Modeling Membrane Displacements in the Sonic Fatigue Response Prediction Problem

Author(s):  
Joseph Hollkamp ◽  
Robert Gordon
2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Zachary Stanfield ◽  
Mustafa Coşkun ◽  
Mehmet Koyutürk

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Zachary Stanfield ◽  
Mustafa Coşkun ◽  
Mehmet Koyutürk

Abstract Drug response prediction is a well-studied problem in which the molecular profile of a given sample is used to predict the effect of a given drug on that sample. Effective solutions to this problem hold the key for precision medicine. In cancer research, genomic data from cell lines are often utilized as features to develop machine learning models predictive of drug response. Molecular networks provide a functional context for the integration of genomic features, thereby resulting in robust and reproducible predictive models. However, inclusion of network data increases dimensionality and poses additional challenges for common machine learning tasks. To overcome these challenges, we here formulate drug response prediction as a link prediction problem. For this purpose, we represent drug response data for a large cohort of cell lines as a heterogeneous network. Using this network, we compute “network profiles” for cell lines and drugs. We then use the associations between these profiles to predict links between drugs and cell lines. Through leave-one-out cross validation and cross-classification on independent datasets, we show that this approach leads to accurate and reproducible classification of sensitive and resistant cell line-drug pairs, with 85% accuracy. We also examine the biological relevance of the network profiles.


2005 ◽  
Vol 284 (3-5) ◽  
pp. 1145-1163 ◽  
Author(s):  
Joseph J. Hollkamp ◽  
Robert W. Gordon ◽  
S. Michael Spottswood

2017 ◽  
Vol 22 (5-6) ◽  
pp. 389-401 ◽  
Author(s):  
Yu Yang ◽  
Catherine R. Miller ◽  
Antonio Lopez-Beltran ◽  
Rodolfo Montironi ◽  
Monica Cheng ◽  
...  

2018 ◽  
Vol 84 (11) ◽  
pp. 74-87
Author(s):  
V. B. Bokov

A new statistical method for response steepest improvement is proposed. This method is based on an initial experiment performed on two-level factorial design and first-order statistical linear model with coded numerical factors and response variables. The factors for the runs of response steepest improvement are estimated from the data of initial experiment and determination of the conditional extremum. Confidence intervals are determined for those factors. The first-order polynomial response function fitted to the data of the initial experiment makes it possible to predict the response of the runs for response steepest improvement. The linear model of the response prediction, as well as the results of the estimation of the parameters of the linear model for the initial experiment and factors for the experiments of the steepest improvement of the response, are used when finding prediction response intervals in these experiments. Kknowledge of the prediction response intervals in the runs of steepest improvement of the response makes it possible to detect the results beyond their limits and to find the limiting values of the factors for which further runs of response steepest improvement become ineffective and a new initial experiment must be carried out.


Author(s):  
Muhammad Faheem Mushtaq ◽  
Urooj Akram ◽  
Muhammad Aamir ◽  
Haseeb Ali ◽  
Muhammad Zulqarnain

It is important to predict a time series because many problems that are related to prediction such as health prediction problem, climate change prediction problem and weather prediction problem include a time component. To solve the time series prediction problem various techniques have been developed over many years to enhance the accuracy of forecasting. This paper presents a review of the prediction of physical time series applications using the neural network models. Neural Networks (NN) have appeared as an effective tool for forecasting of time series.  Moreover, to resolve the problems related to time series data, there is a need of network with single layer trainable weights that is Higher Order Neural Network (HONN) which can perform nonlinearity mapping of input-output. So, the developers are focusing on HONN that has been recently considered to develop the input representation spaces broadly. The HONN model has the ability of functional mapping which determined through some time series problems and it shows the more benefits as compared to conventional Artificial Neural Networks (ANN). The goal of this research is to present the reader awareness about HONN for physical time series prediction, to highlight some benefits and challenges using HONN.


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