Pathogen Associated Molecular Pattern Recognition in Innate Immunity

Ensho Saisei ◽  
2003 ◽  
Vol 23 (4) ◽  
pp. 211-217 ◽  
Author(s):  
Shizuo Akira
Keyword(s):  
Pattern Recognition ◽  
Innate Immunity ◽  
Molecular Pattern ◽  
Pathogen Associated Molecular Pattern

scholarly journals The bacterial quorum sensing signal DSF hijacks Arabidopsis thaliana sterol biosynthesis to suppress plant innate immunity

2020 ◽  
Vol 3 (10) ◽  
pp. e202000720
Author(s):  
Tuan Minh Tran ◽  
Zhiming Ma ◽  
Alexander Triebl ◽  
Sangeeta Nath ◽  
Yingying Cheng ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Arabidopsis Thaliana ◽  
Plasma Membrane ◽  
Quorum Sensing ◽  
Xanthomonas Campestris ◽  
Pathogenic Bacteria ◽  
Specific Effect ◽  
Molecular Pattern ◽  
Pathogen Associated Molecular Pattern ◽  
Bacterial Quorum

Quorum sensing (QS) is a recognized phenomenon that is crucial for regulating population-related behaviors in bacteria. However, the direct specific effect of QS molecules on host biology is largely understudied. In this work, we show that the QS molecule DSF (cis-11-methyl-dodecenoic acid) produced by Xanthomonas campestris pv. campestris can suppress pathogen-associated molecular pattern–triggered immunity (PTI) in Arabidopsis thaliana, mediated by flagellin-induced activation of flagellin receptor FLS2. The DSF-mediated attenuation of innate immunity results from the alteration of FLS2 nanoclusters and endocytic internalization of plasma membrane FLS2. DSF altered the lipid profile of Arabidopsis, with a particular increase in the phytosterol species, which impairs the general endocytosis pathway mediated by clathrin and FLS2 nano-clustering on the plasma membrane. The DSF effect on receptor dynamics and host immune responses could be entirely reversed by sterol removal. Together, our results highlighted the importance of sterol homeostasis to plasma membrane organization and demonstrate a novel mechanism by which pathogenic bacteria use their communicating molecule to manipulate pathogen-associated molecular pattern–triggered host immunity.

scholarly journals Endogenous Molecules Induced by a Pathogen-Associated Molecular Pattern (PAMP) Elicit Innate Immunity in Shrimp

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e115232 ◽  
Author(s):  
Yu-Yuan Chen ◽  
Jiann-Chu Chen ◽  
Yong-Chin Lin ◽  
Suwaree Kitikiew ◽  
Hui-Fang Li ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Molecular Pattern ◽  
Pathogen Associated Molecular Pattern

Plant innate immunity in strawberry induced by pathogen-associated molecular pattern harpin and acibenzolar-S-methyl

2021 ◽  
Author(s):  
Silvia Scariotto ◽  
Vanessa Nataline Tomazeli ◽  
Marcos Vily Paladini ◽  
Cristiane de Oliveira Bolina ◽  
Renato Lustosa Sobrinho ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Plant Innate Immunity ◽  
Molecular Pattern ◽  
Pathogen Associated Molecular Pattern

scholarly journals TNFa and IL2 Encoding Oncolytic Adenovirus Activates Pathogen and Danger-Associated Immunological Signaling

Cells ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 798 ◽  
Author(s):  
Camilla Heiniö ◽  
Riikka Havunen ◽  
Joao Santos ◽  
Klaas de Lint ◽  
Victor Cervera-Carrascon ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Tumor Microenvironment ◽  
Immune Cells ◽  
Oncolytic Adenovirus ◽  
Adenovirus Infection ◽  
Tumor Resistance ◽  
Antitumor Response ◽  
Specific Effects ◽  
Molecular Pattern ◽  
Pathogen Associated Molecular Pattern

In order to break tumor resistance towards traditional treatments, we investigate the response of tumor and immune cells to a novel, cytokine-armed oncolytic adenovirus: Ad5/3-d24-E2F-hTNFa-IRES-hIL2 (also known as TILT-123 and OAd.TNFa-IL2). There are several pattern recognition receptors (PRR) that might mediate adenovirus-infection recognition. However, the role and specific effects of each PRR on the tumor microenvironment and treatment outcome remain unclear. Hence, the aim of this study was to investigate the effects of OAd.TNFa-IL2 infection on PRR-mediated danger- and pathogen-associated molecular pattern (DAMP and PAMP, respectively) signaling. In addition, we wanted to see which PRRs mediate an antitumor response and are therefore relevant for optimizing this virotherapy. We determined that OAd.TNFa-IL2 induced DAMP and PAMP release and consequent tumor microenvironment modulation. We show that the AIM2 inflammasome is activated during OAd.TNFa-IL2 virotherapy, thus creating an immunostimulatory antitumor microenvironment.

scholarly journals Identification of MicroRNAs Involved in Pathogen-Associated Molecular Pattern-Triggered Plant Innate Immunity

2010 ◽  
Vol 152 (4) ◽  
pp. 2222-2231 ◽  
Author(s):  
Yan Li ◽  
QingQing Zhang ◽  
Jiangguang Zhang ◽  
Liang Wu ◽  
Yijun Qi ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Plant Innate Immunity ◽  
Molecular Pattern ◽  
Pathogen Associated Molecular Pattern
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