scholarly journals Lower Physical Activity Is Associated With Higher Intermuscular Adipose Tissue in People With Type 2 Diabetes and Peripheral Neuropathy

2011 ◽  
Vol 91 (6) ◽  
pp. 923-930 ◽  
Author(s):  
Lori J. Tuttle ◽  
David R. Sinacore ◽  
W. Todd Cade ◽  
Michael J. Mueller
Keyword(s):  
Physical Activity ◽  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Peripheral Neuropathy ◽  
Intermuscular Adipose Tissue ◽  
Lower Physical Activity

scholarly journals 4126 Intermuscular adipose tissue secretes pro-inflammatory, extracellular matrix, and lipid signals related to insulin resistance and type 2 diabetes

2020 ◽  
Vol 4 (s1) ◽  
pp. 9-9
Author(s):  
Darcy Kahn ◽  
Simona Zarini ◽  
Emily Macias ◽  
Amanda Garfield ◽  
Kathleen Harrison ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Extracellular Matrix ◽  
Adipose Tissue ◽  
Functional Role ◽  
Vastus Lateralis ◽  
Laparoscopic Bariatric Surgery ◽  
Intermuscular Adipose Tissue

OBJECTIVES/GOALS: Intermuscular adipose tissue (IMAT) has been associated with insulin resistance and type 2 diabetes, yet mechanistic studies addressing the functional role of IMAT are lacking. The aim of this work was to identify novel mechanisms by which IMAT may directly impact skeletal muscle metabolism. METHODS/STUDY POPULATION: We quantified the secretome of IMAT, subcutaneous adipose tissue (SAT), and visceral adipose tissue (VAT) to determine if there are differences between depots in the secretion of cytokines, eicosanoids, FFAs and proteins that influence metabolic function. SAT and VAT biopsies from patients undergoing laparoscopic bariatric surgery and IMAT extracted from vastus lateralis biopsies of individuals with Obesity were cultured for 48 hours in DMEM, and the conditioned media was analyzed using nanoflow HPLC-MS, multiplex ELISAs and LC/MS/MS for proteins, cytokines and eicosanoids/FFA, respectively. RESULTS/ANTICIPATED RESULTS: IMAT secretion of various extracellular matrix proteins (fibrinogen-β, collagenV1a3, fibronectin) was significantly different than VAT and SAT. Pro-inflammatory cytokine secretion of IFNg, TNFa, IL-8 and IL-13 from IMAT was higher than VAT and significantly higher than SAT (p < 0.05). IMAT secretes significantly more pro-inflammatory eicosanoids TXB2 and PGE2 than VAT (p = 0.02, 0.05) and SAT (p = 0.01, 0.04). IMAT and VAT have significantly greater basal lipolysis assessed by FFA release rates compared to SAT (p = 0.01, 0.04). DISCUSSION/SIGNIFICANCE OF IMPACT: These data begin to characterize the disparate secretory properties of SAT, VAT and IMAT and suggest a metabolically adverse secretome of IMAT, that due to its proximity to skeletal muscle may play an important functional role in the pathogenesis of insulin resistance and type 2 diabetes.

AKTIVITAS FISIK PADA PASIEN DIABETES MELITUS TIPE 2 DENGAN NEUROPATI PERIFER : TINJAUAN LITERATUR

2019 ◽  
Vol 3 (1) ◽  
pp. 1-7
Author(s):  
Rima Novia Putri
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Weight Bearing ◽  
Nerve Cells ◽  
Motor Neuropathy

Type 2 diabetes mellitus is a chronic disease that could cause damage to foot peripheral nerves, namely peripheral neuropathy. Diabetic peripheral neuropathy is  a damage and inability to regenerate nerve cells due to exposure of chronic hyperglycemia which can lead to various symptopms and complications. Therapy is aimed at improving symptoms and delaying development of peripheral neuropathy, one of which is physical activity which is one of the cornerstones of management of diabetes mellitus. An explanation of the benefits of physical activity in diabetes mellitus has been widely discussed, but nore in peripheral neuropathy. This literature review aims to explain the types and benefits of physical activity in peripheral neuropathy. Seven literature reviewed were obtained through electronic database search EBSCOHost, Proquest, and Clinical Key with key words physical activity, exercise intervention, diabetic peripheral neuropathy, and type 2 diabetes mellitus. Peripheral neuropathy patients can carry out various types of physical activity, either weight bearing or non-weight bearing exercise. Patients with ulcers, wounds and severe foot deformity can do non-weight bearing exercise such as static cycling and upper body ergometer. Another can do walking, aerobics, balance exercises, stretching, tai chi, resistance training, and foot ankle exercises. Aerobics is a physical activity that can prevent and delay development of peripheral neuropathy. Balance training can improve sensory and motor neuropathy. In general, physical activity can improve innervation in the cutaneous tissue, regenerate nerve cells, improve the symptoms of neuropathy in the form of pain, balance disorders, risk of falls, and obstacles to physical mobility.

scholarly journals Amino Acid Replacement (K14Q) of Mitochondria-Derived MOTS-c Affects Type 2 Diabetes in Men with Lower Physical Activity

2018 ◽  
Vol 64 (Suppl.1) ◽  
pp. 121-121 ◽  
Author(s):  
HIROFUMI ZEMPO ◽  
NORIYUKI FUKU ◽  
HIROSHI KUMAGAI ◽  
YUICHIRO NISHIDA ◽  
YASUKI HIGAKI ◽  
...  
Keyword(s):  
Physical Activity ◽  
Type 2 Diabetes ◽  
Amino Acid ◽  
Amino Acid Replacement ◽  
Lower Physical Activity

scholarly journals Adipose tissue biomarkers and type 2 diabetes incidence in normoglycemic participants in the MESArthritis Ancillary Study: A cohort study

PLoS Medicine ◽  
2021 ◽  
Vol 18 (7) ◽  
pp. e1003700
Author(s):  
Farhad Pishgar ◽  
Mahsima Shabani ◽  
Thiago Quinaglia A. C. Silva ◽  
David A. Bluemke ◽  
Matthew Budoff ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Population Based ◽  
Diabetes Incidence ◽  
Intermuscular Adipose Tissue ◽  
Measurement Protocol ◽  
Tissue Biomarkers

Background Given the central role of skeletal muscles in glucose homeostasis, deposition of adipose depots beneath the fascia of muscles (versus subcutaneous adipose tissue [SAT]) may precede insulin resistance and type 2 diabetes (T2D) incidence. This study was aimed to investigate the associations between computed tomography (CT)–derived biomarkers for adipose tissue and T2D incidence in normoglycemic adults. Methods and findings This study was a population-based multiethnic retrospective cohort of 1,744 participants in the Multi-Ethnic Study of Atherosclerosis (MESA) with normoglycemia (baseline fasting plasma glucose [FPG] less than 100 mg/dL) from 6 United States of America communities. Participants were followed from April 2010 and January 2012 to December 2017, for a median of 7 years. The intermuscular adipose tissue (IMAT) and SAT areas were measured in baseline chest CT exams and were corrected by height squared (SAT and IMAT indices) using a predefined measurement protocol. T2D incidence, as the main outcome, was based on follow-up FPG, review of hospital records, or self-reported physician diagnoses. Participants’ mean age was 69 ± 9 years at baseline, and 977 (56.0%) were women. Over a median of 7 years, 103 (5.9%) participants were diagnosed with T2D, and 147 (8.4%) participants died. The IMAT index (hazard ratio [HR]: 1.27 [95% confidence interval [CI]: 1.15–1.41] per 1-standard deviation [SD] increment) and the SAT index (HR: 1.43 [95% CI: 1.16–1.77] per 1-SD increment) at baseline were associated with T2D incidence over the follow-up. The associations of the IMAT and SAT indices with T2D incidence were attenuated after adjustment for body mass index (BMI) and waist circumference, with HRs of 1.23 (95% CI: 1.09–1.38) and 1.29 (95% CI: 0.96–1.74) per 1-SD increment, respectively. The limitations of this study include unmeasured residual confounders and one-time measurement of adipose tissue biomarkers. Conclusions In this study, we observed an association between IMAT at baseline and T2D incidence over the follow-up. This study suggests the potential role of intermuscular adipose depots in the pathophysiology of T2D. Trial registration ClinicalTrials.gov NCT00005487

How to Maintain a Healthy Body Weight

2006 ◽  
Vol 76 (4) ◽  
pp. 208-215 ◽  
Author(s):  
Astrup
Keyword(s):  
Physical Activity ◽  
Type 2 Diabetes ◽  
Weight Loss ◽  
Body Weight ◽  
Glycemic Index ◽  
Dairy Products ◽  
Weight Control ◽  
Healthy Body Weight ◽  
Healthy Body

The epidemic of both obesity and type 2 diabetes is due to environmental factors, but the individuals developing the conditions possess a strong genetic predisposition. Observational surveys and intervention studies have shown that excess body fatness is the major environmental cause of type 2 diabetes, and that even a minor weight loss can prevent its development in high-risk subjects. Maintenance of a healthy body weight in susceptible individuals requires 45–60 minutes physical activity daily, a fat-reduced diet with plenty of fruit, vegetables, whole grain, and lean meat and dairy products, and moderate consumption of calorie containing beverages. The use of table values to predict the glycemic index of meals is of little – if any – value, and the role of a low-glycemic index diet for body weight control is controversial. The replacement of starchy carbohydrates with protein from lean meat and lean dairy products enhances satiety, and facilitate weight control. It is possible that dairy calcium also promotes weight loss, although the mechanism of action remains unclear. A weight loss of 5–10% can be induced in almost all obese patients providing treatment is offered by a professional team consisting of a physician and dieticians or nurses trained to focus on weight loss and maintenance. Whereas increasing daily physical activity and regular exercise does not significantly effect the rate of weight loss in the induction phase, it plays an important role in the weight maintenance phase due to an impact on daily energy expenditure and also to a direct enhancement of insulin sensitivity.

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