A New Packing Code for Creating Mirostructures of Propellants and Explosives

2015 ◽  
Author(s):  
Guilherme Amadio ◽  
Thomas L. Jackson
Keyword(s):  
Packing Code

scholarly journals Packing of apolar side chains enables accurate design of highly stable membrane proteins

Science ◽  
2019 ◽  
Vol 363 (6434) ◽  
pp. 1418-1423 ◽  
Author(s):  
Marco Mravic ◽  
Jessica L. Thomaston ◽  
Maxwell Tucker ◽  
Paige E. Solomon ◽  
Lijun Liu ◽  
...  
Keyword(s):  
Membrane Proteins ◽  
Hydrophobic Effect ◽  
Side Chain ◽  
Side Chains ◽  
Chain Packing ◽  
Membrane Protein Folding ◽  
Natural Protein ◽  
Accurate Design ◽  
Polar Interactions ◽  
Packing Code

The features that stabilize the structures of membrane proteins remain poorly understood. Polar interactions contribute modestly, and the hydrophobic effect contributes little to the energetics of apolar side-chain packing in membranes. Disruption of steric packing can destabilize the native folds of membrane proteins, but is packing alone sufficient to drive folding in lipids? If so, then membrane proteins stabilized by this feature should be readily designed and structurally characterized—yet this has not been achieved. Through simulation of the natural protein phospholamban and redesign of variants, we define a steric packing code underlying its assembly. Synthetic membrane proteins designed using this code and stabilized entirely by apolar side chains conform to the intended fold. Although highly stable, the steric complementarity required for their folding is surprisingly stringent. Structural informatics shows that the designed packing motif recurs across the proteome, emphasizing a prominent role for precise apolar packing in membrane protein folding, stabilization, and evolution.

scholarly journals An Amino Acid Packing Code for α-Helical Structure and Protein Design

2012 ◽  
Vol 419 (3-4) ◽  
pp. 234-254 ◽  
Author(s):  
Hyun Joo ◽  
Archana G. Chavan ◽  
Jamie Phan ◽  
Ryan Day ◽  
Jerry Tsai
Keyword(s):  
Amino Acid ◽  
Protein Design ◽  
Helical Structure ◽  
Packing Code

scholarly journals Parallel packing code for propellant microstructure analysis

2015 ◽  
Vol 46 ◽  
pp. 484-492 ◽  
Author(s):  
Alessandro Baietta ◽  
Filippo Maggi
Keyword(s):  
Microstructure Analysis ◽  
Packing Code

Aluminum Agglomeration Modeling Using a Packing Code

2008 ◽  
Author(s):  
Filippo Maggi ◽  
Thomas Jackson ◽  
John Buckmaster
Keyword(s):  
Packing Code

scholarly journals Protein Packing Code for DNA Recognition Based on the Knob-Socket Model

2016 ◽  
Vol 110 (3) ◽  
pp. 240a
Author(s):  
Hyun Joo ◽  
Vivian Chen ◽  
Sruti Elson ◽  
Jerry Tsai
Keyword(s):  
Dna Recognition ◽  
Protein Packing ◽  
Packing Code
Sign in / Sign up

Export Citation Format

Share Document