scholarly journals Іnfluence of Quercetin on Lipid Peroxidation and the Activity of Antioxidant Enzymes in Erythrocytes of Rats with Experimental Diabetes Mellitus Type 2

2016 ◽  
Vol 2016 (4) ◽  
pp. 32-40
Author(s):  
O. SNITINSKAYA ◽  
◽  
M. HOTSKO ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Peroxidation ◽  
Antioxidant Enzymes ◽  
Diabetes Mellitus Type 2 ◽  
Experimental Diabetes ◽  
Diabetes Mellitus Type ◽  
Experimental Diabetes Mellitus

Lipid peroxidation and antioxidant system in patients with acute мyocardial infarction and diabetes mellitus type 2

2015 ◽  
Vol 9 (4) ◽  
pp. 0-0
Author(s):  
Загородняя ◽  
T. Zagorodnyaya ◽  
Корниенко ◽  
E. Kornienko ◽  
Иванов ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Myocardial Infarction ◽  
Lipid Peroxidation ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Antioxidant System ◽  
Diabetes Mellitus Type 2 ◽  
Coronary Intervention ◽  
Diabetes Mellitus Type

Problems of the treatment of comorbid patients in routine clinical practice remain highly relevant. One of the most common combinations – coronary heart disease and diabetes mellitus type 2. In this article, the authors present their own experience of studying the effects of infusion of the drug "Reamberin" at the stage of percutaneous coronary intervention on the dynamics of indicators of lipid peroxidation in patients with myocardial infarction with diabetes mellitus type 2. This study consists of the examination and treatment analysis of 54 patients, men aged 64,3 ± 6,8 years old with coronary heart disease and clinical manifestations of acute myocardial infarction and concomitant diabetes mellitus type 2. The percutaneous intervention was made of this group of patients. To determine the normal values of the studied parameters, the examination of 34 patients with coronary heart disease without exacerbation (men aged 62,5 ± 4,2 years) with concomitant diabetes mellitus type 2, was carried out. It is found that the development of acute myocardial infarction in patients with diabetes type 2 is accompanied by activation of processes of lipid peroxidation and antioxidant system of blood with a predominance of lipid peroxidation. It is proved that the use of succinic acid drug "Reamberin" at the stage of percutaneous coronary intervention in these patients contributes to the decrease in the intensity of free radical processes and increases the activity of enzymatic antioxidants.

scholarly journals Peroxisomal Enzymes in the Liver of Rats With Experimental Diabetes Mellitus Type 2

2014 ◽  
pp. S585-S591 ◽  
Author(s):  
L. TURECKÝ ◽  
V. KUPČOVÁ ◽  
E. UHLÍKOVÁ ◽  
V. MOJTO
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Diabetes Mellitus Type 2 ◽  
Experimental Diabetes ◽  
Beta Oxidation ◽  
Experimental Diabetes Mellitus

Diabetes mellitus is relatively frequently associated with fatty liver disease. Increased oxidative stress probably plays an important role in the development of this hepatopathy. One of possible sources of reactive oxygen species in liver is peroxisomal system. There are several reports about changes of peroxisomal enzymes in experimental diabetes, mainly enzymes of fatty acid oxidation. The aim of our study was to investigate the possible changes of activities of liver peroxisomal enzymes, other than enzymes of beta-oxidation, in experimental diabetes mellitus type 2. Biochemical changes in liver of experimental animals suggest the presence of liver steatosis. The changes of serum parameters in experimental group are similar to changes in serum of patients with non-alcoholic fatty liver disease. We have shown that diabetes mellitus influenced peroxisomal enzymes by the different way. Despite of well-known induction of peroxisomal beta-oxidation, the activities of catalase, aminoacid oxidase and NADH-cytochrome b5 reductase were not significantly changed and the activities of glycolate oxidase and NADP-isocitrate dehydrogenase were significantly decreased. The effect of diabetes on liver peroxisomes is probably due to the increased supply of fatty acids to liver in diabetic state and also due to increased oxidative stress. The changes of metabolic activity of peroxisomal compartment may participate on the development of diabetic hepatopathy.

Bone quality in diabetes mellitus type 2

2014 ◽  
Author(s):  
Peter Jackuliak ◽  
Zdenko Killinger ◽  
Juraj Payer
Keyword(s):  
Diabetes Mellitus ◽  
Bone Quality ◽  
Diabetes Mellitus Type 2 ◽  
Diabetes Mellitus Type
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