scholarly journals Molecular Association of Coronavirus with Diabetes Mellitus Type 2 in Pakistan

2020 ◽  
Vol 7 (1) ◽  
pp. 1-12
Author(s):  
Samreen Riaz ◽  
Keyword(s):  
Infectious Disease ◽  
Diabetes Mellitus Type 2 ◽  
The Novel ◽  
Elevated Blood ◽  
Risk Of Death ◽  
Previous Diagnosis ◽  
Increased Risk ◽  
Sugar Levels ◽  
Novel Coronavirus

Patients with COVID-19 who have elevated blood sugar levels without a previous diagnosis of diabetes may be at a high risk of death and an increased risk of severe complications from the infectious disease, a new study says. We aimed to briefly review the general characteristics of the novel coronavirus (SARS-CoV-2) and provide a better understanding of the coronavirus disease (COVID-19) in people with diabetes, and its management.

scholarly journals Evaluating of the association between ABO blood groups and coronavirus disease 2019 (COVID-19) in Iraqi patients

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Ali H. Ad’hiah ◽  
Risala H. Allami ◽  
Raghdan H. Mohsin ◽  
Maha H. Abdullah ◽  
Ali J. R. AL-Sa’ady ◽  
...  
Keyword(s):  
Blood Groups ◽  
Abo Blood Groups ◽  
Risk Of Death ◽  
Increased Risk ◽  
Fluorescence Probing ◽  
Group A ◽  
Risk Of Disease ◽  
Novel Coronavirus ◽  
Polymorphic System ◽  
Made In

Abstract Background Susceptibility to the pandemic coronavirus disease 2019 (COVID-19) has recently been associated with ABO blood groups in patients of different ethnicities. This study sought to understand the genetic association of this polymorphic system with risk of disease in Iraqi patients. Two outcomes of COVID-19, recovery and death, were also explored. ABO blood groups were determined in 300 hospitalized COVID-19 Iraqi patients (159 under therapy, 104 recovered, and 37 deceased) and 595 healthy blood donors. The detection kit for 2019 novel coronavirus (2019-nCoV) RNA (PCR-Fluorescence Probing) was used in the diagnosis of disease. Results Mean age was significantly increased in patients compared to controls (49.8 ± 11.7 vs. 28.9 ± 6.6 years; p < 0.001). A similar observation was made in recovered (42.1 ± 10.4 vs. 28.9 ± 6.6 years; p < 0.001) and deceased (53.6 ± 9.7 vs. 28.9 ± 6.6 years; p < 0.001) cases. The mean age was also significantly increased in deceased cases compared to recovered cases (53.6 ± 9.7 vs. 42.1 ± 10.4 years; p < 0.001). There were gender-dependent differences in COVID-19 prevalence. The percentage of COVID-19 was higher in males than in females (all cases: 59.7 vs. 40.3%; recovered cases: 55.8 vs. 44.2%). Such male-gender preponderance was more pronounced in deceased cases (67.6 vs. 32.4%). Logistic regression analysis revealed that groups AB and B + AB were significantly associated with increased risk to develop COVID-19 (OR = 3.10; 95% CI 1.59–6.05; pc = 0.007 and OR = 2.16; 95% CI 1.28–3.63; pc = 0.028, respectively). No ABO-associated risk was observed in recovered cases. On the contrary, groups A (OR = 14.60; 95% CI 2.85–74.88; pc = 0.007), AB (OR = 12.92; 95% CI 2.11–79.29; pc = 0.042), A + AB (OR = 14.67; 95% CI 2.98–72.33; pc = 0.007), and A + B + AB (OR = 9.67; 95% CI 2.02–46.24; pc = 0.035) were associated with increased risk of death in deceased cases. Conclusions The findings of this study suggest that group AB may be a susceptibility biomarker for COVID-19, while group A may be associated with increased risk of death.

SARS-COV-2 in type 2 diabetic patients: Possible roles of exercise training as a medicine

2021 ◽  
Vol 17 ◽  
Author(s):  
Mehdi Kushkestani ◽  
Mohsen Parvani ◽  
Yaser Kazemzadeh
Keyword(s):  
Moderate Intensity ◽  
Diabetic Patients ◽  
The Novel ◽  
Compensatory Mechanisms ◽  
Moderate Intensity Exercise ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetics ◽  
Increased Risk ◽  
Complications Rate

: SARS-COV-2 is the novel type of beta coronavirus that was first seen in December 2019 in Wuhan, China. Type 2 Diabetics are one of the groups most vulnerable to SARS-COV-2 and its associated complications. Many factors such as medication, pathophysiologic-induced compensatory mechanisms, and alterations in protein expression and immune system function can all contribute to severe outcomes in diabetics. In this review article, we first described the possible mechanisms of increased risk and more severe complications rate of SARS-COV-2 in diabetic patients. Secondly, we discussed the crucial roles of exercise in diabetic patients and in balancing of RAS system (ACE2/ACE). Finally, we showed the possible roles of acute and chronic exercise in reducing SARS-COV-2 severe outcomes in diabetics in accordance with the latest evidence. We concluded that regular exercise (especially moderate-intensity exercise) can play immune enhancing, anti-inflammatory, anti-oxidation roles and can balance ACE2/ACE ratio (decreasing ANG2 levels) in diabetic subjects.

scholarly journals Vertical Transmission

2020 ◽  
Vol 41 (1) ◽  
pp. 2
Author(s):  
Dena Lyras
Keyword(s):  
Public Health ◽  
Infectious Disease ◽  
Vertical Transmission ◽  
Racial Groups ◽  
The Novel ◽  
Local Part ◽  
Rapid Dissemination ◽  
Novel Coronavirus ◽  
The Impact

As we begin 2020, Microbiology is dominating the news with the emergence and rapid dissemination of the novel coronavirus COVID-19. The impact of COVID-19 on public health, with significant financial, logistical and social repercussions, has quickly become apparent. As microbiologists we have an important role to play during this time because we can use our knowledge, expertise and experience to educate the community around us, and to reduce the panic that results from fear and misinformation. It is also critical that we ensure that racial groups are not stigmatised because of an infectious disease. A co-ordinated global effort is required to tackle this new infectious threat, and we are an important local part of this effort. It is also important to develop strategies that can be deployed when the next threat emerges, as it surely will.

scholarly journals COVID-19 and the Heart

2020 ◽  
pp. 1-5 ◽  
Author(s):  
Chaitanya Rojulpote ◽  
Karthik Gonuguntla ◽  
Shivaraj Patil ◽  
Abhijit Bhattaru ◽  
Paco Bravo
Keyword(s):  
Cardiovascular System ◽  
The Novel ◽  
Health Crisis ◽  
Risk Of Death ◽  
Increased Risk ◽  
The World ◽  
Significant Burden ◽  
Coronary Syndromes ◽  
Novel Virus ◽  
Underlying Mechanisms

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes coronavirus disease 2019 (COVID-19) has resulted in a global health crisis. Prior to the arrival of this viral pandemic, the world was already plagued with a significant burden of cardiovascular disease. With the introduction of the novel virus, the world now faces a double jeapordy. Early reports have suggested an increased risk of death in individuals with underlying cardio-metabolic disorders. The exact effects of COVID-19 on the cardiovascular system are not well determined, however lessons from prior viral epidemics suggest that such infections can trigger acute coronary syndromes, arrhythmias and heart failure via direct and indirect mechanisms. In this article, we aimed to discuss the effects and potential underlying mechanisms of COVID -19 as well as potential implications of treatments targeted against this virus on the cardiovascular system.

scholarly journals The study of correlation between Body Mass Index and glycemic control-HbA1c in diabetes type 2 patients

2019 ◽  
Vol 6 (6) ◽  
pp. 1788
Author(s):  
Rakesh K. Sisodia ◽  
Mahendra Chouhan
Keyword(s):  
Body Mass Index ◽  
Glycaemic Control ◽  
Body Mass ◽  
Normal Weight ◽  
Diabetic Patients ◽  
Poor Glycaemic Control ◽  
Risk Of Death ◽  
Increased Risk ◽  
Type 2 Diabetic

Background: Obesity has major adverse effects on health. Obesity is associated with an increase in mortality, with a 50-100% increased risk of death from all causes compared to normal-weight individuals, mostly due to cardiovascular causes. The aim of this study was to correlate Body Mass Index (BMI) and glycaemic control (HbA1c) in type 2 Diabetic patients.Methods: In this study 100 patients of type 2 diabetic were subjected to detailed history, clinical examination, BMI, HbA1c and routine biochemical investigations.Results: Out of 100 diabetic patients included in this study 62 of them were male and 38 were female. Among 100 patients. Majority of patients were overweight (BMI 25-29.9) which is account to about 58 of total cases, 30 patients were normal BMI and 12 patients were obese. Statistical analysis a positive correlation found between BMI and poor glycaemic control (HbA1c), which is significant.Conclusions: From this study it was concluded that obesity (BMI) is associated with poor glycaemic control.

scholarly journals Nanotechnology against the novel coronavirus (severe acute respiratory syndrome coronavirus 2): diagnosis, treatment, therapy and future perspectives

Nanomedicine ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. 497-516
Author(s):  
Hamid Rashidzadeh ◽  
Hossein Danafar ◽  
Hossein Rahimi ◽  
Faezeh Mozafari ◽  
Marziyeh Salehiabar ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Therapeutic Agents ◽  
Rapid Diagnosis ◽  
Socioeconomic Impact ◽  
The Novel ◽  
Future Perspectives ◽  
Mortality And Morbidity ◽  
Self Assembling ◽  
Novel Coronavirus ◽  
Significant Mortality

COVID-19, as an emerging infectious disease, has caused significant mortality and morbidity along with socioeconomic impact. No effective treatment or vaccine has been approved yet for this pandemic disease. Cutting-edge tools, especially nanotechnology, should be strongly considered to tackle this virus. This review aims to propose several strategies to design and fabricate effective diagnostic and therapeutic agents against COVID-19 by the aid of nanotechnology. Polymeric, inorganic self-assembling materials and peptide-based nanoparticles are promising tools for battling COVID-19 as well as its rapid diagnosis. This review summarizes all of the exciting advances nanomaterials are making toward COVID-19 prevention, diagnosis and therapy.

scholarly journals Estimated glucose disposal rate and risk of stroke and mortality in type 2 diabetes: a nationwide cohort study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Alexander Zabala ◽  
Vladimer Darsalia ◽  
Marcus Lind ◽  
Ann-Marie Svensson ◽  
Stefan Franzén ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Cohort Study ◽  
Cox Regression ◽  
Glucose Disposal ◽  
Risk Of Death ◽  
Increased Risk ◽  
Estimated Glucose Disposal Rate ◽  
Glucose Disposal Rate

Abstract Background and aims Insulin resistance contributes to the development of type 2 diabetes (T2D) and is also a cardiovascular risk factor. The aim of this study was to investigate the potential association between insulin resistance measured by estimated glucose disposal rate (eGDR) and risk of stroke and mortality thereof in people with T2D. Materials and methods Nationwide population based observational cohort study that included all T2D patients from the Swedish national diabetes registry between 2004 and 2016 with full data on eGDR and categorised as following: < 4, 4–6, 6–8, and ≥ 8 mg/kg/min. We calculated crude incidence rates and 95% confidence intervals (CIs) and used multiple Cox regression to estimate hazard ratios (HRs) to assess the association between the risk of stroke and death, according to the eGDR categories in which the lowest category < 4 (i.e., highest grade of insulin resistance), served as a reference. The relative importance attributed of each factor in the eGDR formula was measured by the R2 (± SE) values calculating the explainable log-likelihoods in the Cox regression. Results A total of 104 697 T2D individuals, 44.5% women, mean age of 63 years, were included. During a median follow up-time of 5.6 years, 4201 strokes occurred (4.0%). After multivariate adjustment the HRs (95% CI) for stroke in patients with eGDR categories between 4–6, 6–8 and > 8 were: 0.77 (0.69–0.87), 0.68 (0.58–0.80) and 0.60 (0.48–0.76), compared to the reference < 4. Corresponding numbers for the risk of death were: 0.82 (0.70–0.94), 0.75 (0.64–0.88) and 0.68 (0.53–0.89). The attributed relative risk R2 (± SE) for each variable in the eGDR formula and stroke was for: hypertension (0.045 ± 0.0024), HbA1c (0.013 ± 0.0014), and waist (0.006 ± 0.0009), respectively. Conclusion A low eGDR (a measure of insulin resistance) is associated with an increased risk of stroke and death in individuals with T2D. The relative attributed risk was most important for hypertension.

scholarly journals Thinking Too Much About the Novel Coronavirus. The Link Between Persistent Thinking About COVID-19, SARS-CoV-2 Anxiety and Trauma Effects

2020 ◽  
Author(s):  
Sebastian Skalski ◽  
Patrycja Uram ◽  
Paweł Dobrakowski ◽  
Anna Kwiatkowska
Keyword(s):  
Mental Health ◽  
Infectious Disease ◽  
Regression Analysis ◽  
Psychometric Properties ◽  
Short Form ◽  
Anxiety Scale ◽  
The Novel ◽  
Mental Functioning ◽  
Novel Coronavirus ◽  
Polish Adaptation

Background. Earlier reports have shown that anxiety over the novel coronavirus may predict mental functioning during the pandemic. The objective of this study was to assess the links between persistent thinking about COVID-19, anxiety over SARS-CoV-2 and trauma effects. For the purpose of this study, the Polish adaptation of the Obsession with COVID-19 Scale (OCS) was implemented. Participants and procedure. The study involved 356 individuals aged 18–78 (58% females). In addition to OCS, the participants completed the following questionnaires: the Coronavirus Anxiety Scale and the Short Form of the Changes in Outlook Questionnaire. Results. OCS was characterized by satisfactory psychometric properties (α = .82). Regression analysis indicated that persistent thinking about COVID-19 was associated with increased coronavirus anxiety and negative trauma effects. In addition, anxiety served as a partial mediator in the link between persistent thinking about COVID-19 and negative trauma effects. Conclusions. The data obtained suggest that persistent thinking about the pandemic may be dysfunctional for mental health during the spread of the infectious disease.

scholarly journals Risk and predictors of in-hospital mortality from COVID-19 in patients with diabetes and cardiovascular disease

2020 ◽  
Author(s):  
Hadith Rastad ◽  
Hossein Karim ◽  
Hanieh-Sadat Ejtahed ◽  
Ramin Tajbakhsh ◽  
Mohammad Noorisepehr ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Hospital Mortality ◽  
Lymphocyte Count ◽  
Mortality Data ◽  
Diabetic Patients ◽  
Logistic Regression Models ◽  
Risk Of Death ◽  
Number Of Patients ◽  
Increased Risk ◽  
Novel Coronavirus

Abstract Background: Diabetes mellitus (DM) and cardiovascular disease (CVD) are present in a large number of patients with novel Coronavirus disease 2019 (COVID-19). We aimed to determine the risk and predictors of in-hospital mortality from COVID-19 in patients with DM and CVD.Methods: This retrospective cohort study included hospitalized patients aged ≥ 18 years with confirmed COVID-19 in Alborz province, Iran, from 20 February 2020 to 25 March 2020. Data on demographic, clinical and outcome (in-hospital mortality) data were obtained from electronic medical records. Self-reported comorbidities were classified into the following groups: “DM” (having DM with or without other comorbidities), “only DM” (having DM without other comorbidities), “CVD” (having CVD with or without other comorbidities), “only CVD” (having CVD without other comorbidities), and “having any comorbidity”. Multivariate logistic regression models were fitted to quantify the risk and predictors of in-hospital mortality from COVID-19 in patients with these comorbidities.Results: Among 2957 patients with COVID-19, 2656 were discharged as cured, and 301 died. In multivariate model, DM (OR: 1.62 (95%CI: 1.14-2.30)) and only DM (1.69 (1.05-2.74)) increased the risk of death from COVID-19; but, both CVD and only CVD showed non-significant associations (p>0.05). Moreover, “having any comorbidities” increased the risk of in-hospital mortality from COVID-19 (OR: 2.66 (95%CI: 2.09 -3.40)). Significant predictors of mortality from COVID-19 in patients with DM were lymphocyte count, creatinine and C-reactive protein (CRP) level (all P- values < 0.05).Conclusions: Our findings suggest that diabetic patients have an increased risk of in-hospital mortality following COVID-19; also, lymphocyte count, creatinine and CRP concentrations could be considered as significant predictors for the death of COVID-19 in these patients.

scholarly journals Dilated Cardiomyopathy Risk in Patients with Coronavirus Disease 2019: How to Identify and Characterise it Early?

2020 ◽  
Vol 15 ◽  
Author(s):  
Maki Komiyama ◽  
Koji Hasegawa ◽  
Akira Matsumori
Keyword(s):  
Dilated Cardiomyopathy ◽  
Poor Prognosis ◽  
Myocardial Injury ◽  
The Novel ◽  
Elevated Blood ◽  
Converting Enzyme ◽  
Angiotensin Converting Enzyme 2 ◽  
Direct Binding ◽  
Novel Coronavirus ◽  
Lines Of Evidence

Multiple lines of evidence have shown that elevated blood troponin is strongly associated with poor prognosis in patients with the novel coronavirus disease 2019 (COVID-19). Possible mechanisms of myocardial injury in COVID-19 include ischaemia due to circulatory and respiratory failure, epicardial or intramyocardial small coronary artery thrombotic obstruction due to increased coagulability, and myocarditis caused by systemic inflammation or direct binding of the virus to its receptor, angiotensin-converting enzyme-2 (ACE2), which is abundantly expressed in the heart. It is postulated that persistent immune activation upon viral infection increases the risk of developing dilated cardiomyopathy in COVID-19 patients.

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