scholarly journals Canonical Wnt-Signaling Activity During the Athletic Heart Formation

2018 ◽  
Vol 2018 (3) ◽  
pp. 33-39
Author(s):  
L.I. BORTNICHUK ◽  
◽  
A.O. MYRONOVA ◽  
D.S. AVRAMETS ◽  
V.V. BALATSKYI ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Canonical Wnt Signaling ◽  
Heart Formation ◽  
Canonical Wnt ◽  
Signaling Activity

Study of the canonical Wnt signaling activity in animals of different ages in the conditions of embryonic cardiac-specific β-catenin ablation

2015 ◽  
Vol 49 (1) ◽  
pp. 6-11 ◽  
Author(s):  
O. L. Palchevska ◽  
V. V. Balatskii ◽  
A. O. Andrejeva ◽  
L. L. Macewicz ◽  
O. O. Piven ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Canonical Wnt Signaling ◽  
Different Ages ◽  
Canonical Wnt ◽  
Signaling Activity

scholarly journals Identification of Compound Heterozygous Variants in LRP4 Demonstrates That a Pathogenic Variant outside the Third β-Propeller Domain Can Cause Sclerosteosis

Genes ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 80
Author(s):  
Yentl Huybrechts ◽  
Eveline Boudin ◽  
Gretl Hendrickx ◽  
Ellen Steenackers ◽  
Neveen Hamdy ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Pathogenic Variant ◽  
Luciferase Reporter ◽  
Compound Heterozygous ◽  
Canonical Wnt Signaling ◽  
High Bone Mass ◽  
The Third ◽  
Compound Heterozygous Variants ◽  
Canonical Wnt ◽  
Signaling Activity

Sclerosteosis is a high bone mass disorder, caused by pathogenic variants in the genes encoding sclerostin or LRP4. Both proteins form a complex that strongly inhibits canonical WNT signaling activity, a pathway of major importance in bone formation. So far, all reported disease-causing variants are located in the third β-propeller domain of LRP4, which is essential for the interaction with sclerostin. Here, we report the identification of two compound heterozygous variants, a known p.Arg1170Gln and a novel p.Arg632His variant, in a patient with a sclerosteosis phenotype. Interestingly, the novel variant is located in the first β-propeller domain, which is known to be indispensable for the interaction with agrin. However, using luciferase reporter assays, we demonstrated that both the p.Arg1170Gln and the p.Arg632His variant in LRP4 reduced the inhibitory capacity of sclerostin on canonical WNT signaling activity. In conclusion, this study is the first to demonstrate that a pathogenic variant in the first β-propeller domain of LRP4 can contribute to the development of sclerosteosis, which broadens the mutational spectrum of the disorder.

scholarly journals Canonical Wnt signaling activity during synovial joint development

2009 ◽  
Vol 40 (4) ◽  
pp. 311-316 ◽  
Author(s):  
Takashi Yamagami ◽  
Andrei Molotkov ◽  
Chengji J. Zhou
Keyword(s):  
Wnt Signaling ◽  
Synovial Joint ◽  
Canonical Wnt Signaling ◽  
Joint Development ◽  
Canonical Wnt ◽  
Signaling Activity

scholarly journals Canonical Wnt Signaling Activity in Early Stages of Chick Lung Development

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e112388 ◽  
Author(s):  
Rute Silva Moura ◽  
Eduarda Carvalho-Correia ◽  
Paulo daMota ◽  
Jorge Correia-Pinto
Keyword(s):  
Wnt Signaling ◽  
Lung Development ◽  
Canonical Wnt Signaling ◽  
Early Stages ◽  
Canonical Wnt ◽  
Signaling Activity

scholarly journals Wnt11/Wnt5a interaction increases canonical Wnt signaling activity

2009 ◽  
Vol 331 (2) ◽  
pp. 476
Author(s):  
Sang-Wook Cha ◽  
Emmanuel Tadjuidje ◽  
James Wells ◽  
Christopher Mayhew ◽  
Janet Heasman
Keyword(s):  
Wnt Signaling ◽  
Canonical Wnt Signaling ◽  
Canonical Wnt ◽  
Signaling Activity
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