EFFECT OF HINGELESS ROTOR AEROELASTICITY ON HELICOPTER TRIM AND LONGITUDINAL STABILITY USING QUASILINEARIZATION

Abstract Cognitive dysfunction is a core feature of schizophrenia. The subtyping of cognitive performance in schizophrenia may aid the refinement of disease heterogeneity. The literature on cognitive subtyping in schizophrenia, however, is limited by variable methodologies and neuropsychological tasks, lack of validation, and paucity of studies examining longitudinal stability of profiles. It is also unclear if cognitive profiles represent a single linear severity continuum or unique cognitive subtypes. Cognitive performance measured with the Brief Assessment of Cognition in Schizophrenia was analyzed in schizophrenia patients (n = 767). Healthy controls (n = 1012) were included as reference group. Latent profile analysis was performed in a schizophrenia discovery cohort (n = 659) and replicated in an independent cohort (n = 108). Longitudinal stability of cognitive profiles was evaluated with latent transition analysis in a 10-week follow-up cohort. Confirmatory factor analysis (CFA) was carried out to investigate if cognitive profiles represent a unidimensional structure. A 4-profile solution was obtained from the discovery cohort and replicated in an independent cohort. It comprised of a “less-impaired” cognitive subtype, 2 subtypes with “intermediate cognitive impairment” differentiated by executive function performance, and a “globally impaired” cognitive subtype. This solution showed relative stability across time. CFA revealed that cognitive profiles are better explained by distinct meaningful profiles than a severity linear continuum. Associations between profiles and negative symptoms were observed. The subtyping of schizophrenia patients based on cognitive performance and its associations with symptomatology may aid phenotype refinement, mapping of specific biological mechanisms, and tailored clinical treatments.

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An Electrical Device for Solving the Equations of Longitudinal Stability

Journal of the Aeronautical Sciences (Institute of the Aeronautical Sciences) ◽

10.2514/8.173 ◽

1936 ◽

Vol 3 (5) ◽

pp. 158-160 ◽

Cited By ~ 2

Author(s):

R. K. MUELLER

Keyword(s):

Longitudinal Stability ◽

Electrical Device

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Behaviour disturbance and mental handicap: typology and longitudinal trends

Psychological Medicine ◽

10.1017/s0033291700019887 ◽

1984 ◽

Vol 14 (4) ◽

pp. 923-935 ◽

Cited By ~ 37

Author(s):

Ivan Leudar ◽

W. I. Fraser ◽

M. A. Jeeves

Keyword(s):

Longitudinal Study ◽

Mood Disturbance ◽

Behavioural Disturbance ◽

Mentally Handicapped ◽

Longitudinal Stability ◽

Mental Handicap ◽

Self Injury ◽

Long Term Changes ◽

Antisocial Conduct

SynopsisBehaviour disturbance was investigated in mentally handicapped adults who were living in hospital or at home. The first part of the study describes an empirically derived typology of disturbed behaviour patterns and gives the details of a scale by means of which behaviour disturbance can be quantified along six dimensions: aggression, mood disturbance, communicativeness, antisocial conduct, idiosyncratic mannerisms, and self-injury. The second part of the study used the scale in a longitudinal study of behavioural disturbance. Different forms of disturbed behaviour exhibited different kinds of longitudinal stability, and the long-term changes in one aspect of disturbance depended on subjects' other disturbance scores.

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