scholarly journals Transcriptional Induction of Regulatory Genes Madcam1, S1pr1, Cxcr4 and Ccr7 that Control Lymphocyte Recirculation and Homing in Terms of Experimental Gestational Diabetes Affects T-cells Distribution in Mesenteric Lymph Nodes in Offspring

2017 ◽  
Vol 2017 (1) ◽  
pp. 23-33
Author(s):  
T. PROZOROVA ◽  
◽  
A. KAMYSHNY ◽  
I. TOPOL ◽  
◽  
...  
Keyword(s):  
T Cells ◽  
Gestational Diabetes ◽  
Lymph Nodes ◽  
Regulatory Genes ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph ◽  
Lymphocyte Recirculation ◽  
Transcriptional Induction

scholarly journals Lactobacillus reuteri DSM 17938 differentially modulates effector memory T cells and Foxp3+ regulatory T cells in a mouse model of necrotizing enterocolitis

2014 ◽  
Vol 307 (2) ◽  
pp. G177-G186 ◽  
Author(s):  
Yuying Liu ◽  
Dat Q. Tran ◽  
Nicole Y. Fatheree ◽  
J. Marc Rhoads
Keyword(s):  
T Cells ◽  
Lymph Nodes ◽  
Necrotizing Enterocolitis ◽  
Lactobacillus Reuteri ◽  
Intestinal Inflammation ◽  
Treg Cells ◽  
T Cell Subsets ◽  
Effector Memory ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph

Necrotizing enterocolitis (NEC) is an inflammatory disease with evidence of increased production of proinflammatory cytokines in the intestinal mucosa. Lactobacillus reuteri DSM 17938 (LR17938) has been shown to have anti-inflammatory activities in an experimental model of NEC. Activated effector lymphocyte recruitment to sites of inflammation requires the sequential engagement of adhesion molecules such as CD44. The phenotype of CD44+CD45RBlo separates T effector/memory (Tem) cells from naive (CD44−CD45RBhi) cells. It is unknown whether these Tem cells participate in the inflammation associated with NEC and can be altered by LR17938. NEC was induced in 8- to 10-day-old C57BL/6J mice by gavage feeding with formula and exposure to hypoxia and cold stress for 4 days. Survival curves and histological scores were analyzed. Lymphocytes isolated from mesenteric lymph nodes and ileum were labeled for CD4, CD44, CD45RB, intracellular Foxp3, and Helios and subsequently analyzed by flow cytometry. LR17938 decreased mortality and the incidence and severity of NEC. The percentage of Tem cells in the ileum and mesenteric lymph nodes was increased in NEC but decreased by LR17938. Conversely, the percentage of CD4+Foxp3+ regulatory T (Treg) cells in the intestine decreased during NEC and was restored to normal by LR17938. The majority of the Treg cells preserved by LR17938 were Helios+ subsets, possibly of thymic origin. In conclusion, LR17938 may represent a useful treatment to prevent NEC. The mechanism of protection by LR17938 involves modulation of the balance between Tem and Treg cells. These T cell subsets might be potential biomarkers and therapeutic targets during intestinal inflammation.

scholarly journals Homeostatic Proliferation of Naive CD4+ T Cells in Mesenteric Lymph Nodes Generates Gut-Tropic Th17 Cells

2013 ◽  
Vol 190 (11) ◽  
pp. 5788-5798 ◽  
Author(s):  
Takeshi Kawabe ◽  
Shu-lan Sun ◽  
Tsuyoshi Fujita ◽  
Satoshi Yamaki ◽  
Atsuko Asao ◽  
...  
Keyword(s):  
T Cells ◽  
Lymph Nodes ◽  
Cd4 T Cells ◽  
Th17 Cells ◽  
Homeostatic Proliferation ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph

scholarly journals Expression of Regulatory T Cells in Jejunum, Colon, and Cervical and Mesenteric Lymph Nodes of Dogs Naturally Infected with Leishmania infantum

2014 ◽  
Vol 82 (9) ◽  
pp. 3704-3712 ◽  
Author(s):  
Maria M. Figueiredo ◽  
Beatriz Deoti ◽  
Izabela F. Amorim ◽  
Aldair J. W. Pinto ◽  
Andrea Moraes ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Lymph Nodes ◽  
Leishmania Infantum ◽  
Parasite Load ◽  
Mesenteric Lymph Nodes ◽  
Content Type ◽  
Mesenteric Lymph ◽  
Tnf Α ◽  
Ifn Γ

ABSTRACTUsing flow cytometry, we evaluated the frequencies of CD4+and CD8+T cells and Foxp3+regulatory T cells (Tregs) in mononuclear cells in the jejunum, colon, and cervical and mesenteric lymph nodes of dogs naturally infected withLeishmania infantumand in uninfected controls. All infected dogs showed chronic lymphadenitis and enteritis. Despite persistent parasite loads, no erosion or ulcers were evident in the epithelial mucosa. The colon harbored more parasites than the jejunum. Frequencies of total CD4+, total Foxp3, and CD4+Foxp3+cells were higher in the jejunum than in the colon. Despite negative enzyme-linked immunosorbent assay (ELISA) serum results for cytokines, levels of interleukin-10 (IL-10), gamma interferon (IFN-γ), transforming growth factor beta (TGF-β), and tumor necrosis factor alpha (TNF-α) were higher in the jejunum than in the colon for infected dogs. However, IL-4 levels were higher in the colon than in the jejunum for infected dogs. There was no observed correlation between clinical signs and histopathological changes or immunological and parasitological findings in the gastrointestinal tract (GIT) of canines with visceral leishmaniasis. However, distinct segments of the GIT presented different immunological and parasitological responses. The jejunum showed a lower parasite load, with increased frequencies and expression of CD4, Foxp3, and CD8 receptors and IL-10, TGF-β, IFN-γ, and TNF-α cytokines. The colon showed a higher parasite load, with increasing expression of IL-4.Leishmania infantuminfection increased expression of CD4, Foxp3, IL-10, TGF-β, IFN-γ, and TNF-α and reduced CD8 and IL-4 expression in both the jejunum and the colon.

scholarly journals Commensal microbiota drive proliferation of conventional and Foxp3+Regulatory CD4+T cells in mesenteric lymph nodes and Peyer's patches

2013 ◽  
Vol 3 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Sascha Cording ◽  
Diana Fleissner ◽  
Markus M. Heimesaat ◽  
Stefan Bereswill ◽  
Christoph Loddenkemper ◽  
...  
Keyword(s):  
T Cells ◽  
Lymph Nodes ◽  
Cd4 T Cells ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Mesenteric Lymph Nodes ◽  
Commensal Microbiota ◽  
Mesenteric Lymph

scholarly journals Dynamics of CD4+CD25+ T Cells in Spleens and Mesenteric Lymph Nodes of Mice Infected with Schistosoma japonicum

2006 ◽  
Vol 38 (5) ◽  
pp. 299-304 ◽  
Author(s):  
Xiao-Ping CAI ◽  
Hui ZHANG ◽  
Yong-Chen ZHANG ◽  
Yong WANG ◽  
Chuan SU ◽  
...  
Keyword(s):  
T Cells ◽  
Lymph Nodes ◽  
Schistosoma Japonicum ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph

scholarly journals P179 MESENTERIC LYMPH NODES PLAY AN IMPORTANT ROLE IN SUPPLYING CROHN LESIONS WITH ACTIVATED T-CELLS

2007 ◽  
Vol 1 (1) ◽  
pp. 49
Author(s):  
M. Eberhardson ◽  
M. Karlsson ◽  
P. Karlén ◽  
K. Lindberg ◽  
O. Broström ◽  
...  
Keyword(s):  
T Cells ◽  
Lymph Nodes ◽  
Mesenteric Lymph Nodes ◽  
Activated T Cells ◽  
Mesenteric Lymph

Saccharomyces boulardii Inhibits Inflammatory Bowel Disease by Trapping T Cells in Mesenteric Lymph Nodes

2006 ◽  
Vol 131 (6) ◽  
pp. 1812-1825 ◽  
Author(s):  
Guillaume Dalmasso ◽  
Françoise Cottrez ◽  
Véronique Imbert ◽  
Patricia Lagadec ◽  
Jean-François Peyron ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
T Cells ◽  
Lymph Nodes ◽  
Bowel Disease ◽  
Saccharomyces Boulardii ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph ◽  
Inflammatory Bowel
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