scholarly journals Thyroid dysfunction in Congolese subjects with Down syndrome

2020 ◽  
Vol 2 (1) ◽  
pp. 38-43
Author(s):  
Toni Kasole Lubala ◽  
◽  
Olivier Mukuku ◽  
Tony Kayembe-Kitenge ◽  
Prosper Muenze Kayamba Kalenga ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Thyroid Dysfunction

scholarly journals Changes in the peripheral blood cell count in pediatric patients with Down syndrome

2019 ◽  
Vol 47 (8) ◽  
pp. 3757-3762
Author(s):  
Niculina Mang ◽  
Anda C. Vizitiu ◽  
Andrei Anghel
Keyword(s):  
Down Syndrome ◽  
Blood Cell ◽  
Cell Count ◽  
Peripheral Blood ◽  
Thyroid Dysfunction ◽  
Blood Count ◽  
Pediatric Patients ◽  
Complete Blood Count ◽  
Peripheral Blood Cell ◽  
Blood Cell Count

Objectives Down syndrome (DS) is associated with multiple complications, including a high risk of leukemia and thyroid dysfunction. This clinical study aimed to examine the complete blood cell count in patients with DS without leukemia or transient abnormal myelopoiesis. We also aimed to evaluate the effect of thyroid dysfunction on hematological anomalies in DS. Methods We analyzed the peripheral blood cell count in 23 pediatric patients with DS with and without thyroid dysfunction and in 17 pediatric patients without DS with thyroid dysfunction. Results Patients with DS showed greater neutrophilia and lymphopenia than did patients with DS and hypothyroidism and patients with hypothyroidism. Surprisingly, patients with DS showed a significant degree of eosinopenia in the peripheral blood. Interestingly, hypothyroidism had an attenuating effect on different lineages in the complete blood count. However, these anomalies were specific for DS. Conclusions Our clinical findings support previous data on DS-associated changes in the complete blood count. Our study also shows novel alterations in the complete blood count in leukemia-free patients with DS in association with hypothyroidism. The attenuating effect of thyroid dysfunction on changes in different lineages in the context of DS is novel and deserves further analysis in larger studies.

Relationship of autoimmunity to thyroid dysfunction in children and adults with Down syndrome

2005 ◽  
Vol 37 (S7) ◽  
pp. 238-241 ◽  
Author(s):  
Roberto T. Zori ◽  
Desmond A. Schatz ◽  
Harry Ostrer ◽  
Charles A. Williams ◽  
Rebecca Spillar ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Thyroid Dysfunction ◽  
Relationship Of

scholarly journals Aging and Down Syndrome: Implications for Physical Therapy

2007 ◽  
Vol 87 (10) ◽  
pp. 1399-1406 ◽  
Author(s):  
Robert C Barnhart ◽  
Barbara Connolly
Keyword(s):  
Down Syndrome ◽  
Thyroid Dysfunction ◽  
Developmental Delays ◽  
Activity Limitations ◽  
Healthy Life ◽  
Body Function ◽  
Structure Changes ◽  
Participation Restrictions ◽  
The Common

The number of people over the age of 60 years with lifelong developmental delays is predicted to double by 2030. Down syndrome (DS) is the most frequent chromosomal cause of developmental delays. As the life expectancy of people with DS increases, changes in body function and structure secondary to aging have the potential to lead to activity limitations and participation restrictions for this population. The purpose of this update is to: (1) provide an overview of the common body function and structure changes that occur in adults with DS as they age (thyroid dysfunction, cardiovascular disorders, obesity, musculoskeletal disorders, Alzheimer disease, depression) and (2) apply current research on exercise to the prevention of activity limitations and participation restrictions. As individuals with DS age, a shift in emphasis from disability prevention to the prevention of conditions that lead to activity and participation limitations must occur. Exercise programs appear to have potential to positively affect the overall health of adults with DS, thereby increasing the quality of life and years of healthy life for these individuals.

scholarly journals Studies on thyroid and hypophysary thyrotrophic hormone (TSH) in Down syndrome

1977 ◽  
Vol 35 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Benjamin J. Schmidt ◽  
Nelson Carvalho ◽  
Stanislau Krynski ◽  
Cláudio C. Ortega ◽  
José Liberman ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Thyroid Dysfunction ◽  
Clearance Rates ◽  
Radioiodine Uptake ◽  
Children With Down Syndrome ◽  
Normal Limits ◽  
Thyrotrophic Hormone ◽  
Thyroid Uptake ◽  
Before And After ◽  
Serum Tsh

Serum TSH was studied in 22 patients with Down syndrome, from 4 to 15 years old. In 6 of these patients radioiodine uptake by thyroid gland after 2 and 24 hours of administration and clearance rates before and after TSH stimulus (10 µl-IM) were measured. Results show that serum TSH was normal in 17 patients and above normal limits in 5 patients. Thyroid uptake after 2 hours as well clearance rates, both below normal, had a response to TSH stimulus with normal or below values. These data along with previous reports, suggest, that in children with Down syndrome, there is a thyroid dysfunction in which a slow response no TSH stimulus seems to be the basic defect.

scholarly journals Thyroid Function in Children with Down Syndrome in the Polish Population: A Case–Control Study

2020 ◽  
Vol 23 (6) ◽  
pp. 386-390
Author(s):  
Beata Zelazowska-Rutkowska ◽  
Anna Jakubiuk-Tomaszuk ◽  
Bogdan Cylwik
Keyword(s):  
Down Syndrome ◽  
Thyroid Function ◽  
Subclinical Hypothyroidism ◽  
Thyroid Disease ◽  
Thyroid Dysfunction ◽  
Clinical Symptoms ◽  
Control Group ◽  
Healthy Population ◽  
Polish Population ◽  
Children With Down Syndrome

Background: Patients with subclinical thyroid disease have few or no clinical symptoms of thyroid dysfunction and thus, laboratory diagnosis is needed. In this context, the objective of the current study was to analyze the prevalence rate and pattern of thyroid function in children with Down syndrome in the Polish population. Methods: A total of 30 children, aged 6–12 years, with cytogenetically confirmed Down syndrome were studied. The control group included 27 children. Results: Of the 30 patients with Down syndrome, 14 (46.7%) had abnormal thyroid profiles. Mean thyroid-stimulating hormone (TSH) and fT4 concentrations in children with Down syndrome were found to be significantly increased compared with the controls (4.30 ± 1.9 µIU/mL, 95% CI: 3.55–5.04 µIU/mL vs. 3.10 ± 1.47 µIU/mL, 95% CI: 2.52–3.68 µIU/mL, P = 0.013, 95% CI: 0.26–2.14, and 1.33 ± 0.23 ng/dL, 95% CI: 1.25–1.42 vs. 1.19 ± 0.14 ng/dL, 95% CI: 1.13–1.25, P = 0.008, 95% CI: 0.04–0.24, respectively). In Down syndrome, subclinical hypothyroidism was recognized in 10 children (33.3%) (high TSH and normal fT4 and fT3 levels). Two children (6.67%) had evident hypothyroidism (high TSH and low fT4). In the control group, subclinical hypothyroidism was diagnosed in four (14.8%) children. Conclusion: Children with Down syndrome may have increased secretion of TSH, even when thyroid hormone and autoantibodies are normal, suggesting that an isolated increase in TSH does not predispose the patient to the development of thyroid disease. We also recommend that all patients with Down syndrome should be screened for thyroid dysgenesis, since they have thyroid dysfunction more frequently as compared to the general healthy population.

scholarly journals Thyroid Dysfunction and Its Influence in Growth Velocity in Children with Down Syndrome: A Retrospective Study

2018 ◽  
Vol 22 (1) ◽  
pp. 6-9
Author(s):  
Vidhya Vishwanathan ◽  
Subramanian Sethuraman ◽  
Shanthi Balaji ◽  
VS Kalai Selvi ◽  
AJ Manjula Devi
Keyword(s):  
Down Syndrome ◽  
Retrospective Study ◽  
Growth Velocity ◽  
Thyroid Dysfunction ◽  
Children With Down Syndrome

scholarly journals Clinical Profiles, Congenital Heart Disease, and Other Comorbidities Among Egyptian Children with Down Syndrome: A Tertiary Center Study

2021 ◽  
Vol 11 (01) ◽  
pp. e233-e239
Author(s):  
Radwa Ezzat Amin ◽  
Iman Ehsan Abdel-Meguid ◽  
Nihal Mohamed El-Refaie ◽  
Walaa Fakher ◽  
Dina El-Tabie ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Down Syndrome ◽  
Heart Disease ◽  
Developmental Delay ◽  
Congenital Heart ◽  
Thyroid Dysfunction ◽  
Septal Defect ◽  
Dysmorphic Features ◽  
Tertiary Center ◽  
Clinical Profiles

Abstract Introduction Down syndrome (DS) is the most common chromosomal disorder. It is accompanied by several comorbidities, which could lead to severe morbidity and mortality. Congenital heart disease (CHD) is one of the most commonly described condition. Objective This study aimed to determine clinical profiles, dysmorphic features, CHD, and DS associated comorbidities in a tertiary center (Cairo, Egypt). Patients and Methods This descriptive study included 290 patients diagnosed with DS, who presented to the Clinical Genetics clinic, Cairo University Children Hospitals, from February 2018 to December 2019. The patients' ages ranged from 2 to 4 years old. All patients were evaluated by full history, clinical examination, anthropometric measurements, and assessment of developmental milestones. Patients' diagnostic investigations including karyotype, thyroid function, and echocardiography were checked. Results The study population consisted of 290 children with DS of which 196 (67.6%) were male, 115 (40%) had CHD, the most prevalent atrial septal defect (ASD), patent ductus arteriosus (PDA), and ventricular septal defect (VSD) accounting for 10.7, 7.1, and 4.2%, respectively. Common dysmorphic features were upward slanting palpebral fissures (98.6%), hypertelorism (97.9%), and sandal gap (60.7%). Thyroid dysfunction was the second prevalent comorbidity, found in 35 patients (12.1%). Global developmental delay was reported affecting language (99%), motor (94.8%), and social (92.8%) domains. Conclusion The prevalence of CHD among children with DS was 40% with ASD, PDA, and VSD being the commonest. Thyroid dysfunction was the second most common comorbidity. The most prevalent dysmorphic features were upward slanting palpebral fissures, hypertelorism, and sandal gap. Developmental delay was very common, language being the most affected domain.

scholarly journals Antithyroid Antibodies and Thyroid Dysfunction in Saudi Children with Down Syndrome

1994 ◽  
Vol 14 (4) ◽  
pp. 283-285 ◽  
Author(s):  
Mohamed Ahmed Abdullah ◽  
Hussain Salman ◽  
Sulaiman Al-Habib ◽  
Abdulrahman Ghareeb ◽  
Ahmed Abanamy
Keyword(s):  
Down Syndrome ◽  
Thyroid Dysfunction ◽  
Children With Down Syndrome ◽  
Antithyroid Antibodies
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