scholarly journals Comparative studies on the physiology of exercise in work animals, with special reference to the steady state

1956 ◽  
Vol 27 (3) ◽  
pp. 223-229 ◽  
Author(s):  
SEIKAN OKAMOTO ◽  
TAKAO OTSUBO ◽  
KIYOHIKO OGAWA ◽  
KAZUO TASHIRO
Keyword(s):  
Steady State ◽  
Special Reference ◽  
Comparative Studies

THE PHARMACOLOGY OF THE RAUWOLFIA ALKALOIDS CHANDRINE AND SERPAKRINE

1960 ◽  
Vol 38 (1) ◽  
pp. 889-897
Author(s):  
A. K. Reynolds ◽  
H. J. Presutti ◽  
D. P. MacLeod
Keyword(s):  
Smooth Muscle ◽  
Special Reference ◽  
Comparative Studies ◽  
Hypotensive Activity ◽  
Pharmacological Properties ◽  
Root Extracts ◽  
Cardiovascular Actions ◽  
Per Se ◽  
Ganglionic Blocking ◽  
Depressor Action

The pharmacological properties of two new alkaloids of Rauwolfia serpentina have been studied with special reference to their cardiovascular actions. In several instances, comparative studies have been carried out with the clinically used alseroxylon fraction of R. serpentina. Chandrine and serpakrine do not profoundly influence the activity or behavior of intact animals unless administered in very large doses. They are completely devoid of the tranquilizing action that characterizes such bases as reserpine and rescinnamine. They do, however, exhibit marked hypotensive activity. The mechanism of this depressor action has not been clearly established. It is not seen in spinal animals, and there is no evidence of ganglionic blocking or peripheral adrenolytic action. The effects of chandrine or serpakrine per se on smooth muscle structures are not pronounced, but antiacetylcholine activity has been observed on these and other preparations. Their contribution to the actions of the clinically employed whole-root extracts is probably not very marked.

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