Experimental study on Neural stem cell transplantation therapy modified by the gene of tyrosine hydroxylase and Glial cell line derived neurotrophic factor for Parkinson's disease rat model

2014 ◽  
Author(s):  
Haijuna Wang ◽  
Ye Luo ◽  
Ziying Liu ◽  
Chunxi Man
Keyword(s):  
Experimental Study ◽  
Stem Cell ◽  
Tyrosine Hydroxylase ◽  
Stem Cell Transplantation ◽  
Cell Line ◽  
Glial Cell ◽  
Rat Model ◽  
Neurotrophic Factor ◽  
Cell Transplantation Therapy ◽  
Transplantation Therapy

scholarly journals Stem cell transplantation and/or adenoviral glial cell line-derived neurotrophic factor promote functional recovery in hemiparkinsonian rats

2021 ◽  
Vol 13 (1) ◽  
pp. 78-90
Author(s):  
May-Jywan Tsai ◽  
Shih-Chieh Hung ◽  
Ching-Feng Weng ◽  
Su-Fen Fan ◽  
Dann-Ying Liou ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Line ◽  
Glial Cell ◽  
Cell Transplantation ◽  
Functional Recovery ◽  
Neurotrophic Factor

scholarly journals Preconditioned and Genetically Modified Stem Cells for Myocardial Infarction Treatment

2020 ◽  
Vol 21 (19) ◽  
pp. 7301 ◽  
Author(s):  
Kamila Raziyeva ◽  
Aiganym Smagulova ◽  
Yevgeniy Kim ◽  
Saltanat Smagul ◽  
Ayan Nurkesh ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cells ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Heart Function ◽  
Cellular Reprogramming ◽  
Genetic Manipulations ◽  
Cell Transplantation Therapy ◽  
Transplantation Therapy

Ischemic heart disease and myocardial infarction remain leading causes of mortality worldwide. Existing myocardial infarction treatments are incapable of fully repairing and regenerating the infarcted myocardium. Stem cell transplantation therapy has demonstrated promising results in improving heart function following myocardial infarction. However, poor cell survival and low engraftment at the harsh and hostile environment at the site of infarction limit the regeneration potential of stem cells. Preconditioning with various physical and chemical factors, as well as genetic modification and cellular reprogramming, are strategies that could potentially optimize stem cell transplantation therapy for clinical application. In this review, we discuss the most up-to-date findings related to utilizing preconditioned stem cells for myocardial infarction treatment, focusing mainly on preconditioning with hypoxia, growth factors, drugs, and biological agents. Furthermore, genetic manipulations on stem cells, such as the overexpression of specific proteins, regulation of microRNAs, and cellular reprogramming to improve their efficiency in myocardial infarction treatment, are discussed as well.

scholarly journals Enhancement of Tyrosine Hydroxylase Phosphorylation and Activity by Glial Cell Line-derived Neurotrophic Factor

2003 ◽  
Vol 279 (3) ◽  
pp. 2182-2191 ◽  
Author(s):  
Nobuhide Kobori ◽  
Jack C. Waymire ◽  
John W. Haycock ◽  
Guy L. Clifton ◽  
Pramod K. Dash
Keyword(s):  
Tyrosine Hydroxylase ◽  
Cell Line ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Tyrosine Hydroxylase Phosphorylation

scholarly journals Stem cell transplantation therapy for multifaceted therapeutic benefits after stroke

2017 ◽  
Vol 157 ◽  
pp. 49-78 ◽  
Author(s):  
Ling Wei ◽  
Zheng Z. Wei ◽  
Michael Qize Jiang ◽  
Osama Mohamad ◽  
Shan Ping Yu
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Therapeutic Benefits ◽  
Cell Transplantation Therapy ◽  
Transplantation Therapy
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