Characterization of Rocket-Plume Fluid-Dynamic Environment Using Numerical and Experimental Approaches

2013 ◽  
Vol 50 (3) ◽  
pp. 527-539 ◽  
Author(s):  
David R. González ◽  
Paul Wallman ◽  
Matthew Sanford ◽  
Jeremy Monat ◽  
Joel Carney
Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2467
Author(s):  
Chiara Vitale ◽  
Arianna Fedi ◽  
Alessandra Marrella ◽  
Gabriele Varani ◽  
Marco Fato ◽  
...  

Metastasis is a dynamic process involving the dissemination of circulating tumor cells (CTCs) through blood flow to distant tissues within the body. Nevertheless, the development of an in vitro platform that dissects the crucial steps of metastatic cascade still remains a challenge. We here developed an in vitro model of extravasation composed of (i) a single channel-based 3D cell laden hydrogel representative of the metastatic site, (ii) a circulation system recapitulating the bloodstream where CTCs can flow. Two polymers (i.e., fibrin and alginate) were tested and compared in terms of mechanical and biochemical proprieties. Computational fluid-dynamic (CFD) simulations were also performed to predict the fluid dynamics within the polymeric matrix and, consequently, the optimal culture conditions. Next, once the platform was validated through perfusion tests by fluidically connecting the hydrogels with the external circuit, highly metastatic breast cancer cells (MDA-MB-231) were injected and exposed to physiological wall shear stress (WSS) conditions (5 Dyn/cm2) to assess their migration toward the hydrogel. Results indicated that CTCs arrested and colonized the polymeric matrix, showing that this platform can be an effective fluidic system to model the first steps occurring during the metastatic cascade as well as a potential tool to in vitro elucidate the contribution of hemodynamics on cancer dissemination to a secondary site.


2003 ◽  
Vol 203-204 ◽  
pp. 590-595 ◽  
Author(s):  
F Toujou ◽  
K Tsukamoto ◽  
K Matsuoka

Materials ◽  
2019 ◽  
Vol 12 (17) ◽  
pp. 2762 ◽  
Author(s):  
Ruimin Shi ◽  
Bukang Wang ◽  
Zhiwei Yan ◽  
Zongyan Wang ◽  
Lei Dong

In order to explore the relationship between the surface topography parameters and friction properties of a rough contact interface under fluid dynamic pressure lubrication conditions, friction experiments were carried out. The three-dimensional surface topography of specimens was measured and characterized with a profile microscopy measuring system and scanning electron microscope. The friction coefficient showed a trend of decreasing first and then increasing with the increase in some surface topography parameters at lower pressure, such as the surface height arithmetic mean Sa, surface height distribution kurtosis Sku, surface volume average volume Vvv, and surface center area average void volume Vvc, which are the ISO 25178 international standard parameters. The effects of surface topographic parameters on friction were analyzed and the wear mechanism of the worn surface was presented. The wear characteristics of the samples were mainly characterized as strain fatigue, grinding, and scraping. The results provide a theoretical basis for the functional characterization of surface topography.


AIChE Journal ◽  
2017 ◽  
Vol 63 (9) ◽  
pp. 4177-4187 ◽  
Author(s):  
Douglas T. J. Marsh ◽  
Gary J. Lye ◽  
Martina Micheletti ◽  
Akinlolu O. O. Odeleye ◽  
Andrea Ducci ◽  
...  

Author(s):  
M. Cadorin ◽  
M. Pinelli ◽  
E. Podeschi ◽  
F. Pompoli ◽  
A. Zanardi

In recent years, the aerodynamic noise generated by centrifugal fans is receiving increasing attention because of strict environmental noise level restrictions and customer demands. The noise generated by fans is due to aerodynamic sources and to other several sources, such as, for instance, by the fan drive, by bearings and gearing, and, when present, by the inverter. Additional noise sources can be also due to structural resonance effects induced by periodic forces associated with the blade passing frequency or vortex shedding. Usually, these additional noise sources are dominated by aerodynamic noise generated by the fan, in particular when the intake and outlet of the fan are free. On the other side, if fan intake and outlet are ducted, the additional sources can relevantly contribute to overall sound generation. In this paper, an experimental characterization of the noise generated by industrial centrifugal fans when both inlet and outlet are ducted is presented. To do this, an experimental facility has been design and set up, and the sound power measured by means of the procedures outlined in the ISO 3746 international standard. A number of different type of centrifugal fan (straight-, forward- and backward blade) in different working conditions were tested, resulting in 133 different runs. These amount of data were then processed and a general formula for fan noise estimation obtained as a function of the geometrical and fluid dynamic parameters is derived. Moreover, specific coefficients with respect to blade geometry for the determination of the A-weighted frequency spectrum are presented. Finally, auxiliary devices or other features, such as inverter, thickness of the casing, acoustic insulation, electric motor shaft, are analyzed and some general rules to estimate their influence on sound power level quantified.


Author(s):  
Pallepati Vasavi ◽  
G Raja Ramesh

As per need of recent applications, new research aspects related to scalability, heterogeneity, and power consumption have been arisen. These problems are supposed to be fixed for better utilization of MANETs. MANET nodes interact through multi-hop routing. AODV is a commonly used on-demand protocol for routing in MANETs. In the existing literature, AODV has been analyzed a number of times but heterogeneity of the nodes has not been addressed. Heterogeneity may be defined as diversity among the nodes in resources or capability. The environment is usually heterogeneous in case of constraint fluid dynamic environment of MANET. In this paper we are analyzing the routing performance as well as energy efficient behavior of AODV routing protocol in both homogeneous and heterogeneous MANETs (H-MANETs), using performance parameters like ratio of delivered packets, throughput, average delay, average power consumption, energy of alive nodes, etc. Heterogeneity has been introduced in terms of different initial energy for all the nodes, unlike the homogeneous scenario. The simulation work has been done using network simulator (NS-2). This work will be helpful to get insight of effects of heterogeneity on energy efficiency and other performance metrics of AODV.


2021 ◽  
Vol 1977 (1) ◽  
pp. 012007
Author(s):  
Paolo Candeloro ◽  
Ranieri Emanuele Nargi ◽  
Edoardo Grande ◽  
Daniele Ragni ◽  
Tiziano Pagliaroli

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