1054 Effect of exogenous β-hydroxybutyrate in the lateral ventricle on circulating serum metabolites and luteinizing hormone in castrated lambs

2016 ◽  
Vol 94 (suppl_5) ◽  
pp. 505-505
Author(s):  
E. R. Cope ◽  
B. H. Voy ◽  
B. K. Whitlock ◽  
J. D. Hobbs ◽  
Z. D. Mcfarlane ◽  
...  
Neurosurgery ◽  
1989 ◽  
Vol 25 (5) ◽  
pp. 820-823 ◽  
Author(s):  
Youichi Saitoh ◽  
Norio Arita ◽  
Toru Hayakawa ◽  
Kazutami Nakao ◽  
Heitaro Mogami

Abstract A 21-year-old man with an oligodendroglioma in the anterior horn of the right lateral ventricle complained of sexual dysfunction and showed lowered concentrations of serum testosterone (1.1 ng/ml) with normal pituitary function. Human chorionic gonadotropin testing revealed a good testosterone response (1.1 to 4.9 ng/ml) and a clomiphene test revealed no gonadotropin response. Pulsatile secretion of luteinizing hormone (LH) was absent preoperatively. After removal of the tumor, serum concentration of testosterone increased to the normal range, LH pulsatility appeared, and the patient had no complaints of sexual dysfunction. In this patient, the loss of LH pulsatility responsible for his hypogonadism was caused by the lateral ventricle tumor compressing the surrounding structures, and this was corrected by tumor resection.


1971 ◽  
Vol 50 (4) ◽  
pp. 679-683 ◽  
Author(s):  
R. COLLU ◽  
F. FRASCHINI ◽  
L. MARTINI

SUMMARY Melatonin and 5-methoxytryptophol, the two methoxyindoles of pineal origin, were injected into a lateral ventricle of the brain of immature female rats. Treatment was started on the 25th day of age and terminated when the vagina opened. The injection of both methoxyindoles resulted in a statistically significant delay in vaginal opening. Since previous experiments had shown that melatonin specifically inhibits secretion of luteinizing hormone and that 5-methoxytryptophol specifically blocks release of follicle-stimulating hormone, the present results support the hypothesis that the onset of sexual maturation needs a balanced secretion of both gonadotrophins.


1984 ◽  
Vol 106 (1) ◽  
pp. 30-37 ◽  
Author(s):  
Lise Wogensen ◽  
Jørgen Warberg

Abstract. Two μg of prostaglandin E2 (PGE2) was infused into a lateral ventricle of the brain of female rats at 09.00 or 13.00 h on the different days of the oestrous cycle and the effect on luteinizing hormone (LH) and prolactin (Prl) release was determined. At 09.00 h PGE2 caused a pronounced release of LH in pro-oestrous, oestrous and metoestrous rats whereas the LH response in dioestrous rats was moderate. The secretion of Prl was only stimulated in rats from the pro-oestrous phase. When infused at 13.00 h PGE2 had a marked stimulatory effect on the release of LH in all groups of rats. The response was almost the same in oestrous, metoestrous and dioestrous rats but pro-oestrous rats a 2-fold higher LH response was observed. On each day of the oestrous cycle it was found that the LH-releasing activity of PGE2 was greater at 13.00 h than at 09.00 h. Thus, the overall greatest responsiveness of LH to PGE2 was noted at 13.00 h on pro-oestrus i.e. at a time which was prior to the onset of the spontaneous LH surge. At 13.00 h – as at 09.00 h – PGE2 was only capable of stimulating Prl release in pro-oestrous rats. Resembling the LH response it was found that PGE2-induced Prl release was greater at 13.00 h than at 09.00 h. In adult male rats the stimulatory effect of PGE2 on LH and Prl release was independent of the time of administration. It is concluded that the neuroendocrine elements of the hypothalamo-pituitary unit in mature female rats exhibit cyclic as well as diurnal alterations in the responsiveness to PGE2.


1986 ◽  
Vol 112 (2) ◽  
pp. 180-184 ◽  
Author(s):  
Lise Wogensen ◽  
Jørgen Warberg

Abstract. One, 5 or 20 μg of prostaglandin D2 (PGD2) was infused into a lateral ventricle of the brain of anaesthetized intact or castrated male rats, and the response of luteinizing hormone (LH) and prolactin (Prl) was determined. PGD2 stimulated the release of LH in both groups of rats. The greatest LH-response was observed in the castrated rats, where the lowest dose of PGD2 (1 μg) caused the greatest LH response. This dose was ineffective in the non-castrated animals. PGD2 had no effect on the release of Prl neither in intact nor in orchidectomized rats. It is concluded that PGD2 is capable of stimulating the release of LH in male rats and that the stimulating effect is intensified by removal of the gonadal negative feedback effect on the hypothalamo-pituitary unit.


2001 ◽  
Vol 32 (1) ◽  
pp. 50-50
Author(s):  
S. F. Ge ◽  
M. N. Romanov ◽  
P. J. Sharp ◽  
D. W. Burt ◽  
I. R. Paton ◽  
...  

2000 ◽  
Vol 35 (3-4) ◽  
pp. 129-133
Author(s):  
B Gawronska ◽  
A Stepien ◽  
AJ Ziecik
Keyword(s):  

2004 ◽  
Vol 171 (4S) ◽  
pp. 368-369
Author(s):  
Sung Ho Lee ◽  
Soo Woong Kim ◽  
Jae-Seung Paick

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