scholarly journals Soluble HLA-G Serum Levels Depend on Allergy Type and IgE Levels

2014 ◽  
Vol 5 (1) ◽  
pp. ar.2014.5.0076 ◽  
Author(s):  
Giorgio Ciprandi ◽  
Mara DeAmici
Keyword(s):  
Immune Response ◽  
Allergic Rhinitis ◽  
Allergic Reaction ◽  
Healthy Subjects ◽  
Serum Levels ◽  
Specific Ige ◽  
Immunomodulatory Activity ◽  
Immunoenzymatic Method ◽  
Soluble Hla ◽  
Normal Controls

Allergic rhinitis (AR) is characterized by Th2 polarized immune response. Soluble HLA (sHLA) molecules play an immunomodulatory activity. Two different studies evidenced that both patients with seasonal AR (SAR) and patients with perennial AR (PAR) had higher sHLA-G levels than normal controls. The aim of this study was to compare sHLA-G serum levels in SAR and PAR patients, also considering allergen-specific IgE. One hundred sixty-eight AR patients were enrolled, 94 with SAR and 74 with PAR. A group of 116 healthy subjects was considered as control. sHLA-G and allergen-specific IgE serum levels were determined by immunoenzymatic method. SAR patients had significantly higher levels of sHLA-G than PAR patients (p = 0.0194). sHLA-G was moderately related to allergen-specific IgE both in SAR (r = 0.497) and in PAR patients (r = 0.584). The present study provides evidence that sHLA-G serum levels depend on the type of allergy and are related to allergen-specific IgE serum levels. These findings may suggest that sHLA-G could be a biomarker of allergic reaction.

Serum-Soluble HLA-G Is Associated with Specific IgE in Patients with Allergic Rhinitis and Asthma

Inflammation ◽  
2014 ◽  
Vol 37 (5) ◽  
pp. 1630-1634 ◽  
Author(s):  
G. Ciprandi ◽  
A. Corsico ◽  
P. Pisati
Keyword(s):  
Allergic Rhinitis ◽  
Specific Ige ◽  
Soluble Hla

Evaluation of Dermatophagoides pteronyssinus (Trouessart) and D. farinae Hughes (Acari: Pyroglyphidae) sensitivity in patients with allergic rhinitis: a comparative study

2018 ◽  
Vol 23 (2) ◽  
pp. 206
Author(s):  
Erhan ZEYTUN ◽  
Salih DOĞAN ◽  
Edhem Ünver ◽  
Fatih ÖZÇÜÇEK
Keyword(s):  
Allergic Rhinitis ◽  
Comparative Study ◽  
Clinical Assessment ◽  
Serum Levels ◽  
Specific Ige ◽  
Dermatophagoides Pteronyssinus ◽  
Total Ige ◽  
Serologic Tests ◽  
Stereo Microscope ◽  
Skin Prick Tests

This study was conducted to determine the sensitivity to Dermatophagoides pteronyssinus (Trouessart) and D. farinae Hughes with skin prick tests (SPT) and serologic tests in patients with allergic rhinitis (AR), and to specifically search for those mites in homes of patients. A total of 51 participants, (23 patients and 28 controls) were utilized. Skin-prick tests with D. pteronyssinus and D. farinae allergens were performed on all participants, and serum levels of allergen-specific lgE and total IgE were also measured. Dust samples were collected from homes of all participants and examined under a stereo microscope. 977 D. pteronyssinus (mean 44.4/g) and 24 D. farinae (mean 4.0/g) were isolated from the homes of patients, whereas 35 D. pteronyssinus (mean 4.4/g), and four D. farinae (mean 2.0/g) were isolated from the homes of the controls. Patients with D. pteronyssinus in their homes had 95.5% sensitivity to the species according to SPT and 27.3 according to IgE. Patients with D. farinae in their homes had 83.3% sensitivity to the species according to SPT, and 50% according to IgE. Dermatophagoides pteronyssinus sensitivity in the controls was detected as 12.5% according to SPT; however, D. farinae sensitivity was not detected according to both SPT and mite-specific IgE. Differences between patients and controls utilizing SPT results was statistically significant, but not when using mite-specific IgE results. As a result, it was determined that patients with AR in Erzincan province were sensitized to D. pteronyssinus and D. farinae, and that their homes contained those species. It may be helpful to consider these findings in clinical assessment of patients with AR, and also in treatment utilizing immunotherapy techniques.

Sublingual immunotherapy reduces soluble HLA-G and HLA-A,-B,-C serum levels in patients with allergic rhinitis

2009 ◽  
Vol 9 (2) ◽  
pp. 253-257 ◽  
Author(s):  
Giorgio Ciprandi ◽  
Paola Contini ◽  
Angela Pistorio ◽  
Giuseppe Murdaca ◽  
Francesco Puppo
Keyword(s):  
Allergic Rhinitis ◽  
Sublingual Immunotherapy ◽  
Serum Levels ◽  
Soluble Hla

scholarly journals Serum levels of total IgE and soluble CD23 in bronchial asthma

1996 ◽  
Vol 5 (1) ◽  
pp. 43-46 ◽  
Author(s):  
G. Di Lorenzo ◽  
P. Mansueto ◽  
M. Melluso ◽  
G. Morici ◽  
D. Cigna ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Healthy Subjects ◽  
Serum Levels ◽  
Total Serum ◽  
Control Group ◽  
Bronchial Responsiveness ◽  
Total Ige ◽  
Soluble Cd23 ◽  
Asthmatic Patients ◽  
Normal Controls

The aim of the present study was to compare, during the pollen season, serum levels of total IgE and soluble CD23 (sCD23) from patients with allergic bronchial asthma, with those from healthy subjects. Significantly higher levels of total IgE and sCD23 were found in patients with asthma compared to the control group. Both in normal controls and in asthmatic patients, a significant correlation was shown between the levels of these two molecules. In asthmatic patients, significant correlations were found for both total IgE and sCD23, with lung function measured as bronchial responsiveness to inhaled methacholine. These results suggest that in asthmatic patients, in addition to the study of total serum IgE levels, the assessment of sCD23 serum levels may be helpful in the evaluation of disease activity.

scholarly journals The effect of Lactobacillus johnsonii Ncc533 (La1) on the balance of Th1/Th2 cells in BALB/c mice

2011 ◽  
Vol 34 (4) ◽  
pp. 254 ◽  
Author(s):  
Junli Yang ◽  
Wen Li ◽  
Ruopeng Sun ◽  
Baomin Li
Keyword(s):  
Flow Cytometry ◽  
Immune Response ◽  
Serum Levels ◽  
Treated Group ◽  
Specific Ige ◽  
Th2 Cells ◽  
Control Group ◽  
Lactobacillus Johnsonii ◽  
Asthma Model ◽  
Ifn Γ

Purpose: To determine the effect of Lactobacillus johnsonii Ncc533 (La1) on Th1/Th2 balance, the production of IL-4 and IFN-γ by splenocytes was evaluated following its administration to mice from newborn to adult. Changes in IL-4 and IFN-γ expression and serum levels of OVA-specific-IgE were then investigated in an asthma model. Methods: Using flow cytometry (FCM) and ELISA, the percentage of IL-4 and IFN-γ expressing splenocytes and serum levels of OVA-specific-IgE were measured in different groups of mice. Results: The percentages of IL-4 and IFN-γ expressing splenocytes in the offspring and in the adults of the La1-treated group were not significantly different when compared with the water-treated group. In the asthma model, the percentages of IL-4 expressing cells and the serum levels of OVA-specific-IgE in the La1-treated and water-treated group were significantly increased compared with those in the control group. The percentage of IFN-γ expressing cells was significantly lower in the La1-treated and water-treated groups. The percentage of IL-4 expressing cells and the serum levels of OVA-specific-IgE in the La1-treated group were significantly lower compared with those in the water-treated group, whereas the percentage of IFN-γ expressing cells was significantly higher. Conclusion: Administration of La1 had no effect on the immune system from the neonate to the adult in the normal mice. It did, however, significantly alter the percentages of IL-4 or IFN-γ expressing CD4+ T lymphocytes in the asthma model, suggesting that administration of La1 might regulate the immune response.

Relationship between soluble HLA-G and HLA-A,-B,-C serum levels, and interferon-γ production after sublingual immunotherapy in patients with allergic rhinitis

2008 ◽  
Vol 69 (7) ◽  
pp. 409-413 ◽  
Author(s):  
Giorgio Ciprandi ◽  
Paola Continia ◽  
Daniela Fenoglio ◽  
Maria Pia Sormani ◽  
Simone Negrini ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Sublingual Immunotherapy ◽  
Serum Levels ◽  
Interferon Γ ◽  
Soluble Hla

scholarly journals IL-10 AND IL-35 AS INFLAMMATION REGULATORS IN PATIENTS WITH ALLERGIC RHINITIS AND MILD ATOPIC ASTHMA

2022 ◽  
pp. 1-12
Keyword(s):  
Allergic Rhinitis ◽  
Healthy Subjects ◽  
Respiratory Diseases ◽  
Allergic Inflammation ◽  
Serum Levels ◽  
Airway Disease ◽  
Allergic Airway Disease ◽  
Atopic Asthma ◽  
Healthy State ◽  
Immunosuppressive Cytokines

Background. Significantly less is known about the immunoregulative cytokines, especially in allergic airway disease. This study aims to present the involvement of IL-35 and IL-10 in patients with allergic rhinitis (AR) and allergic bronchial asthma (BA). Methodology. The study comprised 71 patients –AR, patients with concomitant AR and mild atopic BA, and healthy controls (HC). We examined the serum levels of IL-35 and IL-10, along with other instrumental examinations, between March and September 2021. Findings. Levels of the regulatory cytokines IL-35 and IL-10 were significantly lower in patients than in HC (87.19±11.90 vs. 96.12±1.79 pg/ml; and 30.26±17.55 vs. 111.56±65.03 pg/ml, respectively). Furthermore, threefold higher serum IL-10 levels were found in healthy subjects compared to patients (p = 0.006). No difference in the levels of interleukins was found between the studied groups. Conclusions. Our results indicate that elevated IL-35 and IL-10 may play an essential role in reducing the activity of underlying allergic inflammation in allergic respiratory diseases, although no difference in the levels of the studied cytokines was found between the different groups of patients. Therefore, we can speculate that the immunosuppressive cytokines IL-35 and IL-10 were involved in maintaining the healthy state of no inflammation.

Soluble HLA-G and HLA-A,-B,-C serum levels in patients with allergic rhinitis

Allergy ◽  
2008 ◽  
Vol 63 (10) ◽  
pp. 1335-1338 ◽  
Author(s):  
G. Ciprandi ◽  
B. M. Colombo ◽  
P. Contini ◽  
P. Cagnati ◽  
A. Pistorio ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Serum Levels ◽  
Soluble Hla

scholarly journals Expressions of IL-17, IL-21 and IL-23 in the Serum of Allergic Rhinitis Patients

2011 ◽  
Vol 30 (4) ◽  
pp. 323-327 ◽  
Author(s):  
Xuekun Huang ◽  
Qintai Yang ◽  
Yulian Chen ◽  
Peng Li ◽  
Gehua Zhang ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Healthy Subjects ◽  
Serum Levels ◽  
Interleukin 17 ◽  
Serum Samples ◽  
Significant Difference ◽  
Quantitative Immunofluorescence ◽  
The Mean ◽  
Analysis System ◽  
Inhalant Allergens

Expressions of IL-17, IL-21 and IL-23 in the Serum of Allergic Rhinitis PatientsThe present study aimed to investigate the expressions of interleukin-17 (IL-17), IL-21 and IL-23 in the serum of allergic rhinitis (AR) patients and to explore their relationship with special IgE (sFgE) in the serum. AR patients (n=24) and healthy subjects (n=12) were recruited and serum samples were collected. The serum level of IgE specific for inhalant allergens was determined using the automatic quantitative immunofluorescence analysis system, and the contents of IL-17, IL-21 and IL-23 in the serum were detected using ELISA. The level of serum IgE in the healthy individuals was categorized as grade 0 and that in the AR patients as grade 2-6. The mean contents of IL-17, IL-21 and IL-23 were 164.71 ±39.37 pg/mL, 199±97.86 pg/mL and 78.94±26.33 pg/mL, respectively, in the AR patients, and 67.75±18.24 pg/mL, 7.58±5.49 pg/mL and 13.58± 3.93 pg/mL, respectively, in the healthy subjects. Statistical analysis showed the serum levels of IL-17 and IL-23 in the AR patients were markedly higher than those in the healthy subjects, however, no significant difference was noted in the content of IL-21. Furthermore, the IL-17 level was positively related to the levels of IL-23 and IgE and the IL-23 level was positively related to the IgE level among AR patients, but no relations were observed between the IL-21 level and levels of IL-17, IL-23 and IgE. Our study indicates IL-17 and IL-23 may play an important role in the pathogenesis of AR and maybe IL-21 is not involved in the occurrence of AR.

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