scholarly journals Expression of Bone Morphogenic Protein in Sinonasal Inverted Papilloma with New Bone Formation

2011 ◽  
Vol 2 (1) ◽  
pp. ar.2011.2.0004 ◽  
Author(s):  
Tomoyo Okamoto ◽  
Satoru Kodama ◽  
Nozomi Nomi ◽  
Shingo Umemoto ◽  
Masashi Suzuki
Keyword(s):  
Bone Formation ◽  
Complete Removal ◽  
Bone Morphogenic Protein ◽  
Inverted Papilloma ◽  
Sinus Surgery ◽  
New Bone Formation ◽  
Common Benign Tumor ◽  
Sinonasal Inverted Papilloma ◽  
Tumor Tissues

Inverted papilloma (IP) is a common benign tumor in the nose and sinus. Osteogenesis in sinonasal IP is extremely rare; to date, only five cases of IP with new bone formation appear in the literature. In addition, the mechanism of osteogenesis in IP remains unclear. Here, we describe three cases of IP with new bone formation and an investigation into a possible role for bone morphogenic protein (BMP) in osteogenesis. Of three patients with sinonasal IP with new bone formation, two were treated by endoscopic sinus surgery and one was followed up with watchful waiting. Tumor tissues were subjected to immunohistochemistry to detect BMP expression. The patients were successfully treated surgically and showed no evidence of recurrence postoperatively. Follow-up examination is ongoing. Immunohistochemically, the tumors expressed BMP-4 but not BMP-2 or BMP-7. ESS could be successfully used to achieve complete removal of the sinonasal IPs with new bone formation. BMP-4 might be associated with new bone formation in the tumor.

scholarly journals Sinonasal Schwannoma with New Bone Formation Expressing Bone Morphogenic Protein

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Satoru Kodama ◽  
Tomoyo Okamoto ◽  
Masashi Suzuki
Keyword(s):  
Bone Formation ◽  
Benign Tumor ◽  
Nerve Fibers ◽  
Bone Morphogenic Protein ◽  
The Body ◽  
Sinus Surgery ◽  
New Bone Formation ◽  
Myelinated Nerve ◽  
Bone Morphogenic Protein 4

Schwannoma is a benign tumor that arises from the sheath of myelinated nerve fibers and may occur in any part of the body. Osteogenesis in schwannoma is extremely rare and, to date, new bone formation in sinonasal schwannoma has not yet been reported. Here, we describe the first reported case of sinonasal schwannoma with new bone formation. The tumor was successfully treated by endoscopic sinus surgery, and the patient showed no evidence of recurrence 24 months postoperatively. Immunohistochemically, the tumor expressed bone morphogenic protein 4, indicating a possible role of this protein in the new bone formation in schwannomas.

Consistent New Bone Formation in 95 Revisions: Average 9-Year Follow-Up

Orthopedics ◽  
2008 ◽  
Vol 31 (7) ◽  
pp. 1-7 ◽  
Author(s):  
George Mantelos ◽  
Panagiotis Koulouvaris ◽  
Hlias Kotsovolos ◽  
Theodoros Xenakis
Keyword(s):  
Bone Formation ◽  
New Bone Formation

Clinical Implications of Carcinoma In Situ in Sinonasal Inverted Papilloma

2019 ◽  
Vol 161 (6) ◽  
pp. 1036-1042 ◽  
Author(s):  
Ivy W. Maina ◽  
Charles C. L. Tong ◽  
Esther Baranov ◽  
Neil N. Patel ◽  
Vasiliki Triantafillou ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Recurrence Rate ◽  
Carcinoma In Situ ◽  
Inverted Papilloma ◽  
Sinonasal Inverted Papilloma ◽  
Definitive Surgery ◽  
Severe Degree ◽  
Multiple Recurrences

Objective Sinonasal inverted papilloma (IP) is a typically benign sinonasal tumor with a tendency to recur and the potential for malignant transformation. Varying degrees of dysplasia may be present, of which carcinoma in situ (CIS) is most advanced. We hereby describe the biological and clinical behavior of IP with CIS (IPwCIS). Study Design Retrospective cohort. Setting Tertiary academic referral center. Subjects and Methods Patients who underwent surgical resection for IP between 2002 and 2017. Pertinent clinical data were obtained, and all IPwCIS cases were histologically confirmed. Results In total, 37 of 215 cases (17.2%) were identified with IPwCIS. Mean age was 57 years and 86.5% of patients were male. Median follow-up was 82 months, and the recurrence rate was 27%. The maxillary sinus was the most common primary site (37.8%) and 14 tumors (37.8%) demonstrated multifocal attachment, which was associated with recurrence (odds ratio [OR], 9.7; 95% confidence interval [CI], 1.4-112.8; P = .028). IPwCIS was also associated with multiple recurrences (OR, 2.71; 95% CI, 1.246-5.814; P = .021). Most patients were treated with surgery alone (89.1%) and 4 patients received adjuvant radiotherapy (8.1%). Only 1 patient (2.7%) demonstrated malignant transformation after definitive surgery. Conclusions IPwCIS represents the most severe degree of dysplasia prior to malignant transformation and is associated with higher recurrence rate and multifocal involvement but low rate of conversion to invasive carcinoma. The need for adjuvant therapy remains controversial, and further research into the etiology of the disease is warranted.

Inverted Papilloma with New Bone Formation in Ethmoidofrontal Region

2006 ◽  
Vol 134 (2) ◽  
pp. 343-344 ◽  
Author(s):  
Burhan Dadas ◽  
İbrahim Ercan ◽  
Tulay Başak
Keyword(s):  
Bone Formation ◽  
Inverted Papilloma ◽  
New Bone Formation

Post-operative roentgenological findings and changes after mastoid obliteration

1983 ◽  
Vol 97 (5) ◽  
pp. 393-398 ◽  
Author(s):  
Kauko Ojala ◽  
Reijo Lahti ◽  
Antti Palva ◽  
Martti Sorri
Keyword(s):  
Bone Formation ◽  
Frequent Occurrence ◽  
New Bone Formation ◽  
Mastoid Obliteration ◽  
X Ray ◽  
Radiological Features ◽  
Operative Complications ◽  
Post Operative Complications

AbstractThis study consisted of the evaluation of the plain X-ray findings of films taken at early follow-up (mean 1.5 months after surgery) and at late follow-up(4–14 years after the early films) of 211 ears which had been operated on radically and obliterated. Residual cells which were detected on the basis of the early films were associated with a more frequent occurrence of post-operative infection and were thus hallmarks of a poorer prognosis. Changes in the bone surrounding the surgical cavity and the radiological quality of the walls of the surgical cavity, the presence of new bone formation in the cavity and other radiological features did not yield useful information about post-operative complications. New bone formation was associated with a smaller amount of post-operative cavitation. Post-operative X-ray examination of the obliterated ear is a prognostically useful examination, but it does not significantly contribute further to the information available by clinical and otomicroscopic examination in regards to the complications of infection and cholesteatoma.

scholarly journals Monophasic Epithelial Synovial Sarcoma Accompanied by an Inverted Papilloma in the Sphenoid Sinus

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Xiaohua Jiang ◽  
Qi Huang ◽  
Jianguo Tang ◽  
Matthew R. Hoffman
Keyword(s):  
Synovial Sarcoma ◽  
Sphenoid Sinus ◽  
Inverted Papilloma ◽  
Sinus Surgery ◽  
Nasal Discharge ◽  
Olfactory Sensation ◽  
History Of ◽  
The Right ◽  
Sphenoid Sinuses

A 58-year-old man presented with a six-month history of intermittent blood-stained posterior nasal discharge. Five years ago, he had a three-week episode of fitful light headaches. Nasal ventilation, olfactory sensation, and facial sensation were normal; there were no ophthalmological complaints. Coronal computed tomography (CT) scans revealed soft masses in the bilateral sphenoid sinuses with bone absorption. The patient underwent bilateral functional endoscopic sinus surgery and resection of right nasal papillary masses. Papillary masses and mucosa in both sphenoid sinuses were also removed. The mass in the left sphenoid sinus was diagnosed as two separate entities, one being a primary monophasic epithelial synovial sarcoma and the other an inverted papilloma, while the mass in the right sphenoid sinus was an inverted papilloma. After surgery, the patient underwent radiotherapy and chemotherapy. At the 50-month follow-up visit, there were no signs of recurrence.

scholarly journals Safety of autologous bone marrow aspiration concentrate transplantation: initial experiences in 101 patients

2009 ◽  
Vol 1 (1) ◽  
pp. 32 ◽  
Author(s):  
Christian Hendrich ◽  
Franz Engelmaier ◽  
Gerhart Waertel ◽  
Rolf Krebs ◽  
Marcus Jäger
Keyword(s):  
Bone Marrow ◽  
Cell Therapy ◽  
Bone Formation ◽  
Ex Vivo ◽  
Bone Marrow Aspiration ◽  
Tumor Formation ◽  
Surveillance Study ◽  
New Bone Formation ◽  
Technical Effort

The clinical application of cellular based therapies with ex vivo cultivation for the treatment of diseases of the musculoskeletal system has until now been limited. In particular, the advanced laboratory and technical effort necessary, regulatory issues as well as high costs are major obstacles. On the other hand, newly developed cell therapy systems permit intra-operative enrichment and application of mesenchymal and progenitor stem cells from bone marrow aspirate concentrate (BMAC) in one single operative session. The objective of the present clinical surveillance study was to evaluate new bone formation after the application of BMAC as well as to record any possible therapy-specific complications For this purpose, the clinical-radiological progress of a total of 101 patients with various bone healing disturbances was documented (surveillance study). The study included 37 necrosis of the head of the femur, 32 avascular necroses/bone marrow edema of other localization, 12 non-unions, 20 other defects. The application of BMAC was performed in the presence of osteonecrosis via a local injection as part of a core decompression (n=72) or by the local adsorption of intra-operative cellular bone substitution material (scaffold) incubated with BMAC during osteosynthesis (n=17) or in further surgery (n=12). After an average of 14 months (2-24 months), the patients were re-examined clinically and radiologically and interviewed. Further surgery was necessary in 2 patients within the follow-up period. These were due to a progression of a collapsed head of the femur with initial necrosis in ARCO Stage III, as well as inadequate new bone formation with secondary loss of correction after periprosthetic femoral fracture. The latter healed after repeated osteosynthesis plus BMAC application without any consequences. Other than these 2 patients, no further complications were observed. In particular, no infections, no excessive new bone formation, no induction of tumor formation, as well as no morbidity due to the bone marrow aspiration from the iliac crest were seen. There were no specific complications within the short follow-up period and a simple intra-operative use of the system for different forms of bone loss could be demonstrated. In the authors’ opinion, the on-site preparation of the bone marrow cells within the operating theater eliminates the specific risk of ex vivo cell proliferation and has a safety advantage in the use of autologous cell therapy for bone regeneration. Additional studies should be completed to determine efficacy.

Primary temporal inverted papilloma with premalignant change

2010 ◽  
Vol 125 (2) ◽  
pp. 206-209 ◽  
Author(s):  
H Zhou ◽  
Z Chen ◽  
H Li ◽  
G Xing
Keyword(s):  
Recurrence Rate ◽  
Radical Resection ◽  
Therapeutic Strategies ◽  
Inverted Papilloma ◽  
Sinonasal Inverted Papilloma ◽  
Sinonasal Papilloma

AbstractObjectives:To explore the pathology, diagnosis, therapeutic strategies and prognosis of primary temporal inverted papilloma.Methods:We present one of the first reported cases of primary temporal inverted papilloma with premalignant change. The available data are reviewed.Results:To the best of our knowledge, only 10 evaluable cases of this tumour have been reported. The recurrence rate is higher for this tumour than for sinonasal inverted papilloma.Conclusion:Primary temporal inverted papilloma is extremely rare, and its diagnosis should be made only following clinical exclusion of sinonasal papilloma. Therapy mainly comprises radical resection of the lesion, and long-term post-operative follow up is mandatory.

Comparison of Current Staging Systems for Sinonasal Inverted Papilloma

2020 ◽  
Vol 35 (1) ◽  
pp. 64-71
Author(s):  
Tsuguhisa Nakayama ◽  
Yasuhiro Tsunemi ◽  
Takashi Kashiwagi ◽  
Akihito Kuboki ◽  
Shuchi Yamakawa ◽  
...  
Keyword(s):  
Disease Free Survival ◽  
Staging System ◽  
Inverted Papilloma ◽  
Machine Learning Algorithms ◽  
Recurrence Rates ◽  
Cox Proportional Hazard ◽  
Sinonasal Inverted Papilloma ◽  
Staging Systems ◽  
Cox Proportional Hazard Models

Background A staging system is essential for determining the optimal surgical approach and predicting postoperative outcomes for inverted papilloma (IP). Although staging systems based on the extent to which the location is occupied by an IP have been widely used, an origin site-based classification of IP using unsupervised machine learning algorithms has recently been reported. Objective To determine the most appropriate of five staging systems for sinonasal IP by comparing recurrence rates for each stage according to each of those systems. Methods Eighty-seven patients with sinonasal IP were enrolled in the study. Their tumors were retrospectively categorized according to the Krouse, Oikawa, Cannady, and Han staging systems, which are based on the extent of IP, and the Meng system, which is based on the site of origin. The rates of recurrence for each stage of the five systems were compared. Results Seven of the 87 patients (8.0%) had recurrences during an average 45.5 months (12–138 months) of follow-up. There were significant differences in disease-free survival between the stages specified by Han and Meng (p = 0.027 and p < 0.001, respectively), but not between the stages specified by Krouse, Oikawa, and Cannady (p = 0.236, 0.062, and 0.130, respectively). Cox proportional hazard models revealed that Meng system (adjusted hazard ratio [aHR] 4.32, 95% confidence interval [CI] 1.10–17.04) and presence of dysplasia (aHR 7.42, 95% CI 1.15–47.85) were significantly associated with recurrence. Conclusion The staging systems proposed by Han and Meng were found to be accurate in terms of tumor recurrence. We recommend use of the Han staging system before surgery and the Meng system after intraoperative identification of the origin of the tumor.

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