scholarly journals Clinicopathological Study of Prognostic Factors in Oral Squamous Cell Carcinoma

1997 ◽  
Vol 51 (5) ◽  
pp. 580-588
Author(s):  
Kenich Manabe
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clinicopathological Study

scholarly journals Oral squamous cell carcinoma: a clinicopathological study on 194 cases in northeastern Brazil. A cross-sectional retrospective study

2018 ◽  
Vol 136 (2) ◽  
pp. 165-169 ◽  
Author(s):  
Amanda Almeida Leite ◽  
Augusto César Leal da Silva Leonel ◽  
Jurema Freire Lisboa de Castro ◽  
Elaine Judite de Amorim Carvalho ◽  
Pablo Agustin Vargas ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Retrospective Study ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Northeastern Brazil ◽  
Cross Sectional ◽  
Clinicopathological Study

scholarly journals Prognostic Significance of PD-L1 and mTOR Expression in Oral Squamous Cell Carcinoma

2020 ◽  
Author(s):  
Nattinee Charoen ◽  
Kitti Jantharapattana ◽  
Paramee Thongsuksai
Keyword(s):  
Squamous Cell Carcinoma ◽  
Regression Analysis ◽  
Prognostic Factors ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cox Regression ◽  
Prognostic Significance ◽  
P Value ◽  
Cox Regression Analysis

Objective: Programmed cell death ligand 1 (PD-L1) and mammalian target of rapamycin (mTOR) are key players in host immune evasion and oncogenic activation, respectively. Evidence of the prognostic role in oral squamous cell carcinoma (OSCC) is conflicting. This study examined the associations of PD-L1 and mTOR expression with 5-year overall survival in OSCC patients. Material and Methods: The expressions of PD-L1 and mTOR proteins were immunohistochemically evaluated on tissue microarrays of 191 patients with OSCC who were treated by surgery at Songklanagarind Hospital, Thailand from 2008 to 2011. Cox regression analysis was used to determine independent prognostic factors. Results: PD-L1 expression was observed in 14.1% of cases while mTOR expression was present in 74.3% of cases. Females were more likely to have tumors with PD-L1 (p-value=0.007) and mTOR expressions (p-value=0.003) than males. In addition, lower clinical stage and well differentiated tumor are more likely to have mTOR expression (p-value= 0.038 and p-value<0.001, respectively). Cox regression analysis showed that age, tumor stage, nodal stage, combined surgical treatment with radiation or chemoradiation therapy, surgical margin status, PD-L1 expression and mTOR expression are independent prognostic factors. High PD-L1 expression (hazard ratio (HR) 3.14, 95% confidence interval (CI), 1.26–7.79) and high mTOR expression (HR 1.69, 95% CI, 1.00–2.84) are strong predictors of poor outcome. Conclusion: A proportion of OSCC expressed PD-L1 and mTOR proteins. Expression of PD-L1 and mTOR proteins are strong prognostic factors of OSCC.

scholarly journals Clinicopathological Study of Neo-adjuvant Chemotherapy for Oral Squamous Cell Carcinoma

1997 ◽  
Vol 51 (6) ◽  
pp. 761-767
Author(s):  
Hideo Kurokawa ◽  
Keiko Miura ◽  
Yoshihiro Yamashita ◽  
Shingo Tokudome ◽  
Tomoyuki Murata ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Adjuvant Chemotherapy ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clinicopathological Study ◽  
Neo Adjuvant Chemotherapy

Prognostic factors and survival analysis in a sample of oral squamous cell carcinoma patients

2008 ◽  
Vol 106 (5) ◽  
pp. 685-695 ◽  
Author(s):  
Lucinei Roberto Oliveira ◽  
Alfredo Ribeiro-Silva ◽  
João Paulo Oliveira Costa ◽  
Aguinaldo Luiz Simões ◽  
Miguel Angel Sala Di Matteo ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Survival Analysis ◽  
Prognostic Factors ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell

scholarly journals pEGFR-Tyr 845 expression as prognostic factors in oral squamous cell carcinoma

2012 ◽  
Vol 13 (11) ◽  
pp. 967-977 ◽  
Author(s):  
Gabriella Aquino ◽  
Giuseppe Pannone ◽  
Angela Santoro ◽  
Giuseppina Liguori ◽  
Renato Franco ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell

Oral Squamous Cell Carcinoma: A Clinicopathological Study of 342 Thai Cases

2009 ◽  
Vol 10 (5) ◽  
pp. 33-41 ◽  
Author(s):  
Robert P. Langlais ◽  
Aree Jainkittivong ◽  
Somporn Swasdison ◽  
Malee Thangpisityotin
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Age At Diagnosis ◽  
Care Providers ◽  
Histological Grading ◽  
Female Ratio ◽  
Dental Practitioners ◽  
Clinicopathological Study

Abstract Aim To conduct a clinicopathological review of oral squamous cell carcinoma (SCC) and to analyze it with respect to gender, age at diagnosis, clinical presentation, lesion location, and histological grading. Methods and Materials Information on the clinicopathological characteristics of SCC was obtained from pathology reports of 342 cases. Results The male to female ratio was 1:1 and the incidence increased with age. Among the patients 4.7% were younger than 40 years and males were predominant in this subgroup. The alveolar ridge and gingiva were the most commonly affected sites (50%). The majority of the SCC cases presented as ulcers or masses. Swelling and/or pain were the first signs and/ or symptoms in most patients (52.6%). The age at diagnosis in relation to the site of occurrence varied. Conventional SCC was the most common subtype (88%). Well-differentiated SCC was the most common histological grading (78.6%). Conclusion In the present study, the incidence of SCC was age-related and showed equal gender distribution. Clinical Significance Routine examination of the oral cavity by dental practitioners and other health care providers aids in the early detection of premalignant and malignant oral disease. Dentists can play a significant role in disseminating information regarding oral cancer. Citation Jainkittivong A, Swasdison S, Thangpisityotin M, Lnaglais RP. Oral Squamous Cell Carcinoma: A Clinicopathological study of 342 Thai Cases. J Contemp Dent Pract [Internet]. 2009 Sept; 10(5). Available from: http://www.thejcdp. com/journal/view/oralsquamous-cell-carcinoma-aclinicopathological- study-of-342-thai-cases.

Independent prognostic factors of 861 cases of oral squamous cell carcinoma in Korean adults

Oral Oncology ◽  
2006 ◽  
Vol 42 (2) ◽  
pp. 208-217 ◽  
Author(s):  
Keum-Kang Choi ◽  
Myung-Jin Kim ◽  
Pil-Young Yun ◽  
Jong-Ho Lee ◽  
Hyock-Soo Moon ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Korean Adults
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