scholarly journals Clinical Ratings of Pain Sensitivity Correlate With Quantitative Measures in People With Chronic Neck Pain and Healthy Controls: Cross-Sectional Study

2015 ◽  
Vol 95 (11) ◽  
pp. 1536-1546 ◽  
Author(s):  
Trudy Rebbeck ◽  
Niamh Moloney ◽  
Roxanne Azoory ◽  
Markus Hübscher ◽  
Robert Waller ◽  
...  
Keyword(s):  
Neck Pain ◽  
Pain Sensitivity ◽  
Chronic Neck Pain ◽  
Cross Sectional Study ◽  
Control Groups ◽  
Cross Sectional ◽  
Pressure Pain ◽  
Clinical Correlate ◽  
Pain Test ◽  
And Control

Background Correlations between clinical and quantitative measures of pain sensitivity are poor, making it difficult for clinicians to detect people with pain sensitivity. Clinical detection of pain sensitivity is important because these people have a different prognosis and may require different treatment. Objective The purpose of this study was to investigate the relationship between clinical and quantitative measures of pain sensitivity across individuals with and without neck pain. Methods This cross-sectional study included 40 participants with chronic neck pain and 40 age- and sex-matched controls. Participants underwent quantitative sensory testing of cold pain thresholds (CPTs) and pressure pain thresholds (PPTs). Clinical tests for pain sensitivity were the ice pain test and the pressure pain test. All tests were undertaken at standardized local (neck and upper trapezius muscles) and remote (wrist and tibialis anterior muscles) sites. Median and interquartile range (IQR) were calculated for neck pain and control groups, and parametric and nonparametric tests were used to compare groups. Correlation coefficients were calculated between quantitative and clinical measures. Results There were significant differences for clinical and quantitative measures of cold and pressure sensitivity between the neck pain and control groups (eg, CPT neck pain group: median=22.31°C, IQR=18.58°C; control group: median=5.0°C, IQR=0.74°C). Moderate-to-good correlations were found between the clinical ice pain test and CPT at all sites (.46 to .68) except at the wrist (.29 to .40). Fair correlations were found for the clinical pressure pain test and PPT (−.26 to −.45). Psychological variables contributing to quantitative measures of pain sensitivity included catastrophization, sleep quality, and female sex. Limitations Clinical pressure pain tests were not quantitatively standardized in this study. Conclusions The ice pain test may be useful as a clinical correlate of CPT at all sites except the wrist, whereas the pressure pain test is less convincing as a clinical correlate of PPT.

scholarly journals The Effect of Pressure Pain Sensitivity and Patient Factors on Self-Reported Pain-Disability in Patients with Chronic Neck Pain

2014 ◽  
Vol 8 (1) ◽  
pp. 302-309 ◽  
Author(s):  
Zakir Uddin ◽  
Joy C. MacDermid ◽  
Linda J. Woodhouse ◽  
John J. Triano ◽  
Victoria Galea ◽  
...  
Keyword(s):  
Neck Pain ◽  
Pain Sensitivity ◽  
Chronic Neck Pain ◽  
Cross Sectional Study ◽  
Patient Factors ◽  
Cross Sectional ◽  
Pressure Pain ◽  
Pain Disability ◽  
Mean Differences ◽  
Neck Disability

The study was conducted to estimate the extent to which pressure pain sensitivity (PPS) and patient factors predict pain-related disability in patients with neck pain (NP), and to determine if PPS differs by gender. Forty-four participants with a moderate level of chronic NP were recruited for this cross sectional study. All participants were asked to complete self-reported assessments of pain, disability and comorbidity and then underwent PPS testing at 4-selected body locations. Pearson`s r w was computed to explore relationships between the PPS measures and the self-reported assessments. Regression models were built to identify predictors of pain and disability. An independent sample t-test was done to identify gender-related differences in PPS, pain-disability and comorbidity. In this study, greater PPS (threshold and tolerance) was significantly correlated to lower pain-disability (r = -.30 to -.53, p≤0.05). Age was not correlated with pain or disability but comorbidity was (r= 0.42-.43, p≤0.01). PPS at the 4-selected body locations was able to explain neck disability (R2=25-28%). Comorbidity was the strongest predictor of neck disability (R2=30%) and pain (R2=25%). Significant mean differences for gender were found in PPS, disability and comorbidity, but not in pain intensity or rating. This study suggests that PPS may play a role in outcome measures of pain and disability but between-subject comparisons should consider gender and comorbidity issues.

Comparison and Association of Neck Extensor Muscles’ Endurance and Postural Function in Subjects with and without Chronic Neck Pain – A Cross-Sectional Study

2021 ◽  
Author(s):  
Praveen Kumar Kandakurti ◽  
Ravi Shankar Reddy ◽  
Venkata Nagaraj Kakarparthy ◽  
Kanagaraj Rengaramanujam ◽  
Jaya Shanker Tedla ◽  
...  
Keyword(s):  
Neck Pain ◽  
Postural Control ◽  
Chronic Neck Pain ◽  
Cross Sectional Study ◽  
Control Measures ◽  
Endurance Capacity ◽  
Control Parameters ◽  
Sectional Study ◽  
Cross Sectional ◽  
Velocity Moment

Abstract Purpose Neck extensor endurance (NEE) and position sense are vital for maintaining cervical spine function and defects in these processes may be associated with impaired postural control in chronic neck pain (CNP) subjects. The study’s objectives are 1) to compare the cervical extensor endurance capability and postural control of CNP subjects with those of asymptomatic controls; 2) to investigate the association between NEE and postural control. Materials and Methods Sixty-four participants (38 asymptomatic, 38 with CNP) participated in this cross-sectional study. NEE was assessed using a clinical extensor endurance test. Under open and closed eyes conditions, postural control measures were tested with the Good Balance system. The postural control parameters were AP-velocity (mm/s), ML-velocity (mm/s) and Velocity moment (mm2). NEE capacity and postural control parameters were compared and correlated between asymptomatic and CNP subjects. Results and Discussion CNP subjects showed lower NEE capacity (p<0.001) and significantly larger AP-velocity (p<0.001), ML-velocity (p<0.001) and Velocity moment (p<0.001) than asymptomatic participants. NEE negatively correlated with AP-velocity (r=−0.51, p=0.001), ML-velocity (r=0.46, p=0.003) and velocity moment (r=0.38, p=0.020) in asymptomatic subjects in eyes open condition and no correlations in subjects with CNP. CNP subjects showed increased postural sway velocities and lowered extensor endurance capacity compared to asymptomatic participants. No correlations existed between NEE and postural control parameters in CNP subjects.

scholarly journals Influence of etanercept on leptin and ghrelin secretion in children with juvenile idiopathic arthritis

2017 ◽  
Vol 45 (2) ◽  
pp. 525-532 ◽  
Author(s):  
Izabela Maciejewska-Paszek ◽  
Elżbieta Grochowska-Niedworok ◽  
Andrzej Siwiec ◽  
Anna Gruenpeter ◽  
Lechosław Dul ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Conventional Treatment ◽  
Cross Sectional Study ◽  
Control Groups ◽  
Cross Sectional ◽  
Total Ghrelin ◽  
Low Bmi ◽  
Acyl Ghrelin ◽  
And Control ◽  
Ghrelin Secretion

Objective To assess possible changes in leptin and ghrelin secretion due to etanercept in juvenile idiopathic arthritis (JIA). Methods 50 patients with JIA and 16 age-matched controls were enrolled into this prospective, cross-sectional study. Serum leptin, total and acyl ghrelin were measured in addition to white blood cell (WBC) and lymphocyte counts. Results 25 patients received etanercept and 25 conventional therapies (including methotrexate) for JIA. There was no difference between treatment and control groups in leptin or ghrelin levels and no evidence of a relationship between leptin and ghrelin in patients with JIA. In all children with JIA there was a correlation between leptin and body mass index (BMI). However, compared with children in the conventional treatment group, children in the etanercept group showed a positive correlation between total ghrelin and BMI and those with a low BMI showed a negative correlation between acyl ghrelin and BMI. Conclusion No differences in leptin and ghrelin concentrations were found when patients with JIA and controls were compared or when patients who received etanercept were compared with those who received conventional treatment for JIA.

scholarly journals Alteration of Screw-home Movement in Patients With Knee Osteoarthritis: A Cross-sectional Study

2020 ◽  
Author(s):  
Jeongwoo Jeon ◽  
Dongyeop Lee ◽  
Jaeho Yu ◽  
Jinseop Kim ◽  
Sang Hoon Lhee ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Knee Extension ◽  
Cross Sectional Study ◽  
Measurement Unit ◽  
Tibial Rotation ◽  
Sectional Study ◽  
Control Groups ◽  
Cross Sectional ◽  
Knee Oa ◽  
And Control

Abstract Background: Tibial rotation accompanying sagittal movement contains the phenomenon of screw-home movement of the knee, which plays an important role in knee stability during extension. This study aimed to investigate the alteration of screw-home movement in patients with knee osteoarthritis (OA).Methods: Participants (n =67) in this cross-sectional study were outpatients in the department of orthopedics of a general hospital and included patients with knee OA (n=31) and asymptomatic control subjects (n=36).Knee kinematic data were measured using an inertial measurement unit. The total tibial rotation was obtainedduring knee sagittal movement. The acquired angle of tibial rotation was divided into four periodseach extension and flexion. The total tibial rotation and the variation of each period were compared between the OA and control groups.Results: Significant differences arose between the OA and control groups in the total tibial rotation during knee extension and flexion(P< 0.001).The variation of tibial rotation was also significantly different between groups for all periods (P< 0.001; knee extensionat 70° to 45°,P = 0.014).Conclusions: We found a reduction in the total tibial rotation and loss of the screw-home movement in the unloaded OA knee. To normalize the screw-home movement, it is necessary to promote proper articular movement of the knee joint and suppress the hyperexcitability of the medial muscles.

scholarly journals The relationship between the TSH values and the Tpeak – Tend interval duration in hypothyroid patients receiving Levothyroxine treatment

2019 ◽  
Vol 57 (2) ◽  
pp. 175-180
Author(s):  
Hüseyin Avni Findikli ◽  
Ayşe Şahin Tutak ◽  
Hakan Aydin
Keyword(s):  
Hormone Level ◽  
Cross Sectional Study ◽  
Healthy Individuals ◽  
Sectional Study ◽  
Control Groups ◽  
Cross Sectional ◽  
And Control ◽  
The Relationship ◽  
Hypothyroid Patients ◽  
Levothyroxine Treatment

Abstract Introduction. Changes in thyroid hormone level can affect the cardiovascular system. The aim of this study was to show how the Tpeak -Tend (Tpe) interval, which is a new marker of ventricular arrythmia, is affected in patients who have become euthyroid following Levothyroxine treatment for hypothyroidism, as this has not been examined previously in literature. Materials and Methods. This, cross-sectional study included a total of 119 females aged 18-45 years, separated into 3 groups as hypothyroid, euthyroid and control groups. For evaluation of the QTc and Tpe intervals, examination on precordial V5 lead was made of all the ECGs taken routinely on presentation of the patients. Results. The Tpe and QTc intervals of the hypothyroid group were determined to be significantly prolonged compared to those of the euthyroid and control groups (p < 0.001) and the values of the euthyroid and control groups were similar. A positive correlation was determined between TSH levels and Tpe and QTc intervals. Tpe interval AUC = 0.801 (%95 CI: 0.719 – 0.884) was higher than that of QTc AUC = 0.689 (%95 CI: 0.591 – 0.786). Conclusions. The Tpe duration was evaluated in respect of the risk of arrythmia in hypothyroid patients. In patients who had become euthyroid, the Tpe interval was found to be similar to that of healthy individuals and was more predictive than QTc. In the light of these findings it can be recommended that measurement of the Tpe interval should be preferred to QTc as a marker of the arrythmogenic effect in hypothyroid patients.

scholarly journals Immunological Microenvironment Alterations in Follicles of Patients With Autoimmune Thyroiditis

2021 ◽  
Vol 12 ◽  
Author(s):  
Ning Huang ◽  
Dandan Liu ◽  
Ying Lian ◽  
Hongbin Chi ◽  
Jie Qiao
Keyword(s):  
Follicular Fluid ◽  
Autoimmune Thyroiditis ◽  
Cross Sectional Study ◽  
Control Group ◽  
Control Groups ◽  
Cross Sectional ◽  
Thyroid Autoantibody ◽  
Inflammatory Cascade ◽  
Immune Imbalance ◽  
And Control

Autoimmune thyroiditis (AIT) is the most prevalent autoimmune endocrine disease, with a higher incidence in women than in men. Immunological abnormalities may lead to the impairment of ovarian folliculogenesis; however, whether the presence of AIT affects immunological microenvironment in follicles remains controversial. We performed a cross-sectional study including 122 patients, aged 20–40 years, who underwent IVF/ICSI treatment owing to isolated male or tube factor infertility. Patients were divided into AIT and control groups according to clinical presentation, thyroid function, and thyroid autoantibody measurements. Follicular fluid was collected and the distribution of cytokines/chemokines in follicular fluid was measured by flow cytometry using multiplex bead assays between the two groups. Based on differences in levels of intrafollicular chemokines and cytokines between the AIT and control groups, the relevant inflammatory cascade was further demonstrated. Among the 12 chemokines analyzed, three (CXCL9, CXCL10, and CXCL11) showed significantly elevated levels in the follicular fluid of patients with AIT. Among the 11 cytokines detected, compared with those in the control group, significantly higher levels of IFNγ were observed in patients with AIT. IFNγ dose-dependently stimulated the expression and secretion of CXCL9/10/11 in cultured primary granulosa cells. The percentage of CXCR3+ T lymphocytes was significantly elevated in the follicular microenvironment of patients with AIT. We concluded that the IFNγ-CXCL9/10/11-CXCR3+ T lymphocyte inflammatory cascade is activated in the follicular microenvironment of patients with AIT. These findings indicate that a considerable immune imbalance occurred in the follicular microenvironment of patients with AIT.

Interactive Association Between Mechanical and Sensorimotor Aspects of Cervical Extensor Muscles: Implications for Chronic Neck Pain

2020 ◽  
Vol 36 (4) ◽  
pp. 190-197
Author(s):  
Leila Ghamkhar ◽  
Somayeh Amiri Arimi ◽  
Amir H. Kahlaee
Keyword(s):  
Neck Pain ◽  
Odds Ratio ◽  
Chronic Neck Pain ◽  
Cross Sectional Study ◽  
Transverse Plane ◽  
Muscle Size ◽  
Sectional Study ◽  
Multifidus Muscle ◽  
Cross Sectional ◽  
Extensor Muscles

While proprioceptive functioning of the cervical extensor muscles has been proposed to be associated with chronic neck pain (NP), the mechanism by which such impairment might contribute to NP is not clear. The aim of this cross-sectional study was to investigate the relevance of proprioception, extensor muscles size, and endurance to chronic NP. A total of 60 participants with (n = 30) or without (n = 30) chronic NP participated in this cross-sectional study. Joint repositioning error (JRE), ultrasonographic parameters of the cervical extensors, and clinical extensor endurance were assessed. Multivariate analysis of variance and logistic regression tests were used to compare the groups and test the predictive value of the dependent variables for chronic NP, respectively. Patients showed comparable JRE scores but smaller multifidus size and lower extensor endurance (Cohen d = 0.66 for both). JRE in the transverse plane (β = 1.20), multifidus muscle size (β = 0.02), and endurance (β = 0.99) were significant predictors for chronic NP odds ratio. The results found multifidus size as the most relevant factor to NP by showing both between-groups difference and considerable odds ratio. As JRE in transverse plane was not different between the groups and extensor endurance demonstrated minimal odds ratio, these 2 factors may be considered as less relevant to NP comparing multifidus muscle size.

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