scholarly journals State of the art of solid freeform fabrication for soft and hard tissue engineering

Author(s):  
P. J. S. Bártolo
2007 ◽  
Vol 90 (6) ◽  
pp. 1703-1708 ◽  
Author(s):  
R. Dittrich ◽  
G. Tomandl ◽  
F. Despang ◽  
A. Bernhardt ◽  
Th. Hanke ◽  
...  

2018 ◽  
Vol 52 ◽  
pp. 101-107 ◽  
Author(s):  
Meda-Romana Simu ◽  
Emoke Pall ◽  
Teodora Radu ◽  
Maria Miclaus ◽  
Bogdan Culic ◽  
...  

2019 ◽  
Vol 34 (4-5) ◽  
pp. 386-400 ◽  
Author(s):  
Moein Zarei ◽  
Nader Tanideh ◽  
Shahrokh Zare ◽  
Fatemeh Sari Aslani ◽  
Omid Koohi-Hosseinabadi ◽  
...  

In the present study, poly(3-hydroxybutyrate)-based composite scaffolds were prepared with multi-walled carbon nanotubes and hydroxyapatite nanoparticles for hard tissue engineering applications by electrospinning. All the prepared scaffolds showed connective porous structure, which were suitable for cell proliferation and migration. The mechanical properties of the poly(3-hydroxybutyrate) scaffold were improved by 0.5% of carbon nanotube addition, whereas the addition of hydroxyapatite nanoparticles up to 10% had an insignificant effect in tensile strength. However, scanning electron microscopy and MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay results suggested that the mesenchymal stem cells attachment and their metabolic activities on the surface of the poly(3-hydroxybutyrate) scaffolds with hydroxyapatite were enhanced compared to poly(3-hydroxybutyrate) scaffolds. In addition, after 6 weeks of in vivo biocompatibility results in a model of rat indicated better tissue reactions for the scaffolds that contained hydroxyapatite. Overall, poly(3-hydroxybutyrate) composite scaffolds with 10% hydroxyapatite and 0.5% carbon nanotube showed optimal performances for the potential scaffold for hard tissue engineering application.


Author(s):  
Yifeng Hong ◽  
Jack G. Zhou ◽  
Donggang Yao

Porous materials with well-defined pore shapes, sizes and distributions are highly desired in many emerging applications, particularly for biomedical materials and devices. However, conventional methods for processing porous materials only demonstrated limited capability in morphological control. One promising solution is the porogen templating process, where a structured porogen pattern is created first and subsequently used as a template or mold for generation of the desired porous material. Particularly, with solid freeform fabrication, porogen templates having complex internal structures can be additively fabricated, and they can then be used as molds for molding of porous materials and devices. This article attempts to offer a constructive overview on the state of the art of porogen patterning and inverse molding, with the goal of explaining the working mechanisms and providing unbiased accounts of the pros and cons of existing techniques and process variants. The article further intends to provide a fundamental understanding of the constituent elements and corresponding building blocks in porogen templating processes. An increased understanding of these elements will facilitate the development of more capable new processes.


2004 ◽  
Vol 860 ◽  
Author(s):  
Gian N. Babini ◽  
Andrea Fedele ◽  
Luca Settineri

ABSTRACTThe great development of Solid Freeform Fabrication (SFF) techniques from their introduction into the market, more than 20 years ago, has fueled their diffusion in the mechanical sector to the point that they are today an indispensable component of the process of designing, engineering and producing a mechanical parts.At the same time, these techniques found application in different and even distant sectors, like biomedicine or architecture. This lead to the necessity of developing SFF processes suitable for materials different from those they were at the beginning thought for. Such techniques, taken from the original ones or entirely developed ex-novo, allowed for a surprising differentiation of the applications.The fabrication of ceramic parts by SFF techniques is a relatively new field which is widening the role of such materials in sectors not traditionally covered.The present paper reports a state of the art of the techniques that appear more effective for the production of ceramic goods, with representative or even functional properties.Further, some results of 3D Printing experiments of alumina parts will be presented.


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