scholarly journals Ischemia-reperfusion injury and oxygen-derived free radicals in isolated perfused rat heart: sarcoplasmic reticulum Ca2+ handling dysfunction.

Ensho ◽  
1997 ◽  
Vol 17 (4) ◽  
pp. 355-364
Author(s):  
Takashi Kiyose ◽  
Eiichiro Okabe
Keyword(s):  
Free Radicals ◽  
Sarcoplasmic Reticulum ◽  
Reperfusion Injury ◽  
Rat Heart ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Perfused Rat Heart ◽  
Isolated Perfused Rat Heart ◽  
Oxygen Derived Free Radicals

Protective effects of an adenosine deaminase inhibitor on ischemia-reperfusion injury in isolated perfused rat heart

1990 ◽  
Vol 259 (3) ◽  
pp. H835-H838 ◽  
Author(s):  
Q. Y. Zhu ◽  
S. G. Chen ◽  
C. M. Zou
Keyword(s):  
Ventricular Fibrillation ◽  
Reperfusion Injury ◽  
Adenosine Deaminase ◽  
Rat Heart ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Treated Group ◽  
Perfused Rat Heart ◽  
Isolated Perfused Rat Heart ◽  
Resting Tension

We tested the effect of the adenosine deaminase inhibitor erythro-9-(2-hydroxy-3-nonyl)adenosine (EHNA) on ischemia-reperfusion injury in isolated perfused rat heart. In the ischemia-reperfusion group (n = 10), ventricular fibrillation occurred within 3 min of reperfusion after the 40-min ischemic period. The incidence of ventricular fibrillation was 90% with a mean duration of 3.15 +/- 0.97 (SE) min. Resting tension increased significantly. By contrast, the incidence of ventricular fibrillation after reperfusion in the EHNA-treated (5 microM) group (n = 10) was 20% (P less than 0.01), and the duration was 0.30 +/- 0.21 min (P less than 0.01). Resting tension was significantly lower and around the normal level in the EHNA-treated group (P less than 0.01). Contraction amplitude and heart rate recovered to nearly normal compared with the ischemia-reperfusion group (P less than 0.01). Coronary flow was greater in the EHNA-treated group (P less than 0.01). It is concluded that EHNA protects the heart, possibly by accumulation of adenosine that benefits the hearts and by blocking the xanthine oxidase pathway for free radical generation.

Influence of antithrombin on ischemia/reperfusion injury in the isolated blood-free perfused rat heart

2002 ◽  
Vol 108 (4) ◽  
pp. 249-255 ◽  
Author(s):  
Josef Margreiter ◽  
Markus Mittermayr ◽  
Johannes Mair ◽  
Angelika Hammerer-Lercher ◽  
Jordan Kountchev ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Rat Heart ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Perfused Rat Heart

scholarly journals Role of Catalase in Ischemia-Reperfusion Injury in the Perfused Rat Heart

1993 ◽  
Vol 5 (2) ◽  
pp. 225-235 ◽  
Author(s):  
Toshiki IWATA ◽  
Noburu KONNO ◽  
Toshikuni YANAGISHITA ◽  
Takashi KATAGIRI
Keyword(s):  
Reperfusion Injury ◽  
Rat Heart ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Perfused Rat Heart
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