Effects of simvastatin on bone mass and biomechanical properties of lumbar vertebra in ovariectomized rat

2014 ◽  
Author(s):  
Zhiwei Lv ◽  
Yue Wang ◽  
Faming Tian
Keyword(s):  
Bone Mass ◽  
Lumbar Vertebra ◽  
Biomechanical Properties ◽  
Ovariectomized Rat

scholarly journals Association between Visceral and Bone Marrow Adipose Tissue and Bone Quality in Sedentary and Physically Active Ovariectomized Wistar Rats

Life ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 478
Author(s):  
Hélder Fonseca ◽  
Andrea Bezerra ◽  
Ana Coelho ◽  
José Alberto Duarte
Keyword(s):  
Physical Activity ◽  
Bone Marrow ◽  
Adipose Tissue ◽  
Bone Mass ◽  
Bone Quality ◽  
Wistar Rats ◽  
Biomechanical Properties ◽  
Physically Active ◽  
Bone Formation Rate ◽  
Marrow Adiposity

Background: Obesity is considered protective for bone mass, but this view has been progressively challenged. Menopause is characterized by low bone mass and increased adiposity. Our aim was to determine how visceral and bone marrow adiposity change following ovariectomy (OVX), how they correlate with bone quality and if they are influenced by physical activity. Methods: Five-month-old Wistar rats were OVX or sham-operated and maintained in sedentary or physically active conditions for 9 months. Visceral and bone marrow adiposity as well as bone turnover, femur bone quality and biomechanical properties were assessed. Results: OVX resulted in higher weight, visceral and bone marrow adiposity. Visceral adiposity correlated inversely with femur Ct.Th (r = −0.63, p < 0.001), BV/TV (r = −0.67, p < 0.001), Tb.N (r = −0.69, p < 0.001) and positively with Tb.Sp (r = 0.58, p < 0.001). Bone marrow adiposity also correlated with bone resorption (r = 0.47, p < 0.01), bone formation rate (r = −0.63, p < 0.01), BV/TV (r = −0.85, p < 0.001), Ct.Th (r = −0.51, p < 0.0.01), and with higher empty osteocyte lacunae (r = 0.39, p < 0.05), higher percentage of osteocytes with oxidative stress (r = 0.64, p < 0.0.01) and lower femur maximal stress (r = −0.58, p < 0.001). Physical activity correlated inversely with both visceral (r = −0.74, p < 0.01) and bone marrow adiposity (r = −0.92, p < 0.001). Conclusions: OVX increases visceral and bone marrow adiposity which are associated with inferior bone quality and biomechanical properties. Physical activity could contribute to reduce adipose tissue and thereby improve bone quality.

Effects of risedronate on trabecular microstructure and biomechanical properties in ovariectomized rat tibia

2005 ◽  
Vol 16 (9) ◽  
pp. 1042-1048 ◽  
Author(s):  
Masako Ito ◽  
Akifumi Nishida ◽  
Kiyoshi Aoyagi ◽  
Masataka Uetani ◽  
Kuniaki Hayashi ◽  
...  
Keyword(s):  
Biomechanical Properties ◽  
Ovariectomized Rat ◽  
Trabecular Microstructure ◽  
Rat Tibia

Effect of calcitonin on bone mass of the ovariectomized rat mandible

Bone ◽  
1992 ◽  
Vol 13 (5) ◽  
pp. A37-A37
Author(s):  
T.M. Hang ◽  
C.L. Lin ◽  
C. Shih
Keyword(s):  
Bone Mass ◽  
Ovariectomized Rat ◽  
Rat Mandible

scholarly journals Mice Lacking the Matrilin Family of Extracellular Matrix Proteins Develop Mild Skeletal Abnormalities and Are Susceptible to Age-Associated Osteoarthritis

2020 ◽  
Vol 21 (2) ◽  
pp. 666 ◽  
Author(s):  
Ping Li ◽  
Lutz Fleischhauer ◽  
Claudia Nicolae ◽  
Carina Prein ◽  
Zsuzsanna Farkas ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Articular Cartilage ◽  
Growth Plate ◽  
Lumbar Vertebra ◽  
Adaptor Proteins ◽  
Biomechanical Properties ◽  
Dominant Negative ◽  
Endochondral Bone Formation ◽  
Appendicular Skeleton ◽  
Skeletal Phenotype

Matrilins (MATN1, MATN2, MATN3 and MATN4) are adaptor proteins of the cartilage extracellular matrix (ECM), which bridge the collagen II and proteoglycan networks. In humans, dominant-negative mutations in MATN3 lead to various forms of mild chondrodysplasias. However, single or double matrilin knockout mice generated previously in our laboratory do not show an overt skeletal phenotype, suggesting compensation among the matrilin family members. The aim of our study was to establish a mouse line, which lacks all four matrilins and analyze the consequence of matrilin deficiency on endochondral bone formation and cartilage function. Matn1-4−/− mice were viable and fertile, and showed a lumbosacral transition phenotype characterized by the sacralization of the sixth lumbar vertebra. The development of the appendicular skeleton, the structure of the growth plate, chondrocyte differentiation, proliferation, and survival were normal in mutant mice. Biochemical analysis of knee cartilage demonstrated moderate alterations in the extractability of the binding partners of matrilins in Matn1-4−/− mice. Atomic force microscopy (AFM) revealed comparable compressive stiffness but higher collagen fiber diameters in the growth plate cartilage of quadruple mutant compared to wild-type mice. Importantly, Matn1-4−/− mice developed more severe spontaneous osteoarthritis at the age of 18 months, which was accompanied by changes in the biomechanical properties of the articular cartilage. Interestingly, Matn4−/− mice also developed age-associated osteoarthritis suggesting a crucial role of MATN4 in maintaining the stability of the articular cartilage. Collectively, our data provide evidence that matrilins are important to protect articular cartilage from deterioration and are involved in the specification of the vertebral column.

Preservation of bone mass and biomechanical properties during winter sleep—the raccoon dog (Nyctereutes procyonoides) as a novel model species

Bone ◽  
2011 ◽  
Vol 48 (4) ◽  
pp. 878-884 ◽  
Author(s):  
Petteri Nieminen ◽  
Mikko A.J. Finnilä ◽  
Juha Tuukkanen ◽  
Timo Jämsä ◽  
Anne-Mari Mustonen
Keyword(s):  
Bone Mass ◽  
Biomechanical Properties ◽  
Nyctereutes Procyonoides ◽  
Raccoon Dog ◽  
Model Species ◽  
Novel Model ◽  
Winter Sleep

scholarly journals Effects of fructans-containing yacon (Smallanthus sonchifoliusPoepp & Endl.) flour on caecum mucosal morphometry, calcium and magnesium balance, and bone calcium retention in growing rats

2007 ◽  
Vol 97 (4) ◽  
pp. 776-785 ◽  
Author(s):  
Alexandre R. Lobo ◽  
Célia Colli ◽  
Eliana P. Alvares ◽  
Tullia M. C. C. Filisetti
Keyword(s):  
Bone Mass ◽  
Bone Mineral ◽  
Peak Load ◽  
Biomechanical Testing ◽  
Biomechanical Properties ◽  
Control Group ◽  
Mineral Density ◽  
Tissue Samples ◽  
Mineral Absorption ◽  
Positive Effects

Yacon roots have been considered a functional food due to the high levels of fructans they contains. In the present study, Ca and Mg balance, bone mass and strength, and caecum mucosal morphometry were evaluated. Growing male Wistar rats (n24) were fedad libitumcontrol diets or diets supplemented with yacon flour (5 or 7·5 % fructooligosaccharides) for 27 d. Mineral balance was evaluated in three periods of 5 d (starting on the 4th, 10th and 16th days). After the rats were killled, the bones were removed and bone mineral density was measured. Ca analyses were performed on left femurs and tibias and biomechanical testing on right femurs. The caecum was removed and tissue samples were collected for histological analysis. Caecal histology changed noticeably in rats fed yacon flour: there was an increase in the depth and number of total and bifurcated crypts as well. Yacon flour consumption significantly (P < 0·05) resulted in a positive Ca and Mg balance, leading to higher values of bone mineral retention and biomechanical properties (peak load and stiffness) when compared to the control group. The positive effects on mineral intestinal absorption, bone mass and biomechanical properties showed an important role of yacon roots in the maintenance of healthy bones. The increased number of bifurcating crypts might be related to the higher mineral absorption caused by the enlargement of the absorbing surface in the large intestine of the animals.

Effects of Low-Dose Long-Term Sodium Fluoride Preventive Treatment on Rat Bone Mass and Biomechanical Properties

1996 ◽  
Vol 58 (1) ◽  
pp. 30-39 ◽  
Author(s):  
Y. Jiang ◽  
J. Zhao ◽  
R. Van Audekercke ◽  
J. Dequeker ◽  
P. Geusens
Keyword(s):  
Bone Mass ◽  
Sodium Fluoride ◽  
Low Dose ◽  
Preventive Treatment ◽  
Biomechanical Properties ◽  
Rat Bone

scholarly journals A western-style diet reduces bone mass and biomechanical bone strength to a greater extent in male compared with female rats during development

2003 ◽  
Vol 90 (3) ◽  
pp. 589-595 ◽  
Author(s):  
Wendy E. Ward ◽  
Susie Kim ◽  
W. Robert Bruce
Keyword(s):  
Folic Acid ◽  
Weight Gain ◽  
Bone Mass ◽  
Bone Strength ◽  
Control Diet ◽  
Biomechanical Properties ◽  
Female Rats ◽  
Male Rats ◽  
Male And Female ◽  
Male And Female Rats

Evidence from epidemiological and animal-feeding trials suggests that a western-style diet that is high in fat, and low in Ca, vitamin D and folic acid may result in low bone mass and poor bone quality: this leads to an increased risk of fragility fracture. The overall objective of the present study was to determine the effect of feeding a western-style diet (low in Ca (0·4 g/kg diet, Ca:P ratio 1:10), cholecalciferol (3 μg/kg diet), folic acid (0·23 mg/kg diet) and fibre (20 g/kg diet), and high in fat (200 g/kg diet)) for 17 weeks on bone mineral content (BMC) and the biomechanical bone strength of rat femurs. A secondary objective was to determine whether femurs from male and female rats (seven to eight rats per group) respond differently to the western-style diet. Male and female rats weighing 150–180 g were fed a western-style diet or a control diet for 17 weeks. At the end of the feeding trial, femur BMC was measured by ashing, and biomechanical properties were determined by three-point bending. Femur BMC and the majority of biomechanical properties measured were lower (P<0·05) among male and female rats fed a western-style diet compared with a control diet, despite similar weight gain and final body weight within genders. However, the western-style diet had a greater negative effect on femur BMC and biomechanical strength properties among male rats compared with females. This may be because male rats experienced greater overall body growth, as assessed by weight gain, than female rats, and suggests that the nutrient composition of the western-style diet did not support the development of strong femurs.

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