scholarly journals Environmental diagnosis in areas with different use and occupation using the perception of diverse biological activity

2012 ◽  
Author(s):  
A. I. Ribeiro ◽  
A. Peche Filho ◽  
G. A. de Medeiros ◽  
R. M. Longo ◽  
M. Storino ◽  
...  
Keyword(s):  
Biological Activity ◽  
Diverse Biological Activity

scholarly journals Synthesis, the structure of arylsalicylic amides, which have anthelmintic activity

2019 ◽  
Vol 57 (3) ◽  
pp. 58-70
Author(s):  
Anna Yu. Malakhova ◽  
◽  
Vladimir N. Kuklin ◽  
Keyword(s):  
Veterinary Medicine ◽  
Biological Activity ◽  
Organic Compounds ◽  
Anthelmintic Activity ◽  
Hydroxyl Group ◽  
Main Condition ◽  
Structure Activity ◽  
Acid Fragment ◽  
Antifungal Substances ◽  
Diverse Biological Activity

Salicylamides (N-aryl-substituted hydroxybenzamides): well-known organic compounds with diverse biological activity, which were originally investigated as antimicrobial and antifungal substances. Salicylamides have also been used as anthelmintic or molluscicidal agents in human and veterinary medicine. The most famous is 5,2'-dichloro-4'-nitrosalicylamide (niclosamide, yomezan – Germany), resynthesized in the USSR under the name of fenasal, which is effective in treating diphyllobothriasis and hymenolepidosis and has molluscicidal properties. The works of domestic and foreign scientists F.S. Mikhaylitsyn, H. Vanden Bosshe, L.M. Scheibel, P. Andreus, G. Bonse, and others are devoted to the synthesis of salicylamides, their biological activity. I. Arkhipov, R. Gonnert, studied the anthelmintic activity of salicylamides. E. Schraufstatter, H. Mrozik et al. In the works of various authors the “structure-activity linkage” of the synthesized amides is shown. It has been established that the presence of an amide or thioamide bond, substituted amides, is important for anthelmintic activity. The presence of a hydroxyl group in the 2nd position of the aromatic ring of the salicylamide acid fragment is the main condition for the manifestation of activity with respect to tape helminths and trematodes. The best profile of the biological activity of salicylamides was obtained by introducing chlorine into various positions of acid and amine fragments. Acylation of the hydroxyl group in salicylamides leads to a decrease in their toxicity.

Current Advances on the Extraction and Identification of Bioactive Components of Sage (Salvia spp.)

2019 ◽  
Vol 20 (10) ◽  
pp. 845-857
Author(s):  
Efthymios Poulios ◽  
Constantinos Giaginis ◽  
Georgios K. Vasios
Keyword(s):  
Biological Activity ◽  
Phenolic Content ◽  
Common Species ◽  
Polyphenolic Compounds ◽  
Total Phenolic ◽  
Bioactive Components ◽  
Aromatic Plant ◽  
Anticancer Properties ◽  
Salvia Officinalis L ◽  
Diverse Biological Activity

Common sage (Salvia spp., with the most common species Salvia officinalis L., Lamiaceae) is an important medicinal and aromatic plant, with antioxidant, antimicrobial, anti-inflammatory and anticancer properties. The polyphenolic compounds are mainly responsible for its diverse biological activity. Many different methods for extraction and identification of sage bioactive compounds, using various solvents, have been developed in recent years. The total phenolic content is usually measured and identified by various technical methodologies with different sensitivity and specificity. In this aspect, the present review is aimed to critically summarize and discuss various technical approaches for the extraction and identification of sage bioactive components in order to point out the more appropriate approaches of them.

Meleagrin from marine fungus Emericella dentata Nq45: crystal structure and diverse biological activity studies

2020 ◽  
pp. 1-9 ◽  
Author(s):  
Abdelaaty Hamed ◽  
Ahmed S. Abdel-Razek ◽  
Mariam Araby ◽  
Mohammed Abu-Elghait ◽  
Doaa G. El-Hosari ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Biological Activity ◽  
Marine Fungus ◽  
Diverse Biological Activity

ARTS, the unusual septin: structural and functional aspects

2011 ◽  
Vol 392 (8-9) ◽  
pp. 783-790 ◽  
Author(s):  
Yael Mandel-Gutfreund ◽  
Idit Kosti ◽  
Sarit Larisch
Keyword(s):  
Biological Activity ◽  
Intron Retention ◽  
Membrane Dynamics ◽  
Protein Isoforms ◽  
Major Protein ◽  
Cytoskeletal Reorganization ◽  
Differential Splicing ◽  
Functional Aspects ◽  
Structural And Functional Properties ◽  
Diverse Biological Activity

AbstractThe humanSeptin 4gene (Sept4) encodes two major protein isoforms; Sept4_i1 (H5/PNUTL2) and Sept4_i2/ARTS. Septins have been traditionally studied for their role in cytokinesis and their filament-forming abilities, but subsequently have been implicated in diverse functions, including membrane dynamics, cytoskeletal reorganization, vesicle trafficking, and tumorigenesis. ARTS is localized at mitochondria and promotes programmed cell death (apoptosis). These features distinguish ARTS from any other known human septin family member. This review compares the structural and functional properties of ARTS with other septins. In addition, it describes how a combination of two distinct promoters, differential splicing, and intron retention leads to the generation of two different Sept4 variants with diverse biological activity.

Endotoxins affect diverse biological activity of chitosans in matters of hemocompatibility and cytocompatibility

2014 ◽  
Vol 25 (9) ◽  
pp. 2121-2130 ◽  
Author(s):  
Andrea Nolte ◽  
Susanne Hossfeld ◽  
Marcell Post ◽  
Jan Niederlaender ◽  
Tobias Walker ◽  
...  
Keyword(s):  
Biological Activity ◽  
Diverse Biological Activity

Chitosan and Its Derivatives - Biomaterials with Diverse Biological Activity for Manifold Applications

2019 ◽  
Vol 19 (9) ◽  
pp. 737-750 ◽  
Author(s):  
Paulina Paul ◽  
Beata Kolesinska ◽  
Witold Sujka
Keyword(s):  
Biological Activity ◽  
Biomedical Applications ◽  
Chemical Properties ◽  
Alkaline Solutions ◽  
Chemical Modifications ◽  
Solubility In Water ◽  
Chitosan Derivatives ◽  
Main Obstacle ◽  
Derivatives Of ◽  
Diverse Biological Activity

Derived from chitin, chitosan is a natural polycationic linear polysaccharide being the second most abundant polymer next to cellulose. The main obstacle in the wide use of chitosan is its almost complete lack of solubility in water and alkaline solutions. To break this obstacle, the structure of chitosan is subjected to modification, improving its physic-chemical properties and facilitating application as components of composites or hydrogels. Derivatives of chitosan are biomaterials useful for different purposes because of their lack of toxicity, low allergenicity, biocompatibility and biodegradability. This review presents the methods of chemical modifications of chitosan which allow to obtain tailor- made properties required for a variety of biomedical applications. Selected pharmaceutical and biomedical applications of chitosan derivatives are also highlighted. Possibility to manage waste from arthropod and crab processing is also emphasized.

scholarly journals Preparation, Characterization, and Cytotoxicity of Various Chitosan Nanoparticles

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Qian Yao ◽  
Wei Liu ◽  
Xiao-Jun Gou ◽  
Xiao-Qiang Guo ◽  
Jun Yan ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Biological Activity ◽  
Hepg2 Cells ◽  
Drug Loading ◽  
Chitosan Nanoparticles ◽  
Inhibitory Effect ◽  
Hepatic Carcinoma ◽  
Transmission Electron ◽  
Diverse Biological Activity

Chitosan nanoparticles (CS-NPs) without drug loading have diverse biological activity. In this study, we prepared CS-NPs, CS-NPs solidified by different amount of glutaraldehyde, and CS-NPs modified with either biotin (B-CS-NPs) or biotin and avidin (A-B-CS-NPs) and examined their cytotoxicity on HepG2 cells. The morphology and size were measured by transmission electron microscopy and photon correction spectroscopy, respectively. The extent of solidification was validated by the approach of sonication. Biotin connect density on the surface of B-CS-NPs and A-B-CS-NPs was determined by biotin assay kit. The results showed that most of the NPs were round and their mean sizes were all below 300 nm. Biotin connect density of B-CS-NPs and A-B-CS-NPs was 2.18 ± 0.36 and 1.26 ± 0.11 mol biotin/mol CS, respectively. At relatively low concentration, CS-NPs with higher extent of solidification exhibited more vigorous inhibitory effect against HepG2 cells than those without solidification. When NPs were incubated with cancer cells for 48 h, compared with CS-NPs, the anticancer activity of B-CS-NPs and A-B-CS-NPs was enhanced significantly(P<0.05). In addition, A-B-CS-NPs showed superior cytotoxicity over B-CS-NPs. This study demonstrates that modification with biotin and avidin may be an efficient way in improving antitumor activity of CS-NPs against hepatic carcinoma.

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