scholarly journals Studying the evolution of miasm in autism spectrum disorders: A case series

2020 ◽  
Vol 3 ◽  
pp. 43-50 ◽  
Author(s):  
Sunita Bhanudas Nikumbh
Keyword(s):  
Developmental Disorders ◽  
Developmental Disorder ◽  
Neurodevelopmental Disorder ◽  
Case Series ◽  
Autism Spectrum ◽  
Children With Asd ◽  
Current Prevalence ◽  
Icd 10 ◽  
History Of ◽  
Spectrum Disorders

Objectives: Autism spectrum disorder (ASD), a neurodevelopmental disorder, is one of the several developmental disorders observed in children. The current prevalence of ASD among those under 18 years of age is 0.09 and 0.11 in an urban and rural area, respectively. Being a developmental disorder, it starts showing signs in the first 3 years of life and is present for the rest of the individual’s life. Studies have identified genetic predominance and a disturbed mental state in the mother during pregnancy in the genesis of disease. Modern medicinal interventions target only some specific and uncontrolled behaviours in ASD children; hence, the management is focused mainly on self-sustenance with integrated care with the help of ancillary therapies. Homoeopathically, these factors carry considerable importance as they contribute to the fundamental or miasmatic load, based on which the totality is formulated to select homeopathic simillimum. This paper studies the miasm in ASD cases treated in the Child Psychiatry OPD at Dr. M. L. Dhawale Memorial Homoeopathic Institute, Palghar (2015–2018) by studying miasmatic load in detail. Materials and Methods: ASD cases diagnosed according to ICD-10 criteria were studied in detail with evolutionary data collected from parents in terms of current complaints and illnesses (past, personal and family) in both families and were analysed for miasmatic load. The fundamental and dominant miasm derived from the disease expressions and history of family illnesses. Homoeopathic simillimum selected based on the predominant miasm/s along with the totality erected as per the available characteristic expressions in the cases. Results: Administration of simillimum healed the patient at the constitutional and miasmatic level and resulted insignificant improvement in the characteristic expressions in the patients. Timely identification and intervention yield a quicker response. Conclusion: Selecting homoeopathic remedies that cover the miasmatic background yields good results in children with ASD.

scholarly journals LA ACTUACION SANITARIA EN ATENCIÓN TEMPRANA PARA PERSONAS CON TRASTORNO DE ESPECTRO AUTISTA (TEA): UNA EXPERIENCIA EN ANDALUCÍA

2017 ◽  
Vol 7 (1) ◽  
pp. 463
Author(s):  
Mª Araceli Sánchez Raya
Keyword(s):  
Health Care ◽  
Autism Spectrum Disorders ◽  
Early Intervention ◽  
Early Detection ◽  
Functional Recovery ◽  
Developmental Disorders ◽  
Autism Spectrum ◽  
Theoretical Interest ◽  
Children With Asd ◽  
Spectrum Disorders

Abstract.It is undeniable the importance of early detection in all developmental disorders, in children with ASD as well, for an early intervention in children and their families. An early intervention is a very important predictor in their functional recovery. That, put together with the growing incidence and prevalence of this kind of disorders, makes of our study field a matter of an increasing scientific and theoretical interest. In the current paper we deal with earlydetection, evaluation and intervention in children between 0 and 6 years with autism spectrum disorders in andalusian health care system.Resumen.Es innegable la importancia que tiene la detección precoz de cualquier trastorno del desarrollo –y por ende del TEA- para la intervención temprana con los menores y sus familias. Una intervención temprana constituye un importante predictor en la recuperación funcional de estos menores, y esto unido a la creciente incidencia y prevalencia de estos trastornos, hace de nuestro objeto de estudio un tema creciente de gran interés científico y teórico. En la presente comunicación abordamos el circuito de detección, evaluación e intervención temprana en niñas y niños de 0 a 6 años con trastorno del espectro autista en la sanidad andaluza.

Millennium Nutrient N,N-Dimethylglycine (DMG) and its Effectiveness in Autism Spectrum Disorders.

2021 ◽  
Vol 28 ◽  
Author(s):  
Daljeet Singh Dhanjal ◽  
Sonali Bhardwaj ◽  
Chirag Chopra ◽  
Reena Singh ◽  
Jiri Patocka ◽  
...  
Keyword(s):  
Conventional Medicine ◽  
Neurodevelopmental Disorder ◽  
Treatment Options ◽  
Autism Spectrum ◽  
Autistic Children ◽  
Children With Asd ◽  
Drastic Increase ◽  
Spectrum Disorders ◽  
Approved Drugs ◽  
Core Symptoms

: Autism is a neurodevelopmental disorder belonging to the autism spectrum disorder (ASD). In ASDs, the individuals show substantial impairments in social communication, repetitive behaviours, and sensory behaviours deficits in the early stages of their life. Globally, the prevalence of autism is estimated to be less than 1%, especially in high-income countries. In recent decades, there has been a drastic increase in the incidence of ASD, which has put ASD into the category of epidemics. Presently, two US Food and Drug Administration-approved drugs, aripiprazole and risperidone are used to treat symptoms of agitation and irritability in autistic children. However, to date, no medication has been found to treat the core symptoms of ASD. The adverse side effects of conventional medicine and limited treatment options have led families and parents of autistic children to turn to complementary and alternative medicine (CAM) treatments, which are perceived as relatively safe compared to conventional medicine. Recently, N,N-dimethylglycine (DMG), a dietary supplement, has emerged as a useful supplement to improve the mental and physical state of children with ASD. The current review discusses ASD, the prevalence of ASD, CAM approach and efficacy of CAM treatment in children with ASD. Moreover, it highlights the chemistry, pharmacological effect, and clinical studies of DMG, highlighting its potential for improving the lifestyle of children with ASD.

scholarly journals The Application of AI as Reinforcement in the Intervention for Children With Autism Spectrum Disorders (ASD)

2019 ◽  
Vol 9 (2) ◽  
pp. 17
Author(s):  
Jing SHI
Keyword(s):  
Autism Spectrum Disorders ◽  
Applied Behavior Analysis ◽  
Developmental Disorder ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Future Application ◽  
Behavioral Deficits ◽  
Children With Asd ◽  
Spectrum Disorders

Autism Spectrum Disorders (ASD) is a neuro-developmental disorder. There is a tremendous variability in individuals with ASD; however, it is mainly characterized by social behavioral deficits. Across the globe, the prevalence of ASD is fairly consistent and the most current estimates are 1 in 59. There is no biological cure for people with ASD and intervention is widely accepted as the only solution for them to improve the quality of their lives. Among all the treatments, Applied Behavior Analysis (ABA) has more quantity of evidence than other methods and it has more studies with the strongest levels of evidence. Using reinforcement is a vital and indispensable part of ABA. Many researches reveal that children with ASD are more likely to become interested in robots or other forms of Artificial Intelligence (AI) and in fact AI is used in the intervention for children with ASD. The application of AI has been proven to be feasible and effective in the interventions. This essay aims at analyzing the effects of the application of AI as reinforcement in ABA and providing suggestions for application of AI in other aspects of ABA intervention. Hopefully this essay will be suggestive for the future application of AI in terms of assisting the intervention for children with ASD in order to reduce the workload and cost.

scholarly journals Glutathione S-Transferase Polymorphisms and Clinical Characteristics in Autism Spectrum Disorders

2021 ◽  
Vol 12 ◽  
Author(s):  
Vanja Mandic-Maravic ◽  
Marija Mitkovic-Voncina ◽  
Marija Pljesa-Ercegovac ◽  
Ana Savic-Radojevic ◽  
Miroslav Djordjevic ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Clinical Characteristics ◽  
Developmental Disorders ◽  
Adaptive Functioning ◽  
Autism Spectrum ◽  
Diagnostic Interview ◽  
Environment Interaction ◽  
Gst Polymorphisms ◽  
Children With Asd ◽  
Spectrum Disorders

Background: Autism spectrum disorders (ASD) are a heterogeneous group of developmental disorders, with different levels of symptoms, functioning, and comorbidities. Recent findings suggested that oxidative stress and genetic variability in glutathione S-transferases (GSTs) might increase the risk of ASD development. We aimed to determine whether GST polymorphisms influence the severity of symptoms as well as the cognitive and adaptive abilities in children with ASD.Methods: The sample included 113 ASD cases. All participants were genotyped for GSTA1, GSTM1, GSTT1, and GSTP1 polymorphisms. The clinical characteristics were determined with Autism Diagnostic Interview-Revised (ADI-R) in all of the participants. In non-verbal participants, we explored the adaptive functioning using the Vineland Adaptive Behavior Scale II, while in verbal participants, we used the Wechsler Abbreviated Scale of Intelligence (WASI).Results: It was shown that the GSTA1*CC genotype was a predictor of a lower non-verbal communication impairment as well as of a lower chance of having seizures during life. GSTM1-active genotype predicted a higher adaptive functioning. The predictive effect of GSTA1, GSTM1, and GSTT1 genotype was moderated by exposure during pregnancy (maternal smoking and medication). The GSTP1*IleIle genotype was significantly associated to a better cognitive functioning in children with ASD.Conclusion: Besides the complex gene-environment interaction for the specific risk of developing ASD, there is also a possible complexity of interactions between genetic and environmental factors influencing the level of symptoms and impairment in people with ASD. Detoxification and antioxidant enzymes, such as GSTA1, might contribute to the core of this complexity.

scholarly journals Schizophrenia, autism spectrum disorders and developmental disorders share specific disruptive coding mutations

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Elliott Rees ◽  
Hugo D. J. Creeth ◽  
Hai-Gwo Hwu ◽  
Wei J. Chen ◽  
Ming Tsuang ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Neurodevelopmental Disorders ◽  
Developmental Disorders ◽  
De Novo ◽  
Neurodevelopmental Disorder ◽  
Autism Spectrum ◽  
Increase Risk ◽  
Spectrum Disorders ◽  
Using Data ◽  
Shared Risk

AbstractPeople with schizophrenia are enriched for rare coding variants in genes associated with neurodevelopmental disorders, particularly autism spectrum disorders and intellectual disability. However, it is unclear if the same changes to gene function that increase risk to neurodevelopmental disorders also do so for schizophrenia. Using data from 3444 schizophrenia trios and 37,488 neurodevelopmental disorder trios, we show that within shared risk genes, de novo variants in schizophrenia and neurodevelopmental disorders are generally of the same functional category, and that specific de novo variants observed in neurodevelopmental disorders are enriched in schizophrenia (P = 5.0 × 10−6). The latter includes variants known to be pathogenic for syndromic disorders, suggesting that schizophrenia be included as a characteristic of those syndromes. Our findings imply that, in part, neurodevelopmental disorders and schizophrenia have shared molecular aetiology, and therefore likely overlapping pathophysiology, and support the hypothesis that at least some forms of schizophrenia lie on a continuum of neurodevelopmental disorders.

scholarly journals Perception of Special Teachers on the Evidence based Intervention Strategies for Children with Autism Spectrum Disorder

2019 ◽  
Vol 8 (3S2) ◽  
pp. 427-434
Keyword(s):  
Autism Spectrum Disorder ◽  
Developmental Disorders ◽  
Neurodevelopmental Disorder ◽  
Autism Spectrum ◽  
Intervention Strategies ◽  
Spectrum Disorder ◽  
Evidence Based ◽  
Graduate Degree ◽  
Chi Square ◽  
Children With Asd

Autism Spectrum Disorder (ASD) is one of five developmental disorders, it is a complex neurodevelopmental disorder affecting the ability of the person to socialize, communicate along with stereotype behaviours. ASD can affect any person irrespective of the gender, caste, creed or religion. Intervention means doing something, taking action or using a treatment to try to improve a particular condition or a problem. When it comes to ASD, there are many kinds of interventions offered. Depending on the type, they can involve the child, the parent or both. They might be one-off events or involve many sessions spread over years. Interventions are based on different theories about what causes ASD. The current study which is a part of the PhD tries to study the perception of special teachers on the current Intervention strategies for children with ASD. The study was conducted by circulating the questionnaire developed to the special teachers (n=40) working for ASD in the country. The participants consisted of special teachers having Diploma, Degree) and Post Graduate degree in the field of ASD (n=40). Descriptive statistics; frequency, percentages, and chi square tests were done using SPSS. The results indicated that teachers accepted the need for evidence based intervention strategies for training children with ASD.

Aided Augmentative and Alternative Communication (AAC) Systems for Individuals With Autism Spectrum Disorders

2020 ◽  
pp. 87-106
Author(s):  
Yashomathi
Keyword(s):  
Autism Spectrum Disorders ◽  
Augmentative And Alternative Communication ◽  
Developmental Disorders ◽  
Autism Spectrum ◽  
Repetitive Behaviors ◽  
Functional Communication ◽  
Alternative Communication ◽  
Children With Asd ◽  
Spectrum Disorders ◽  
Communication Needs

Autism spectrum disorders (ASDs) are complex neuro-developmental disorders. They demonstrate pervasive deficits in social communication, restricted and repetitive behaviors, cognitive impairments, etc. Most often individuals with ASDs are often considered “non-verbal” and they require comprehensive intervention to improve their functional communication skills. Augmentative and alternative communication (AAC) was always viewed as a “last resort” for people with complex communication needs when all other interventions failed to achieve the potential benefit. However, with growing evidence, AAC has been implemented even in children with communication difficulties to augment spoken language development. Thus, this chapter aims to discuss the characteristics of ASD, to describe the need for AAC intervention in children with ASD, challenges and practices of AAC in ASD, to review implementation of aided AAC systems for children with ASD in different contexts, to indicate the gaps and future prospective in AAC intervention for people with ASDs.

scholarly journals Mood Disorders in Mothers of Children on the Autism Spectrum Are Associated with Higher Functioning Autism

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Roma A. Vasa ◽  
Connie Anderson ◽  
Alison R. Marvin ◽  
Rebecca E. Rosenberg ◽  
J. Kiely Law ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Mood Disorder ◽  
Mood Disorders ◽  
Autism Spectrum ◽  
Logistic Regression Models ◽  
Maternal Mood ◽  
Asperger Disorder ◽  
Children With Asd ◽  
History Of ◽  
Spectrum Disorders

Mood disorders occur more frequently in family members of individuals with autism spectrum disorders (ASD) than in the general population. There may be associations between maternal mood disorder history patterns and specific ASD phenotypes. We therefore examined the relationship between maternal mood disorders and child autism spectrum disorders in 998 mother-child dyads enrolled in a national online autism registry and database. Mothers of children with ASD completed online questionnaires addressing their child’s ASD as well as their own mood disorder history. In multivariate logistic regression models of ASD diagnoses, the odds of an Asperger disorder versus autistic disorder diagnosis were higher among those children whose mothers had a lifetime history of bipolar disorder (OR 2.11, CI 1.20, 3.69) or depression (OR 1.62, CI 1.19, 2.19). Further, maternal mood disorder onset before first pregnancy was associated with higher odds (OR 2.35, CI 1.48, 3.73) of an Asperger versus autism diagnosis among this sample of children with ASD. These data suggest that differences in maternal mood disorder history may be associated with ASD phenotype in offspring.

scholarly journals 0757 Increasing Number of Cases Who Had Both Hypersomnolence Disorders and Developmental Disorders With Orexin Measurements

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A288-A288
Author(s):  
A Imanishi ◽  
K Yoshizawa ◽  
K Tsutsui ◽  
Y Omori ◽  
T Ono ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Developmental Disorders ◽  
Developmental Disorder ◽  
Clinical History ◽  
Autism Spectrum ◽  
Hyperactivity Disorder ◽  
History Of ◽  
The Relationship

Abstract Introduction Recently, attention has been paid to the relationship between developmental disorders such as attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), and sleep disorders. We meet many developmental disorder patients who complaint hypersomnolence. Among these patients, cases with coexistence of central hypersomnia and developmental disorders, or developmental disorder alone were increased. Therefore, we first investigated patients with the complaint of hypersomnolence, who were also suspected developmental disorders. Furthermore, we have been measuring CSF orexin in 17 cases suspected of both disorders to investigate orexin levels of these patients. Methods 86patients who complained of EDS with suspicion of developmental disorders had been examined. In order to diagnose hypersomnolence disorders, PSG and MSLT were performed. Psychological examinations were performed for diagnosing developmental disorders.We have been measuring for CSF orexin in 17 cases suspected both hypersomnolence and developmental disorders. We examined the onset of hypersomnolence and the clinical history of these ADHD or ASD cases for more details. Results In 86 examined cases, developmental disorders coexisted in 30 cases. Among 30 cases, ADHD were 18, ASD were 6 and both diagnosed were 6 cases. Among them, 20 cases diagnosed as having coexistence of hypersomnia (8: narcolepsy, 12: IHS) and developmental disorders (ADHD:12, ASD:4, ADHD/ASD:4). In 17 cases with orexin measurements, 10 cases coexisted ADHD and 4 cases coexisted ASD. Two cases diagnosed as both ADHD and ASD. In 10 ADHD cases, 3 cases had low orexin levels, and 7 cases had normal orexin levels. Other 7 ASD cases had normal orexin levels. Conclusion ADHD has a higher rate of central hypersomnia (12/18) compared with ASD and the rate of narcolepsy was also high (5/12). While patients in ASD was diagnosed as IHS (3/6), narcolepsy cases were not observed. It became clear that the majority of patients had developmental disorder or had a tendency for developmental disorder before the onset of hypersomnolence.Although it is possible that ADHD/ASD symptoms may be exacerbated by orexin dysfunctions, ADHD/ASD may not newly occur. There were cases with low orexin levels, but it seems that narcolepsy happened to coexist with developmental disorders. Support a

scholarly journals Regression in Conditions of Play Activity in Children with Autistic Spectrum Disorders

2016 ◽  
Vol 24 (1) ◽  
pp. 64-79
Author(s):  
R.A. Turevskaya ◽  
I.M. Bannikova
Keyword(s):  
Developmental Disorder ◽  
Role Playing ◽  
Autism Spectrum ◽  
Play Behavior ◽  
Play Activity ◽  
Adoption Of Innovations ◽  
Children With Asd ◽  
Number Of Factors ◽  
Spectrum Disorders ◽  
Role Playing Game

The study of regression in autism spectrum disorders (ASD) is of particular importance, since it gets us closer to understanding some of the key mechanisms of ASD and makes it possible to operationalize the «penetrating» nature of this developmental disorder. The research uses the model of play behavior to study regressive episodes, which are associated with digression in the level of regulation by meanings and in deliberate organization of play behavior. The purpose of this study is to identify the factors and conditions that cause regressive behavior in children with ASD. Participants: preschool children (5—7 years old) — 18 children with ASD (4 girls and 14 boys) and 18 controls (5 girls and 13 boys). For the purposes of the research a role-playing game had been developed. The game consisted of four stages, in each stage a specific task was assigned to the child. Based on the results of the study a number of factors were revealed that provoke regressive behaviors and affect their number, among them: adoption of innovations, task switching, exhaustion, sensitivity to emotional stress.

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