scholarly journals Conservation of a historic building through sympathetic thermal enhancement

2015 ◽  
Author(s):  
J. Stinson ◽  
J. Bros Williamson ◽  
A. Reid ◽  
J. Currie
Keyword(s):  
Historic Building ◽  
Thermal Enhancement

scholarly journals Mathematical model for the thermal enhancement of radiation response: thermodynamic approach

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Adriana M. De Mendoza ◽  
Soňa Michlíková ◽  
Johann Berger ◽  
Jens Karschau ◽  
Leoni A. Kunz-Schughart ◽  
...  
Keyword(s):  
Protein Denaturation ◽  
Collateral Damage ◽  
Hyperthermia Treatment ◽  
Reversible Process ◽  
Technological Advances ◽  
Thermal Enhancement ◽  
Main Driver ◽  
Definition Of

AbstractRadiotherapy can effectively kill malignant cells, but the doses required to cure cancer patients may inflict severe collateral damage to adjacent healthy tissues. Recent technological advances in the clinical application has revitalized hyperthermia treatment (HT) as an option to improve radiotherapy (RT) outcomes. Understanding the synergistic effect of simultaneous thermoradiotherapy via mathematical modelling is essential for treatment planning. We here propose a theoretical model in which the thermal enhancement ratio (TER) relates to the cell fraction being radiosensitised by the infliction of sublethal damage through HT. Further damage finally kills the cell or abrogates its proliferative capacity in a non-reversible process. We suggest the TER to be proportional to the energy invested in the sensitisation, which is modelled as a simple rate process. Assuming protein denaturation as the main driver of HT-induced sublethal damage and considering the temperature dependence of the heat capacity of cellular proteins, the sensitisation rates were found to depend exponentially on temperature; in agreement with previous empirical observations. Our findings point towards an improved definition of thermal dose in concordance with the thermodynamics of protein denaturation. Our predictions well reproduce experimental in vitro and in vivo data, explaining the thermal modulation of cellular radioresponse for simultaneous thermoradiotherapy.

Thermal insulating plaster as a solution for refurbishing historic building envelopes: First experimental results

2015 ◽  
Vol 95 ◽  
pp. 86-91 ◽  
Author(s):  
Lorenza Bianco ◽  
Valentina Serra ◽  
Stefano Fantucci ◽  
Marco Dutto ◽  
Marco Massolino
Keyword(s):  
Experimental Results ◽  
Building Envelopes ◽  
Historic Building ◽  
Thermal Insulating

scholarly journals Thermal enhancement and stochastic resonance of polaron ratchets

2014 ◽  
Vol 89 (6) ◽  
Author(s):  
L. S. Brizhik ◽  
A. A. Eremko ◽  
B. M. A. G. Piette ◽  
W. J. Zakrzewski
Keyword(s):  
Stochastic Resonance ◽  
Thermal Enhancement

Optimizing the factors which modify thermal enhancement of melphalan in a spontaneous murine tumor

2006 ◽  
Vol 58 (6) ◽  
pp. 719-724 ◽  
Author(s):  
Faheez Mohamed ◽  
O. Anthony Stuart ◽  
Olivier Glehen ◽  
Muneyasu Urano ◽  
Paul H. Sugarbaker
Keyword(s):  
Murine Tumor ◽  
Thermal Enhancement

44 Hipec Therapy-A New Development to Fight Cancer; Report Of 3 Cases

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
P Prakash Narayan ◽  
R Dutta
Keyword(s):  
Peritoneal Dissemination ◽  
Chemotherapeutic Agents ◽  
Peritoneal Surface Malignancy ◽  
Chemotherapy Treatment ◽  
Peritoneal Carcinomatosis Index ◽  
Thermal Enhancement ◽  
New Development ◽  
Operative Recovery ◽  
Disease Specific

Abstract Introduction HIPEC is highly concentrated, heated chemotherapy treatment that is delivered directly to the abdomen during surgery. HIPEC delivers chemotherapy directly to cancer cells in abdomen. Cytoreductive surgery(CRS) combined with perioperative intraperitoneal chemotherapy is currently a valid treatment option for peritoneal dissemination of gastrointestinal, gynaecological cancers or primary peritoneal neoplasms. Method 3 patients with peritoneal surface malignancy were selected. PET scan was done for all the patients to assess metastasis and peritoneal carcinomatosis index(PCI) calculated was<20 for all 3 patients They were then treated with CRS+HIPEC therapy with disease-specific chemotherapeutic agents like Cisplatin, Mitomycin and Doxorubicin and Oxaliplatin . Aim was Results All the 3 patients had a good post-operative recovery with no recurrence in the follow-up period Conclusions HIPEC and CRS plays synergistic role. A complete CRS followed by HIPEC with the disease-specific chemotherapeutic agent at 41-43ºC constitutes optimal treatment for certain malignancies. High regional concentration with low systemic concentration of chemotherapy, increased tissue penetration and thermal enhancement of cytotoxicity are some of the advantages with HIPEC therapy

Progressive Collapse Evaluation for Historic Building Structures

2010 ◽  
Vol 133-134 ◽  
pp. 1225-1231 ◽  
Author(s):  
Feng Lin ◽  
Ying Wang ◽  
Xiang Lin Gu ◽  
Xin Yuan Zhao
Keyword(s):  
Service Life ◽  
Material Properties ◽  
Progressive Collapse ◽  
Failure Criteria ◽  
Seismic Action ◽  
Historic Buildings ◽  
Building Structures ◽  
Historic Building ◽  
Current Design ◽  
Alternate Path Method

Important historic buildings may be subjected to accidental loads during their service life. It is therefore necessary not only to evaluate their safety under traditional loads and seismic action (only in earthquake area), but also to evaluate the structural performance of resisting progressive collapse. For historic buildings, two aspects make them different from the modern buildings: the material properties are usually deteriorated to some extent, and the structural system/constructions may not meet the requirements of current design and construction codes. Considering such aspects, a method consisting of four steps to evaluate the performance of the historic buildings to resist progressive collapse is presented in this paper. Firstly, the building layout should be evaluated whether it can protect the occupants from the possible explosion. Secondly, geometrical information, structural constructions and the material properties are to be investigated in details. Thirdly, by means of tie force method and the alternate path method the performance of the structure is analyzed to resist progressive collapse. The load combinations used in the analysis are derived based on the expected service life of the structure. The failure criteria for the structural elements as well as the damage limits for the structure follow the provisions addressed in American Unified Facilities Criteria “Design of Structure to Resist Progressive Collapse” (UFC 4-023-03). Finally, based on the above information an overall evaluation is made for the probably structural retrofitting and strengthening. This method is illustrated with a case study of a steel frame historic building, namely the Bund 18 building, in Shanghai, China. Some suggestions for retrofitting and strengthening this building are also presented.

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