scholarly journals COVID-19: An insight into the developments in diagnostics and therapeutics in India

2020 ◽  
Vol 72 ◽  
pp. 77-82 ◽  
Author(s):  
Vishal Rao ◽  
Swetha Kannan ◽  
Jitendra Kumar ◽  
Gururaj Arakeri ◽  
Anand Subash ◽  
...  

The unexpected pandemic set off by the novel coronavirus (SARS-CoV2) has spread to more than 210 countries across the globe, including India. In the current pandemic situation, various steps have been taken by the Indian government to prevent and control the spread of the SARS-CoV2 infection. To date, there are no proven vaccines or effective therapeutic interventions against the virus. Current clinical management includes infection prevention and control, symptom-specific relief and supportive care. Physicians and scientists across the country have been tirelessly working on developing effective diagnostic and therapeutic strategies and to combat and control this infection. As the demand for diagnostics and therapeutics continues to rise in India and around the globe, it is essential to rapidly develop various algorithms to successfully identify and contain the virus. This review discusses the updates on the recent developments in COVID-19 diagnostics and therapeutics in India.

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0253068
Author(s):  
Angela Sloan ◽  
Todd Cutts ◽  
Bryan D. Griffin ◽  
Samantha Kasloff ◽  
Zachary Schiffman ◽  
...  

The novel coronavirus, SARS-CoV-2, has spread into a pandemic since its emergence in Wuhan, China in December of 2019. This has been facilitated by its high transmissibility within the human population and its ability to remain viable on inanimate surfaces for an extended period. To address the latter, we examined the effect of simulated sunlight on the viability of SARS-CoV-2 spiked into tissue culture medium or mucus. The study revealed that inactivation took 37 minutes in medium and 107 minutes in mucus. These times-to-inactivation were unexpected since they are longer than have been observed in other studies. From this work, we demonstrate that sunlight represents an effective decontamination method but the speed of decontamination is variable based on the underlying matrix. This information has an important impact on the development of infection prevention and control protocols to reduce the spread of this deadly pathogen.


2020 ◽  
Vol 53 (1) ◽  
pp. 43-55
Author(s):  
William Marty Martin ◽  
Yvette Lopez ◽  
Thomas P. Flannery ◽  
Bill Dixon

Infectious diseases at work can be endemic such as seasonal influenza and emerging such as the novel coronavirus 2019. Infectious diseases have an impact on employees and other types of workers. Compensation and benefits professionals are often at the forefront of preventing workplace infections, addressing workplace infections, and ensuring the continuity of talent when workplace outbreaks and business shutdowns occur. This article provides an overview of pertinent laws, key compensation decisions, and ways to refocus existing benefit programs to meet the challenge of not only just safety, health, and wellness but also infection prevention and control.


2020 ◽  
Author(s):  
Angela Sloan ◽  
Todd Cutts ◽  
Bryan D Griffin ◽  
Samantha Kasloff ◽  
Zachary Schiffman ◽  
...  

Abstract The novel coronavirus, SARS-CoV-2, has spread into a pandemic since its emergence in Wuhan, China in December of 2019. This has been facilitated by its high transmissibility within the human population and its ability to remain viable on inanimate surfaces for an extended period. To address the latter, we examined the ability of sunlight to degrade SARS-CoV-2 on stainless steel. All assays were performed using a solar simulator at the equivalent of one air mass (i.e. equatorial sun at its Zenith). Heat-controlled experiments were conducted at approximately 34% relative humidity (RH); otherwise, RH decreased with sunlight exposure until a constant temperature was maintained. When initially suspended in tissue culture medium, the virus was rendered non-viable after two hours of sunlight exposure. However, when suspended in an organic matrix designed to mimic bodily secretions, three hours of continuous sunlight was required for complete degradation. From this work, we demonstrate that sunlight represents an effective decontamination method but the speed of decontamination is variable based on the underlying matrix. This information has an important impact on the development of infection prevention and control protocols to reduce the spread of this deadly pathogen.


2021 ◽  
Vol 3 (2) ◽  
pp. 134-145
Author(s):  
Wellington Pereira Lopes ◽  
Ludmila Ichioka ◽  
Viviane Micheli Amaral ◽  
Glilciane Morceli ◽  
Marselle Nobre Carvalho

No dia 11 de março de 2020 a Organização Mundial da Saúde declarou oficialmente a pandemia da Covid-19. Essa declaração se deu não pela gravidade da patologia, mas pelo grande poder de contágio do vírus causador da doença. Por esse motivo, todos os países se viram frente um novo desafio de saúde mundial tendo a necessidade de se organizar para enfrentar essa nova demanda por meio da criação de novos fluxos, monitoramento interno dos profissionais e pacientes, e monitoramento externo dos mesmos. Além disso, por se tratar de um vírus com novas características, diversas pesquisas foram publicadas em tempo real a pandemia trazendo novas informações uteis para o trabalho, por esse motivo, o projeto Safety  foi criado com intuito de captar essas novas publicações, avaliar e posteriormente, inserir essas informações no trabalho proporcionando novas ferramentas de enfrentamento de acordo com a aplicabilidade no Brasil. REZENDE, JM. À sombra do plátano: crônicas de história da medicina [online]. São Paulo: EditorUnifesp, 2009. As grandes epidemias da história. pp. 73-82. ISBN 978-85-61673-63-5. Available from SciELO Books http://books.scielo.org.   ZHU, D et al. Um novo coronavírus de paciente com pneumonia na China em 2019. The New England Journal of medicine. Disponível em: https://www.nejm.org/doi/full/10.1056/nejmoa2001017, acessado dia 04/06/2020.   Organização Mundial da Saúde . Coronavírus Novel - China . Genebra, Suíça : Organização Mundial de Saúde , 12 de Janeiro de , 2020 . Https://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/.   FREITAS, AR; NAPIMOGA, M; DONALISIO, MR. Análise da gravidade da pandemia de Covid-19.Epidemiol. Serv. Saúde,  Brasília ,  v. 29, n. 2,  e2020119,    2020 .   Available from <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S223796222020000200900&lng=en&nrm=iso>. access on  04  June  2020.  Epub Apr 06, 2020.  http://dx.doi.org/10.5123/s1679-49742020000200008.   FILHO, JMJ et al . A saúde do trabalhador e o enfrentamento da COVID-19. Rev. bras. saúde ocup.,  São Paulo ,  v. 45,  e14,    2020 .   Available from <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S030376572020000100100&lng=en&nrm=iso>. access on  04  June  2020.  Epub Apr 17, 2020.  http://dx.doi.org/10.1590/2317-6369ed0000120.   BRASIL. Ministério da saúde. Secretária de Vigilância em Saúde. Covid 19. 2020. https://covid.saude.gov.br/.   7.COFEN. Conselho Federal de Enfermagem. Registra 10 mil casos de Covid 19 entre profissionais de enfermagem. 2020. http://www.cofen.gov.br/cofen-registra-10-mil-casos-de-covid-19-entre-profissionais-de-enfermagem_79551.html.   CDC. Centro de Controle de Doenças Infecciosas. Divisão de Doenças Virais dos EUA. https://www.cdc.gov/coronavirus/2019-ncov/hcp/ambulatory-care-settings.html.   9.BRASIL Ministério da Saúde. Protocolo de Manejo Clínico do Coronavírus (Covid 19) Na Atenção Primária a Saúde Versão 8. Disponível em Abril 2020.  http://189.28.128.100/dab/docs/portaldab/documentos/20200422_ProtocoloManejo_ver08.pdf.   PORTUGAL Direção Geral da Saúde. Abordagem do Doente com Suspeita ou Infeção por SARS-CoV-2. Norma nº 004/2020 de 23/03/2020 atualizada a 25/04/2020https://www.dgs.pt/directrizes-da-dgs/normas-e-circulares normativas/norma-n-0042020-de-23032020-pdf.aspx   ESPANHA Ministerio de Sanidad. Procedimiento de Actuación para los Servicios de Prevención de Riesgos Laborales frente a la Exposición AL SARS‐cov‐2. Junho, 2020.https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov-China/documentos/PrevencionRRLL_COVID-19.pdf   12.UK. Guidance Transmission Characteristics and Principles of Infection Prevention and Control. Public Health England. July 2020. https://w ww.gov.uk/government/publications/wuhan-novel-coronavirus-infection prevention-and-control/transmission-characteristics-and-principles-of-infection-prevention-and-control.   13. UK.  Reducing the risk of transmission of COVID-19 in the hospital setting. Public Health England. July 2020. https://www.gov.uk/government/publications/wuhan-novel-coronavirus-infection-prevention-and-control/reducing-the-risk-of-transmission-of-covid-19-in-the-hospital-setting


Author(s):  
Ariful Bashera ◽  
Debashish Das ◽  
M Abul Faiz

The coronavirus disease 2019 (COVID-19) is now a pandemic with a massive death toll across the world. The knowledge and understanding of this novel coronavirus transmission and pathogenesis are evolving. Although the landscape of vaccine and drug development is changing at an unprecedented pace, currently, there is no specific effective treatment. Proper and timely management of severe and critically ill COVID-19 patients is crucial to reduce deaths in the ongoing pandemic. Ramping up testing capacity alongside a test strategy in place, ensuring adequate resources, i.e., protective gear, O2 supply, ICU facilities are essential requirements in the fight against COVID-19. Infection prevention and control measures at a personal level (e.g., handwashing, wearing masks, proper donning and doffing of personal protective equipment), and at hospital settings (e.g., hospital cleanliness, safe handling, and disposal of waste) are extremely important to reduce the risk of infection. COVID-19 pandemic has caused a global crisis that requires a multidisciplinary response and concerted effort to ensure resilience in health systems. J Bangladesh Coll Phys Surg 2020; 38(0): 84-90


Author(s):  
Wei Liu ◽  
Xiao-Guang Yue ◽  
Paul B. Tchounwou

The ongoing outbreak of the novel coronavirus disease (COVID-19) that occurred in China is rapidly spreading globally. China’s bond and strict containment measures have been proved (in practice) to significantly reduce the spread of the epidemic. This was obtained through the use of emergency control measures in the epidemic areas and the integration of resources from multiple systems, including business, community, technology, education, and transportation, across the country. In order to better understand how China has managed to reduce the public health and economic impacts of the COVID-19 epidemic, this editorial systematically reviews the specific measures for infection prevention and control of the disease. The best practices for COVID-19 eradication in China provide evidence-based strategies that could be replicated in other countries.


Author(s):  
Yun ZHOU ◽  
Jing-Jing FANG ◽  
Shan-Shan WANG

Background: To explore the homogenized management method of infection prevention and control in medical resident under COVID-19 epidemic situation. Methods: Overall, 268 members in Ningbo Medical Group which was participating in the management of novel coronavirus pneumonia in Wuhan, China were managed homogeneously in terms of personal cleaning and disinfection of articles, prevention and control of infection in life, training and assessment of relevant infection knowledge in hospitals. Results: In the epidemic situation, the homogenization management of infection prevention and control in the resident of medical team is an important measure to block the transmission link. Conclusion: 1. Conduct homogenization management on the training of hospital infection knowledge for medical staff. 2. Conduct homogeneous management of effective assessment of training knowledge. 3. Conduct homogenization management from personal cleaning and disinfection, as well as infection prevention and control in daily life.


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