Effect of hypothyroidism on the blood lipid response to higher dietary fat intake in mares12

2004 ◽  
Vol 82 (9) ◽  
pp. 2640-2646 ◽  
Author(s):  
N. Frank ◽  
J. E. Sojka ◽  
M. A. Latour
Keyword(s):  
Dietary Fat ◽  
Blood Lipid ◽  
Fat Intake ◽  
Dietary Fat Intake ◽  
Lipid Response

scholarly journals Genetic Variants in Lipid Metabolism Pathways Interact with Diet to Influence Blood Lipid Concentrations in Adults with Overweight and Obesity

2020 ◽  
Vol 13 (6) ◽  
pp. 155-163
Author(s):  
Bridget A. Hannon ◽  
Caitlyn G. Edwards ◽  
Sharon V. Thompson ◽  
Sarah K. Burke ◽  
Nicholas A. Burd ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Dietary Intake ◽  
Dietary Fat ◽  
Genetic Variants ◽  
Blood Lipid ◽  
Overweight And Obesity ◽  
Cardiometabolic Health ◽  
Fat Intake ◽  
Dietary Fat Intake ◽  
Increased Risk

<b><i>Introduction:</i></b> The effect of various types of dietary fat on cardiometabolic health continues to be debated, due in part to the high heterogeneity of results following clinical trials investigating the effects of saturated (SFA) and unsaturated fat intake. This variability may be due to genetic differences. Individuals with obesity are at an increased risk for adverse cardiometabolic health and dyslipidemia, and often present with the combined phenotype of elevated triglyceride (TG) and decreased high-density lipoprotein (HDL) cholesterol concentrations. Studying genetic variants relevant to lipid and lipoprotein metabolism can elucidate the mechanisms by which diet might interact with genotype to influence these phenotypes. The objective of this study was to determine relationships of genetic variation, dietary fat intake, and blood lipid concentrations in adults with overweight and obesity. <b><i>Methods:</i></b> Genomic DNA, blood lipid concentrations (HDL and TG), and 7-day diet records were obtained from 101 adults (25–45 years of age) with overweight or obesity. Resting energy expenditure (REE) was measured using indirect calorimetry and used to determine implausible intakes using a modified Goldberg method (kilocalories/REE). Genetic variants included 23 single-nucleotide polymorphisms (SNPs) from 15 genes in lipid metabolism pathways. Variants were analyzed with dietary fat intake (total fat, SFA, monounsaturated fat [MUFA], and polyunsaturated fat [PUFA]) via regression analyses. All models were adjusted for age, sex, ancestry, visceral adipose tissue mass, and total kilocalorie intake. The Bonferroni correction was applied for multiple comparisons. <b><i>Results:</i></b> Two interactions were detected for TG concentrations. Five gene-diet interactions were associated with HDL concentrations. There was a significant interaction detected between the rs5882 variant of cholesterol-esterase transfer protein (<i>CETP</i>) and MUFA intake to associate with TG concentrations (interaction <i>p</i> = 0.004, <i>R</i><sup>2</sup> = 0.306). Among carriers of the <i>CETP-</i>rs5882 major allele (G), TG concentrations were significantly lower in individuals consuming more than the median MUFA intake (31 g/day) than in those with an intake below the median. Total dietary fat intake interacted with the rs13702 polymorphism of lipoprotein lipase (<i>LPL</i>) to associate with HDL concentrations (interaction <i>p</i> = 0.041, <i>R</i><sup>2</sup> = 0.419), by which individuals with the risk allele (G) had significantly higher HDL concentrations when consuming a higher-fat diet (&#x3e;92 g/day) than those with a lower-fat diet (56 ± 3 vs. 46 ± 2 mg/dL, <i>p</i> = 0.033). <b><i>Conclusions:</i></b> Interactions between dietary intake and genes in lipid metabolism pathways were found to be associated with blood lipid concentrations in adults with overweight and obesity. Fatty acid intake may not modulate blood lipid concentrations uniformly across all individuals. Additional research is needed to determine the biological causes of individual variability in response to dietary intake. Understanding the influence of nutrigenetic interactions on dyslipidemia can aid in the development and implementation of personalized dietary strategies to improve health.

Do Parent Anhedonia and Stress Contribute to Weight-related Parenting Practices, Child Dietary Fat Intake and Child BMI Percentile?

2013 ◽  
Author(s):  
Eleanor B. Tate ◽  
Susan M. Schembre ◽  
Gillian O'Reilly ◽  
Mary Ann Pentz ◽  
Genevieve Dunton
Keyword(s):  
Dietary Fat ◽  
Parenting Practices ◽  
Fat Intake ◽  
Dietary Fat Intake ◽  
Child Bmi

Comparison of Dietary Fat Intake Using Food Records vs. RBC Fatty Acid Biomarkers in a Multiethnic Population—The Federal Women Study

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1893-P
Author(s):  
AMBER B. COURVILLE ◽  
SHANNA BERNSTEIN ◽  
MIRELLA GALVAN-DE LA CRUZ ◽  
ANTHONY ONUZURUIKE ◽  
NIRUPA R. MATTHAN ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Dietary Fat ◽  
Fat Intake ◽  
Food Records ◽  
Dietary Fat Intake ◽  
Multiethnic Population ◽  
Fatty Acid Biomarkers

1734-P: High Dietary Fat Intake Exacerbates Insulin Resistance in a Type 2 Diabetes Genetic Mouse Model

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1734-P
Author(s):  
AUSTIN REILLY ◽  
SHIJUN YAN ◽  
ALEXA J. LONCHARICH ◽  
HONGXIA REN
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Mouse Model ◽  
Dietary Fat ◽  
Fat Intake ◽  
Dietary Fat Intake ◽  
Genetic Mouse Model

Dietary Fat Intake and Risk of Alzheimer’s Disease and Dementia: A Meta-Analysis of Cohort Studies

2018 ◽  
Vol 15 (9) ◽  
pp. 869-876 ◽  
Author(s):  
Yue Ruan ◽  
Jun Tang ◽  
Xiaofei Guo ◽  
Kelei Li ◽  
Duo Li
Keyword(s):  
Cohort Studies ◽  
Dietary Fat ◽  
Prospective Cohort ◽  
Meta Analysis ◽  
Saturated Fat ◽  
Fat Intake ◽  
Prospective Cohort Studies ◽  
Dietary Fat Intake ◽  
Dementia Risk ◽  
Saturated Fat Intake

Background: Epidemiological studies showed that dietary fat intake is associated with Alzheimer’s disease (AD) and dementia risk, however, the association remain inconsistent. This metaanalysis aimed to systematically examine the association of dietary fat intake with AD and dementia risk. Methods: We have systematically searched PubMed, Embase and the Cochrane Library up to May 1st 2017. Prospective cohort studies were included if they reported on the association of dietary fat intake with AD and dementia risk. Multivariate-adjusted relative risks (RRs) for the highest versus lowest category were pooled by using a random-effects model. Results: A total of 8630 participants and 633 cases from four independent prospective cohort studies were included in the present meta-analysis. A higher dietary saturated fat intake was significantly associated with an increased risk of 39% and 105% for AD (RR: 1.39; 95% CI: 1.00, 1.94) and dementia (RR: 2.05; 95% CI: 1.06, 3.98), respectively. Dose-response analysis indicated a 4 g/day increment of saturated fat intake was related to 15% higher risk of AD (RR: 1.15; 95% CI: 1.01, 1.31). However, there was no significant association found between dietary intake of total, monounsaturated, polyunsaturated fat and AD or dementia risk. Conclusions: This meta-analysis provides significant evidence of positive association between higher saturated fat intake and AD and dementia risk.

scholarly journals Dietary fat intake and liver cancer incidence: A population‐based cohort study in Chinese men

2021 ◽  
Vol 148 (12) ◽  
pp. 2982-2996
Author(s):  
Xiao‐Wei Ji ◽  
Jing Wang ◽  
Qiu‐Ming Shen ◽  
Zhuo‐Ying Li ◽  
Yu‐Fei Jiang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Liver Cancer ◽  
Cancer Incidence ◽  
Dietary Fat ◽  
Population Based ◽  
Fat Intake ◽  
Chinese Men ◽  
Dietary Fat Intake
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