0941 Comparing the effects of zinc oxide, milk hydrolysate, yeast β glucan, and combination of milk hydrolysate/yeast β glucan on growth, gut microbiota, and cytokine gene expression in weaning piglets

2016 ◽  
Vol 94 (suppl_5) ◽  
pp. 453-453
Author(s):  
A. Mukhopadhya ◽  
J. V. O'Doherty ◽  
N. Noronha ◽  
M. T. Ryan ◽  
T. Sweeney
Keyword(s):  
Gene Expression ◽  
Zinc Oxide ◽  
Gut Microbiota ◽  
Cytokine Gene Expression ◽  
Cytokine Gene ◽  
Weaning Piglets

scholarly journals Maternal supplementation of seaweed-derived polysaccharides improves intestinal health and immune status of suckling piglets

2015 ◽  
Vol 4 ◽  
Author(s):  
G. Heim ◽  
J. V. O'Doherty ◽  
C. J. O'Shea ◽  
D. N. Doyle ◽  
A. M. Egan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dietary Treatment ◽  
Intestinal Morphology ◽  
Cytokine Gene Expression ◽  
Cytokine Gene ◽  
Lps Challenge ◽  
Nutrient Transporter ◽  
Suckling Piglets ◽  
Small Intestinal ◽  
Weaning Piglets

AbstractThe experiment investigated the effect of maternal dietary supplementation of seaweed-derived polysaccharides (SDP) (–SDPv.+SDP,n   20) from day 83 of gestation until weaning (day 28) on selected sow faeces and piglet digesta microbiota populations, piglet small-intestinal morphology, and intestinal nutrient transporter and inflammatory cytokine gene expression at birth, 48 h after birth and weaning. The effect of maternal dietary treatment on the piglet gene expression profile of inflammatory cytokines in the colon following a lipopolysaccharide (LPS) challenge was also investigated. Dietary SDP reduced sow faecal Enterobacteriaceae gene numbers at parturition. Small-intestinal morphology, nutrient transporter and cytokine gene expression in newborn piglets did not differ between maternal dietary treatments (P > 0·10). At 48 h after birth, sodium–glucose-linked transporter 1 gene expression was down-regulated in the ileum of piglets suckling the SDP-supplemented sows compared with those suckling the basal sows (P = 0·050). There was a SDP × LPS challenge interaction onIL-1andIL-6gene expression in the colon of piglets (P < 0·05). The gene expression ofIL-1andIL-6was down-regulated in the LPS-challenged colon of piglets suckling the SDP sows compared with those suckling the basal sows (P < 0·05). However, there was no difference inIL-1andIL-6gene expression in the unchallenged colon between treatment groups. At weaning, piglets suckling the SDP-supplemented sows had increased villus height in the jejunum and ileum compared with those suckling the basal-fed sows (P < 0·05). In conclusion, maternal dietary SDP supplementation enhanced the immune response of suckling piglets and improved gut morphology, making them more immune competent to deal with post-weaning adversities.

scholarly journals Influenza A virus infection in turkeys induces respiratory and enteric bacterial dysbiosis correlating with cytokine gene expression

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e11806
Author(s):  
John M. Ngunjiri ◽  
Kara J.M. Taylor ◽  
Hana Ji ◽  
Michael C. Abundo ◽  
Amir Ghorbani ◽  
...  
Keyword(s):  
Gene Expression ◽  
Virus Infection ◽  
Gut Microbiota ◽  
Virus Replication ◽  
Influenza Viruses ◽  
Production Performance ◽  
Cytokine Gene Expression ◽  
Cytokine Gene ◽  
Expression Levels ◽  
Gene Expression Levels

Turkey respiratory and gut microbiota play important roles in promoting health and production performance. Loss of microbiota homeostasis due to pathogen infection can worsen the disease or predispose the bird to infection by other pathogens. While turkeys are highly susceptible to influenza viruses of different origins, the impact of influenza virus infection on turkey gut and respiratory microbiota has not been demonstrated. In this study, we investigated the relationships between low pathogenicity avian influenza (LPAI) virus replication, cytokine gene expression, and respiratory and gut microbiota disruption in specific-pathogen-free turkeys. Differential replication of two LPAI H5N2 viruses paralleled the levels of clinical signs and cytokine gene expression. During active virus shedding, there was significant increase of ileal and nasal bacterial contents, which inversely corresponded with bacterial species diversity. Spearman’s correlation tests between bacterial abundance and local viral titers revealed that LPAI virus-induced dysbiosis was strongest in the nasal cavity followed by trachea, and weakest in the gut. Significant correlations were also observed between cytokine gene expression levels and relative abundances of several bacteria in tracheas of infected turkeys. For example, interferon γ/λ and interleukin-6 gene expression levels were correlated positively with Staphylococcus and Pseudomonas abundances, and negatively with Lactobacillus abundance. Overall, our data suggest a potential relationship where bacterial community diversity and enrichment or depletion of several bacterial genera in the gut and respiratory tract are dependent on the level of LPAI virus replication. Further work is needed to establish whether respiratory and enteric dysbiosis in LPAI virus-infected turkeys is a result of host immunological responses or other causes such as changes in nutritional uptake.

scholarly journals Cytokine gene expression in skin of susceptible guinea‐pig infected withTreponema pallidum

Immunology ◽  
1998 ◽  
Vol 95 (2) ◽  
pp. 242-247 ◽  
Author(s):  
WICHER ◽  
SCAROZZA ◽  
RAMSINGH ◽  
WICHER
Keyword(s):  
Gene Expression ◽  
Guinea Pig ◽  
Cytokine Gene Expression ◽  
Cytokine Gene

scholarly journals Epigenetic Regulation of Cytokine Gene Expression in T Lymphocytes

2009 ◽  
Vol 50 (3) ◽  
pp. 322 ◽  
Author(s):  
Choong-Gu Lee ◽  
Anupama Sahoo ◽  
Sin-Hyeog Im
Keyword(s):  
Gene Expression ◽  
T Lymphocytes ◽  
Epigenetic Regulation ◽  
Cytokine Gene Expression ◽  
Cytokine Gene
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