Use of ultraselective derivate of clonidine for prolonged sedation in term newborns with hypoxic-ischemic encephalopathy

2019 ◽  
Vol 25 (4) ◽  
pp. 4-10
Author(s):  
D.M. Surkov ◽  
Keyword(s):  
Hypoxic Ischemic Encephalopathy ◽  
Prolonged Sedation ◽  
Term Newborns ◽  
Ischemic Encephalopathy

A combined a-EEG and MR spectroscopy study in term newborns with hypoxic–ischemic encephalopathy

2010 ◽  
Vol 32 (10) ◽  
pp. 835-842 ◽  
Author(s):  
Gina Ancora ◽  
Silvia Soffritti ◽  
Raffaele Lodi ◽  
Caterina Tonon ◽  
Sara Grandi ◽  
...  
Keyword(s):  
Mr Spectroscopy ◽  
Hypoxic Ischemic Encephalopathy ◽  
Spectroscopy Study ◽  
Term Newborns ◽  
Ischemic Encephalopathy

scholarly journals Role of Matrix Metalloproteinase-9 in Neonatal Hypoxic-Ischemic Encephalopathy

2019 ◽  
Vol 7 (13) ◽  
pp. 2114-2118
Author(s):  
Mohab M. Salah ◽  
MA Abdelmawla ◽  
Sally R. Eid ◽  
Rasha mahmoud Hasanin ◽  
Eman A. Mostafa ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Hypoxic Ischemic Encephalopathy ◽  
Neonatal Encephalopathy ◽  
Central Nervous System Dysfunction ◽  
Brain Barrier Permeability ◽  
Term Newborns ◽  
Neurological Sequel ◽  
Metalloproteinase 9 ◽  
Ischemic Encephalopathy

BACKGROUND: Neonatal encephalopathy is a heterogeneous syndrome characterised by signs of central nervous system dysfunction in the newborn. Matrix metalloproteinase-9(MMP-9) increases the blood-brain barrier permeability, and their inhibitors can reduce its damage. MMP-9 has been implicated specifically in cerebral ischemia. AIM: To measure serum MMP-9 in neonatal hypoxic-ischemic encephalopathy and evaluate its correlation to the severity of early prediction and treatment. METHODS: its case-control study. The serum concentration of MMP-9 was determined by ELISA in 100 hypoxic neonates and 50 healthy neonates of matched age and sex who served as controls. RESULTS: In our present study the serum MMP-9 level was significantly higher at p = 0.0001 in hypoxic-ischemic full-term newborns (176.7 ± 68.7 ng/ml)as compared to control newborn (69.4 ± 34.85 ng/ml)and it was significantly higher at p = 0.0075 in hypoxic-ischemic preterm newborn (171.2 ± 132.9 ng/ml) when compared to control newborn (72.54 ± 36.74 ng/ml),also MMP-9 was significantly higher at Sarnat stage III at p = 0.0001. CONCLUSION: Serum MMP-9 level was significantly higher in hypoxic-ischemic newborns, and significantly increased with severity, so we suggest that serum MMP-9 level is important for predicting neurological sequel and severity in neonatal encephalopathy.  

Early Prediction of the Development of Microcephaly After Hypoxic-Ischemic Encephalopathy in the Full-term Newborn

PEDIATRICS ◽  
1996 ◽  
Vol 97 (1) ◽  
pp. 151-152
Author(s):  
Nadia Badawi ◽  
Jennifer J. Kurinczuk ◽  
Eve Blair ◽  
John Keogh ◽  
Fiona Stanley
Keyword(s):  
Full Term ◽  
Hypoxic Ischemic Encephalopathy ◽  
Early Prediction ◽  
Underlying Assumption ◽  
Term Newborn ◽  
Neurological Signs ◽  
Term Newborns ◽  
Ischemic Encephalopathy

We read with interest the article by Cordes et al.1 This article raises an important issue concerning assumptions made with respect to the significance of intrapartum and neonatal observations. The population of infants studied was 54 full-term newborns born after uneventful pregnancies and diagnosed as having acute hypoxic-ischemic encephalopathy (HIE) that was intrapartum in origin. The underlying assumption of this diagnosis was that if there is no obvious antenatal cause of abnormal neonatal neurological signs, then any suboptimal intrapartum observation identifies the pathology as being intrapartum in origin.

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