scholarly journals Influence of lipopolysaccharide-induced immune challenge and diet complexity on growth performance and acute-phase protein production in segregated early-weaned pigs.

1996 ◽  
Vol 74 (7) ◽  
pp. 1620 ◽  
Author(s):  
S S Dritz ◽  
K Q Owen ◽  
R D Goodband ◽  
J L Nelssen ◽  
M D Tokach ◽  
...  
Keyword(s):  
Growth Performance ◽  
Acute Phase ◽  
Protein Production ◽  
Acute Phase Protein ◽  
Immune Challenge ◽  
Weaned Pigs ◽  
Phase Protein

scholarly journals Ibuprofen reduces energy expenditure and acute-phase protein production compared with placebo in pancreatic cancer patients

1995 ◽  
Vol 72 (1) ◽  
pp. 185-188 ◽  
Author(s):  
SJ Wigmore ◽  
JS Falconer ◽  
CE Plester ◽  
JA Ross ◽  
JP Maingay ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Energy Expenditure ◽  
Cancer Patients ◽  
Acute Phase ◽  
Protein Production ◽  
Acute Phase Protein ◽  
Phase Protein

scholarly journals Interleukin-8 can mediate acute-phase protein production by isolated human hepatocytes

1997 ◽  
Vol 273 (4) ◽  
pp. E720-E726 ◽  
Author(s):  
Stephen J. Wigmore ◽  
Kenneth C. H. Fearon ◽  
Jean P. Maingay ◽  
Paul B. S. Lai ◽  
James A. Ross
Keyword(s):  
Pancreatic Cancer ◽  
Cell Line ◽  
Acute Phase ◽  
Protein Production ◽  
Acute Phase Protein ◽  
Human Hepatocytes ◽  
Human Pancreatic Cancer ◽  
Pancreatic Cancer Cells ◽  
Phase Protein

During the course of studies designed to identify the role of cytokines in the reprioritization of hepatic protein synthesis associated with cachexia we detected a hepatocyte-stimulating moiety in the supernatants of pancreatic cancer cells that was unrelated to interleukin (IL)-6. This study identifies that moiety as IL-8 and investigates the role of IL-8 in the induction of acute-phase protein production. The human pancreatic cancer cell line MIA PaCa-2 produced >1 ng/ml of IL-8 per 24 h, and supernatants from this cell line induced C-reactive protein (CRP) production from isolated human hepatocytes. Addition of neutralizing anti-human IL-8 antibody to such supernatants produced almost complete inhibition of CRP production. The addition of recombinant human IL-8 to hepatocytes resulted in a dose-dependent increase in CRP, α1-acid glycoprotein, and α1-antichymotrypsin production and a decrease in the production of transferrin and prealbumin. This study demonstrates that recombinant or tumor-derived IL-8 can modulate acute-phase protein production from isolated human hepatocytes and from human hepatoma cells.

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