing Ca bolus also showed lower concentrations of alanine transaminase (p < 0.05) and TNF-α (p < 0.05). In conclusion, supplementing 25-hydroxyvitamin D3 during the transition period combined with a postpartum oral calcium bolus improved lactation performance, Ca homeostasis, and antioxidant and immune function of medium-production dairy cows within 21 days postpartum.

256 Effects of Transition Period Nutrition on Uterine Health

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 136-137
Author(s):  
Felipe Cardoso
Keyword(s):  
Immune Function ◽  
Dairy Cows ◽  
Transition Period ◽  
Neutrophil Infiltration ◽  
High Energy ◽  
Polymorphonuclear Neutrophil ◽  
Blood Concentrations ◽  
Nonesterified Fatty Acids ◽  
Junction Protein ◽  
Uterine Health

Abstract The transition from gestation to lactation, also known as the transition period, is a critical time for dairy cows. This phase is typically defined as 3 wk before parturition through 3 wk after parturition. Peak disease incidence (shortly after parturition) corresponds with the time of greatest negative energy balance (NEB), the peak in blood concentrations of nonesterified fatty acids, and the greatest acceleration of milk yield. Decreased fertility in the face of increasing milk production may be attributable to greater severity of postpartal NEB resulting from inadequate transition management or increased rates of disease. The depth and duration of NEB is highly related to dry matter intake. Formulation and delivery of appropriate diets that limit total energy intake to requirements but also provide proper intakes of all other nutrients (including the most limiting amino acids Met and Lys) before calving can help lessen the extent of NEB after calving. Cows that received controlled-energy diets during the last 3 wk prepartum had shorter days to pregnancy than cows that consumed high-energy diets in this time period. Additionally, a fully acidified prepartum diet formulated with a higher Ca concentration improved reproductive performance and uterine immune function in the postpartum period through the decrease of days to first ovulation, a tendency to decrease service per conception rate, improved glandular morphology, a tendency to increase polymorphonuclear neutrophil infiltration, and a tendency to increase the tight-junction protein occludin. Supplementation of rumen-protected methionine during the transition period resulted in improved uterine immune function through improved glandular morphology, increased neutrophil infiltration number after calving, and discovery of neutrophil extracellular trap formation in bovine endometrial tissue. In conclusion, nutritional strategies during the transition impact uterine health and fertility in dairy cows.

scholarly journals The Physiological Roles of Vitamin E and Hypovitaminosis E in the Transition Period of High-Yielding Dairy Cows

Animals ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 1088
Author(s):  
Satoshi Haga ◽  
Hiroshi Ishizaki ◽  
Sanggun Roh
Keyword(s):  
Dairy Cows ◽  
High Performance ◽  
Molecular Mechanisms ◽  
Transition Period ◽  
Disease Risk ◽  
Serum Vitamin ◽  
Physiological Role ◽  
Density Lipoprotein ◽  
Alpha Tocopherol ◽  
Transition Dairy Cows

Levels of alpha-tocopherol (α-Toc) decline gradually in blood throughout prepartum, reaching lowest levels (hypovitaminosis E) around calving. Despite numerous reports about the disease risk in hypovitaminosis E and the effect of α-Toc supplementation on the health of transition dairy cows, its risk and supplemental effects are controversial. Here, we present some novel data about the disease risk of hypovitaminosis E and the effects of α-Toc supplementation in transition dairy cows. These data strongly demonstrate that hypovitaminosis E is a risk factor for the occurrence of peripartum disease. Furthermore, a study on the effectiveness of using serum vitamin levels as biomarkers to predict disease in dairy cows was reported, and a rapid field test for measuring vitamin levels was developed. By contrast, evidence for how hypovitaminosis E occurred during the transition period was scarce until the 2010s. Pioneering studies conducted with humans and rodents have identified and characterised some α-Toc-related proteins, molecular players involved in α-Toc regulation followed by a study in ruminants from the 2010s. Based on recent literature, the six physiological factors: (1) the decline in α-Toc intake from the close-up period; (2) changes in the digestive and absorptive functions of α-Toc; (3) the decline in plasma high-density lipoprotein as an α-Toc carrier; (4) increasing oxidative stress and consumption of α-Toc; (5) decreasing hepatic α-Toc transfer to circulation; and (6) increasing mammary α-Toc transfer from blood to colostrum, may be involved in α-Toc deficiency during the transition period. However, the mechanisms and pathways are poorly understood, and further studies are needed to understand the physiological role of α-Toc-related molecules in cattle. Understanding the molecular mechanisms underlying hypovitaminosis E will contribute to the prevention of peripartum disease and high performance in dairy cows.

Variations of energy-related biochemical metabolites during transition period in dairy cows

2007 ◽  
Vol 16 (4) ◽  
pp. 253-258 ◽  
Author(s):  
H. A. Seifi ◽  
M. Gorji-Dooz ◽  
M. Mohri ◽  
B. Dalir-Naghadeh ◽  
N. Farzaneh
Keyword(s):  
Dairy Cows ◽  
Transition Period
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