A nonlinear programming algorithm for the automated design and optimization of flexible space vehicle autopilots

1973 ◽  
Author(s):  
F. HAUSER
Keyword(s):  
Nonlinear Programming ◽  
Space Vehicle ◽  
Automated Design ◽  
Programming Algorithm ◽  
Design And Optimization

A Nonlinear Programming Algorithm for Optimizing Conventional Beamformer Shading Weights

2003 ◽  
Author(s):  
Thomas A. Wettergren ◽  
John P. Casey ◽  
Charles M. Traweek
Keyword(s):  
Nonlinear Programming ◽  
Programming Algorithm

scholarly journals Toeholder: a software for automated design and in silico validation of toehold riboswitches

2021 ◽  
Author(s):  
Angel Fernando Cisneros Caballero ◽  
Francois D. Rouleau ◽  
Carla Bautista ◽  
Pascale Lemieux ◽  
Nathan Dumont-Leblond
Keyword(s):  
In Silico ◽  
Dynamic Range ◽  
Regulatory Elements ◽  
Automated Design ◽  
Design And Optimization ◽  
Potential Applications ◽  
Dynamics Simulations ◽  
Effective Use ◽  
Biological Circuits ◽  
High Throughput Experiments

Synthetic biology aims to engineer biological circuits, which often involve gene expression. A particularly promising group of regulatory elements are riboswitches because of their versatility with respect to their targets, but early synthetic designs were not as attractive because of a reduced dynamic range with respect to protein regulators. Only recently, the creation of toehold switches helped overcome this obstacle by also providing an unprecedented degree of orthogonality. However, a lack of automated design and optimization tools prevents the widespread and effective use of toehold switches in high-throughput experiments. To address this, we developed Toeholder, a comprehensive open-source software for toehold design and in silico benchmarking. Toeholder takes into consideration sequence constraints as well as data derived from molecular dynamics simulations of a toehold switch. We describe the software and its in silico validation results, as well as its potential applications and impacts on the management and design of toehold switches.

Automated Design Tool for Automotive Control Actuators

2020 ◽  
Author(s):  
Cyril Picard ◽  
Jürg Schiffmann
Keyword(s):  
Automotive Industry ◽  
State Of The Art ◽  
Automated Design ◽  
Design Tool ◽  
System Level ◽  
Laptop Computer ◽  
Automotive Control ◽  
Design And Optimization ◽  
Reporting Tool ◽  
The Impact

Abstract Automated design tools are seldom used in industry. Their potential, however, is high, especially in companies mostly active in variant design, where custom tools could help cut down development time in the early stages. The design of geared electro-mechanical actuators for the automotive industry is such a case. These actuators are simple examples of coupled multi-disciplinary systems that can be hard to design, since they need to follow strict specifications in terms of performance and packaging. This paper presents an automated design and optimization tool tailored for such systems based on an integrated modeling approach, multi-objective optimization and an interactive reporting tool. The focus is set on the impact of system-level constraints on the usability by industry of the generated designs. In two case studies, the tool is able to find competitive actuator candidates that are cheaper (−3.6% and −11%) and more compact than similar existing products in less than an hour on a state-of-the-art laptop computer. More powerful options or actuators using different technologies have also been proposed. Compared to optimizations done without system-level constraints, the generated actuators are immediately usable by engineers to get accurate insights into the design problem and promote informed decision-making.

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