scholarly journals Use of the in vitro model for the evaluation of toxic effects of metabolites produced by fungi

2007 ◽  
Author(s):  
Z. Kováčiková ◽  
E. Piecková ◽  
E. Tátrai ◽  
Z. Pivovarová ◽  
M. Mataušic-Pišl
Keyword(s):  
In Vitro Model ◽  
Toxic Effects ◽  
Vitro Model

Bovine chromaffin cells as in vitro model for the study of the non cholinergic toxic effects of the organophosphorus compound

1996 ◽  
Vol 88 ◽  
pp. 9-10
Author(s):  
Miguel A. Sogorb ◽  
Sonia Bas ◽  
Luis Miguel Gutiérrez ◽  
Eugenio Vilanova ◽  
Salvador Viniegra
Keyword(s):  
Organophosphorus Compound ◽  
Chromaffin Cells ◽  
In Vitro Model ◽  
Toxic Effects ◽  
Bovine Chromaffin Cells ◽  
Vitro Model

Doxorubicin-Mediated Toxic Effects Are Mediated Via NO/eNOS in a Novel 3D in Vitro Model of the Human Heart

2016 ◽  
Vol 100 ◽  
pp. S142
Author(s):  
Liudmila Polonchuk ◽  
Mamta Chabria ◽  
Michael J. Davies ◽  
Carmine Gentile
Keyword(s):  
Human Heart ◽  
In Vitro Model ◽  
Toxic Effects ◽  
3D In Vitro Model ◽  
Vitro Model

An in vitro model for investigation of vitamin A effects on wound healing

2021 ◽  
pp. 1-6
Author(s):  
Hoda Keshmiri Neghab ◽  
Mohammad Hasan Soheilifar ◽  
Gholamreza Esmaeeli Djavid
Keyword(s):  
Wound Healing ◽  
Endothelial Cell ◽  
Vitamin A ◽  
In Vitro Model ◽  
Cellular Proliferation ◽  
Endothelial Cell Migration ◽  
Normal Fibroblast ◽  
Anti Inflammatory ◽  
Vitro Model

Abstract. Wound healing consists of a series of highly orderly overlapping processes characterized by hemostasis, inflammation, proliferation, and remodeling. Prolongation or interruption in each phase can lead to delayed wound healing or a non-healing chronic wound. Vitamin A is a crucial nutrient that is most beneficial for the health of the skin. The present study was undertaken to determine the effect of vitamin A on regeneration, angiogenesis, and inflammation characteristics in an in vitro model system during wound healing. For this purpose, mouse skin normal fibroblast (L929), human umbilical vein endothelial cell (HUVEC), and monocyte/macrophage-like cell line (RAW 264.7) were considered to evaluate proliferation, angiogenesis, and anti-inflammatory responses, respectively. Vitamin A (0.1–5 μM) increased cellular proliferation of L929 and HUVEC (p < 0.05). Similarly, it stimulated angiogenesis by promoting endothelial cell migration up to approximately 4 fold and interestingly tube formation up to 8.5 fold (p < 0.01). Furthermore, vitamin A treatment was shown to decrease the level of nitric oxide production in a dose-dependent effect (p < 0.05), exhibiting the anti-inflammatory property of vitamin A in accelerating wound healing. These results may reveal the therapeutic potential of vitamin A in diabetic wound healing by stimulating regeneration, angiogenesis, and anti-inflammation responses.

A new in vitro model for pre-transplantation diagnosis of frozen/thawed human ovarian tissue

2011 ◽  
Vol 71 (05) ◽  
Author(s):  
M Salama ◽  
K Winkler ◽  
KF Murach ◽  
S Hofer ◽  
L Wildt ◽  
...  
Keyword(s):  
In Vitro Model ◽  
Ovarian Tissue ◽  
Human Ovarian Tissue ◽  
Vitro Model
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