scholarly journals Meta-Analysis of the Relationship Between HLA-DRB1*07and HLA-DRB1*13 Gene Polymorphisms, and Chronic Hepatitis B in Chinese Han Population

2016 ◽  
Vol 1 (1) ◽  
pp. 1
Author(s):  
Yu Gu ◽  
Entao Sun ◽  
Yuee Huang
Keyword(s):  
Risk Factors ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Odds Ratio ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
The Relationship

Objective:To assess the relationship of HLA-DRB1*07 and HLA-DRB1*13 gene polymorphisms with chronic hepatitis B (CHB) in Chinese Han population Methods: A comprehensive search for articles from 2000 to 2015 was conducted from China National Knowledge Infrastructure (CNKI), VIP and Medline databases. Ten epidemiological case-control studies on the relationship between gene polymorphisms of HLA-DRB1*07 and HLA-DRB1*13, and CHB were subjected to meta analysis. Potential publication bias was analyzed with Review Manager 5.3 software and stata software. Results: A total of 838 patients with CHB and 1181 uninfected healthy controls were included from the ten studies. HLA-DRB1*07 alleles were the risk factors of CHB, with pooled odds ratio of 2.09 (95% CI=1.26~3.47;Z=2.86,P<0.01). HLA-DRB1*13 alleles were the protection factors against CHB, and the value of pooled odds ratio was 0.32 (95% CI=0.19~0.57;Z=3.94,P<0.01) Conclusion: CHB is associated with gene polymorphism of HLA-DRB1 in Chinese Han population. HLA-DRB1*07 alleles were the risk factors of CHB, while HLA-DRB1*13 alleles were the protection factors against the disease.

scholarly journals Correlations between ASCC3 Gene Polymorphisms and Chronic Hepatitis B in a Chinese Han Population

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0141861 ◽  
Author(s):  
Lifeng Liu ◽  
Jinliang Zhang ◽  
Yan Lu ◽  
Chunfang Fang ◽  
Senlin Li ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Gene Polymorphisms ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals ZSCAN25 and CYP2E1 polymorphisms is risk factors for ischemic stroke in a Chinese Han population: a case control study

2020 ◽  
Author(s):  
Haozheng Yuan ◽  
Pei Fan ◽  
Li Yao ◽  
Yuying Lv ◽  
Haidong Wei ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Odds Ratio ◽  
Case Control Study ◽  
Case Control ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
The Relationship ◽  
Control Study ◽  
Age And Sex

Abstract Background We aimed to explore the relationship between ZSCAN25 and CYP2E1 polymorphisms and Ischemic stroke (IS) susceptibility among a Chinese Han population. Methods We enrolled 477 patients with IS and 480 age- and sex- matched health controls. Genotyping of the ZSCAN25 rs10242455, CYP2E1 rs2070672 and rs2515641 were performed by Agena MassARRAY platform. Odds ratio (OR) and 95% confidence interval (CI) were calculated by logistic regression analysis. Results Rs10242455 (OR = 0.56, 95% CI: 0.34–0.93, p = 0.024) was associated with a reduced IS susceptibility, while rs2070672 (OR = 1.40, 95% CI: 1.12–1.75, p = 0.003) and rs2515641 (OR = 1.29, 95% CI: 1.01–1.64, p = 0.041) with an increased IS occurrence. Rs2070672 was observed to correlate with IS risk (OR = 4.06, p = 0.038) at age > 64 years, and rs10242455 (OR = 0.45, p = 0.021) and rs2070672 (OR = 3.28, p = 0.024) affected IS risk in males. In addition, rs10242455 (OR = 1.72, p = 0.014) was significantly associated with hypertension in IS patients. Conclusion Our study firstly found that rs10242455 in ZSCAN25, rs2070672 and rs2515641 in CYP2E1 were associated with the occurrence of IS in a Chinese Han population.

scholarly journals The Association Between CTLA-4, CD80/86, and CD28 Gene Polymorphisms and Rheumatoid Arthritis: An Original Study and Meta-Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Weixi Liu ◽  
Zhicheng Yang ◽  
Yan Chen ◽  
Haoyu Yang ◽  
Xiaoxian Wan ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Gene Polymorphism ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Costimulatory Molecule ◽  
Functional Class ◽  
Chinese Han Population ◽  
Nucleotide Polymorphisms ◽  
Chinese Han ◽  
Han Population

Background: Rheumatoid arthritis (RA) is related to several pivotal susceptibility genes, including cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecule (CD80/CD86) genes. Although the connection between polymorphisms of CTLA-4 and CD86 genes in different populations of RA have been studied extensively, the results are controversial.Objective: To clarify the correlation in the Chinese Han population between CTLA-4, CD80/86, and CD28 gene polymorphisms, and RA susceptibility.Methods: A case-control study (574 RA patients and 804 controls) was conducted to determine the correlation between CTLA-4 rs231775 and rs16840252 gene polymorphisms, CD86 rs17281995 gene polymorphisms, and the risk of RA for the Chinese Han population. Furthermore, an additional meta-analysis, including three single nucleotide polymorphisms (SNPs) (CTLA-4 rs231775, CTLA-4 rs3087243, and CTLA-4 rs5742909) from 32 citations, including 43 studies, 24,703 cases and 23,825 controls was performed to elucidate the relationship between known SNPs in the CTLA-4 genes and RA for more robust conclusions.Results: The results showed that CTLA-4 rs231775 gene polymorphism decreased the RA risk (GA vs. AA, OR = 0.77, P = 0.025), whereas CTLA-4 rs16840252 and CD86 rs17281995 gene polymorphisms were not related to RA susceptibility. Stratification analyses by RF, ACPA, CRP, ESR, DAS28, and functional class identified significant associations for CTLA-4 rs231775 and rs16840252 gene polymorphisms in the RF-positive and RF-negative groups. A meta-analysis of the literature on CTLA-4 gene polymorphisms and RA risk revealed that the risk of RA was decreased by CTLA-4 rs231775 gene polymorphisms.Conclusions: The CTLA-4 rs231775 gene polymorphism decreased the risk of RA, whereas CTLA-4 rs16840252 and CD86 rs17281995 gene polymorphisms were not related to RA risk. A meta-analysis indicated that CTLA-4 rs231775 and rs3087243 gene polymorphisms decreased the risk of RA. To support these analytical results, additional clinical cases should be investigated in further studies.

Association between SNPs in miRNA-machinery genes and chronic hepatitis B in the Chinese Han population

2014 ◽  
Vol 28 ◽  
pp. 113-117 ◽  
Author(s):  
Mengqiao Shang ◽  
Yanchun Huang ◽  
Xuejiao Hu ◽  
Jun Wang ◽  
Xingbo Song ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals Association of Gene Polymorphisms in APOE and BIN1 With Dementia of Alzheimer's Type Susceptibility in Chinese Han Population

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiaoyue Li ◽  
Yelei Zhang ◽  
Xinyu Chen ◽  
Hongwei Yuan ◽  
Zhiqiang Wang ◽  
...  
Keyword(s):  
Sex Differences ◽  
Gene Polymorphisms ◽  
Chinese Han Population ◽  
Healthy Controls ◽  
Chinese Han ◽  
Han Population ◽  
Increased Risk ◽  
Dementia Of Alzheimer’S Type ◽  
Ε4 Allele ◽  
The Relationship

Objectives: Dementia of the Alzheimer's type (DAT) is the most common chronic neurodegenerative disease. At present, the pathogenesis of DAT is not completely clear, and there are no drugs that can cure the disease. Once an individual is diagnosed with DAT, the survival time is only 3 to 9 years. Therefore, there is an urgent need to determine the etiology of DAT and the associated influencing factors to find a breakthrough in the treatment of DAT.Methods: We studied the relationship between polymorphisms in several genes (including BIN1 and APOE) and DAT susceptibility and the effects of sex differences on DAT. Our study included 137 patients with DAT and 509 healthy controls (HCs).Results: The APOE rs429358 polymorphism CC and CT genotypes were associated with an increased risk of DAT in women. We found a significant association between APOE ε4 and DAT. The frequency of the ε4 allele in the DAT group (15.5%) was higher than that in the HC group (8.7%). The BIN1 rs7561528 polymorphism was associated with a decreased risk of DAT in men.Conclusions: APOE gene rs429358 and BIN1 gene 7561528 genes may affect the susceptibility to DAT in a Chinese Han population.

Sign in / Sign up

Export Citation Format

Share Document