scholarly journals Paraneoplastic pemphigus associated with Castleman’s disease in a 13-year-old boy

2020 ◽  
Vol 0 ◽  
pp. 1-4
Author(s):  
Neema Joy ◽  
Anuja Elizabeth George ◽  
Lissy Skaria
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Clinical Remission ◽  
Castleman’S Disease ◽  
Skin Lesions ◽  
Treatment Evaluation ◽  
Castleman's Disease ◽  
Paraneoplastic Pemphigus ◽  
Autoimmune Blistering Disease ◽  
Underlying Malignancy ◽  
Blistering Disease

Paraneoplastic pemphigus is an autoimmune blistering disease associated with an underlying malignancy. This is a case of a 13-year-old boy initially presenting with isolated oral erosions – managed as a case of pemphigus, who one and a half years later developed toxic epidermal necrolysis like rash, both refractory to treatment. Evaluation for an underlying malignancy revealed a retroperitoneal Castleman’s tumor, following the excision of which there was clinical remission of the oral and skin lesions.

scholarly journals Anaesthetic management of Castleman’s disease associated with paraneoplastic pemphigus: report of a rare case

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Rajasree O. ◽  
Divya V. Gladston ◽  
Arya Jayadevan ◽  
Rachel Cherian Koshy
Keyword(s):  
Castleman’S Disease ◽  
Skin Lesions ◽  
Anaesthetic Management ◽  
Lymphoproliferative Disease ◽  
Age Group ◽  
Castleman's Disease ◽  
Malignant Tumours ◽  
Care Needs ◽  
Paraneoplastic Pemphigus ◽  
Paediatric Age

Abstract Background Castleman’s disease is a rare lymphoproliferative disease which can mimic other malignant tumours and can be associated with paraneoplastic pemphigus especially in the paediatric age group. This presentation can be challenging even to the seasoned anaesthesiologist when it comes to managing such a case presenting for laparotomy. Case presentation Here such a case in a 12-year-old who was initially diagnosed as retroperitoneal sarcoma complicated with paraneoplastic pemphigus and inferior venacaval thrombus is presented and its anaesthetic management and challenges are discussed. Special care needs to be taken while anaesthetizing such a patient keeping in mind the difficult airway, adrenocortical suppression, and exacerbation of skin lesions due to various anaesthetic procedures. For this case, the histopathology turned out to be Castleman’s disease. Conclusion The anaesthetic challenges associated with paraneoplastic pemphigus in paediatric age group receiving perioperative thromboprophylaxis need special mention. Here we are discussing the challenges and anaesthetic management of such a case as literature on this aspect is few.

Castleman's disease associated pemphigus. A form of paraneoplastic pemphigus

1995 ◽  
Vol 4 (3) ◽  
pp. 273-279 ◽  
Author(s):  
Daniel A. Vardy ◽  
Laurent Klapholz ◽  
Chaim Brautbar ◽  
Anat R. Tambur ◽  
Sara Pisanty ◽  
...  
Keyword(s):  
Castleman’S Disease ◽  
Castleman's Disease ◽  
Paraneoplastic Pemphigus

scholarly journals A case of paraneoplastic pemphigus associated with Castleman's disease in the retroperitoneal region

2008 ◽  
Vol 54 (6) ◽  
pp. 381-385
Author(s):  
Kenichiro UCHIDA ◽  
Takamitsu MANO ◽  
Daiju HORINAGA ◽  
Yuzo MIZUGAKI ◽  
Takashi HASHIMOTO ◽  
...  
Keyword(s):  
Castleman’S Disease ◽  
Castleman's Disease ◽  
Paraneoplastic Pemphigus

Paraneoplastic Pemphigus and Castleman’s Disease in the Setting of Herpes Simplex Virus Infection

2011 ◽  
Vol 29 (5) ◽  
pp. 629-632 ◽  
Author(s):  
Laine H. Koch ◽  
Christle J. Layton ◽  
Monika Pilichowska ◽  
Miguel J. Stadecker ◽  
Orr Barak
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Infection ◽  
Herpes Simplex Virus Infection ◽  
Castleman’S Disease ◽  
Castleman's Disease ◽  
Paraneoplastic Pemphigus ◽  
Simplex Virus

Paraneoplastic Pemphigus Associated with Castleman's Disease: Usefulness of the Laboratory of Autoimmunity in the Diagnosis of This Disease

2007 ◽  
Vol 1107 (1) ◽  
pp. 231-238 ◽  
Author(s):  
I. ALARCON-TORRES ◽  
J. BASTIDA-INARREA ◽  
M.J. RODRIGUEZ-SALIDO ◽  
J. GOMEZ-DUASO ◽  
I. RUA-FIGUEROA ◽  
...  
Keyword(s):  
Castleman’S Disease ◽  
Castleman's Disease ◽  
Paraneoplastic Pemphigus

scholarly journals A Clinical Profile and Co-morbidities of Pemphigus Vulgaris Patients: A Study of 35 Cases

KYAMC Journal ◽  
2019 ◽  
Vol 10 (2) ◽  
pp. 106-109
Author(s):  
Md Abdur Razzaque ◽  
Zulfikar Ali ◽  
Kazi Shihab Uddin ◽  
Md Imtiajul Islam ◽  
Sajib Kumar Nath
Keyword(s):  
Pemphigus Vulgaris ◽  
Skin Lesions ◽  
Cutaneous Lesions ◽  
Female Ratio ◽  
Medical College ◽  
Autoimmune Blistering Disease ◽  
Blistering Disease ◽  
High Index Of Suspicion ◽  
Male To Female ◽  
Sixth Decade

Background: Pemphigus vulgaris (PV), an autoimmune blistering disease involving the skin and mucosa. PV frequently begins with oral lesions and progresses to skin lesions. Autoimmune bullous skin disorders are associated with IgG or IgA auto- antibodies against distinct adhesion molecules of the epidermis and dermal epidermal basement membrane zone, respectively. These auto- antibodies lead to a loss of skin adhesion which shows up clinically as the formation of blisters or erosions. Objectives: To characterize the clinical parameters and co-morbidities of PV patients from a single tertiary medical centre in Bangladesh. Material and Methods: This observational study was done including 35 PV patients attending in the department of Dermatology and Venereology, Khwaja Yunus Ali Medical College Khawja Eunus Ali Medical College from 2010 to 2014. Thirty patients of pemphigus diagnosed clinically confirmed and treated over a 4-year period (2010-2014). Results: Majority of the patients 45.7% belongs to age group 41-50 years. Mean age 47.12±11.13. The male to female ratio in our study sample was 1:1.5. The youngest patient was 17 years old and the oldest 68. For both genders, the risk of onset peaked during the fifth and sixth decade of life. Out of 35 patients, 15(42.9%) was presented with mucosal lesions only, while 13 patients 37.1% had mucocutaneous lesions and 7 patients 20% had only cutaneous lesions. The most common comorbidies were hypertension 20.0%, osteoporosis 17.1%, and diabetes 8.6%, thyroid disease 8.6%, psoriasis 5.7%, rheumatoid arthritis 2.7%, rheumatic fever 2.9%, autoimmune hepatitis 2.9%, and myasthenia gravis 2.9%. Conclusion: The associated comorbidities of PV emphasize the need for dermatologists to keep a high index of suspicion and actively evaluate patients to determine their presence. KYAMC Journal Vol. 10, No.-2, July 2019, Page 106-109

scholarly journals Paraneoplastic Pemphigus Caused by Castleman’s Disease Masquerading as an Adrenal Neoplasm

2009 ◽  
Vol 94 (6) ◽  
pp. 1841-1842 ◽  
Author(s):  
Bing-bing Shi ◽  
Han-zhong Li ◽  
Lei Zhao ◽  
Qiuning Sun ◽  
Hua Fan ◽  
...  
Keyword(s):  
Castleman’S Disease ◽  
Castleman's Disease ◽  
Adrenal Neoplasm ◽  
Paraneoplastic Pemphigus

scholarly journals Pemphigus Vulgaris Presented with Cheilitis

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Zaheer Abbas ◽  
Zahra Safaie Naraghi ◽  
Elham Behrangi
Keyword(s):  
Pemphigus Vulgaris ◽  
Skin Lesions ◽  
Lower Lip ◽  
Additional Lesion ◽  
Autoimmune Blistering Disease ◽  
Systemic Corticosteroids ◽  
Erosive Lichen Planus ◽  
Blistering Disease ◽  
One Year

Background. Pemphigus vulgaris is an autoimmune blistering disease affecting the mucous membrane and skin. In 50 to 70% of cases, the initial manifestations of pemphigus vulgaris are oral lesions which may be followed by skin lesions. But it is unusual for the disease to present with initial and solitary persistent lower lip lesions without progression to any other location.Main Observations. We report a 41-year-old woman with dry crusted lesions only on the lower lip, clinically resembling actinic cheilitis and erosive lichen planus, but histopathological evaluation showed unexpected results of suprabasal acantholysis and cleft compatible with pemphigus vulgaris. We treated her with intralesional triamcinolone 10 mg/mL for 2 sessions and 2 g cellcept daily. Patient showed excellent response and lesions resolved completely within 2 months. In one-year follow-up, there was no evidence of relapse or any additional lesion on the other sites.Conclusion. Cheilitis may be the initial and sole manifestation of pemphigus vulgaris. Localized and solitary lesions of pemphigus vulgaris can be treated and controlled without systemic corticosteroids.

Paraneoplastic pemphigus with Castleman's disease and bronchiolitis obliterans

2011 ◽  
Vol 53 (6) ◽  
pp. 1108-1109 ◽  
Author(s):  
Tarun Jindal ◽  
Monika Meena ◽  
Arvind Kumar ◽  
Binod K. Khaitan
Keyword(s):  
Bronchiolitis Obliterans ◽  
Castleman’S Disease ◽  
Castleman's Disease ◽  
Paraneoplastic Pemphigus

scholarly journals Overlap of IgG4-related Disease and Multicentric Castleman's Disease in a Patient with Skin Lesions

2017 ◽  
Vol 56 (9) ◽  
pp. 1095-1099 ◽  
Author(s):  
Hiroki Mochizuki ◽  
Manako Kato ◽  
Takakazu Higuchi ◽  
Ryosuke Koyamada ◽  
Satoru Arai ◽  
...  
Keyword(s):  
Castleman’S Disease ◽  
Skin Lesions ◽  
Castleman's Disease ◽  
Multicentric Castleman’S Disease ◽  
Related Disease ◽  
Igg4 Related Disease ◽  
Multicentric Castleman's Disease
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