scholarly journals Signaling through class II MHC molecules

Ensho Saisei ◽  
2001 ◽  
Vol 21 (5) ◽  
pp. 541-555
Author(s):  
Sho Matsushita
Keyword(s):  
Class Ii ◽  
Mhc Molecules ◽  
Class Ii Mhc

Electron microscopy analysis of degenerating pancreatic ß cells in transgenic mice expressing the MHC Class I antigen Dd

1990 ◽  
Vol 48 (3) ◽  
pp. 548-549
Author(s):  
T. A. Stewart ◽  
D. Liggitt ◽  
S. Pitts ◽  
L. Martin ◽  
M. Siegel ◽  
...  
Keyword(s):  
Type I Diabetes ◽  
Disease Process ◽  
Class Ii ◽  
Class I ◽  
Type I ◽  
Aberrant Expression ◽  
Mhc Molecules ◽  
Endogenous Insulin ◽  
Class Ii Mhc ◽  
Ifn Γ

Insulin-dependant (Type I) diabetes mellitus (IDDM) is a metabolic disorder resulting from the lack of endogenous insulin secretion. The disease is thought to result from the autoimmune mediated destruction of the insulin producing ß cells within the islets of Langerhans. The disease process is probably triggered by environmental agents, e.g. virus or chemical toxins on a background of genetic susceptibility associated with particular alleles within the major histocompatiblity complex (MHC). The relation between IDDM and the MHC locus has been reinforced by the demonstration of both class I and class II MHC proteins on the surface of ß cells from newly diagnosed patients as well as mounting evidence that IDDM has an autoimmune pathogenesis. In 1984, a series of observations were used to advance a hypothesis, in which it was suggested that aberrant expression of class II MHC molecules, perhaps induced by gamma-interferon (IFN γ) could present self antigens and initiate an autoimmune disease. We have tested some aspects of this model and demonstrated that expression of IFN γ by pancreatic ß cells can initiate an inflammatory destruction of both the islets and pancreas and does lead to IDDM.

MHC Sınıf I ve MHC Sınıf II Gen Düzenlenmesi

2020 ◽  
Vol 8 (3) ◽  
pp. 144-156
Author(s):  
Şule KARATAŞ ◽  
Fatma SAVRAN OĞUZ
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Gene Regulation ◽  
Mhc Class I ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Class I ◽  
Mhc Molecules ◽  
Class Ii Mhc ◽  
Regulation Mechanisms

Introduction: Peptides obtained by processing intracellular and extracellular antigens are presented to T cells to stimulate the immune response. This presentation is made by peptide receptors called major histocompatibility complex (MHC) molecules. The regulation mechanisms of MHC molecules, which have similar roles in the immune response, especially at the gene level, have significant differences according to their class. Objective: Class I and class II MHC molecules encoded by MHC genes on the short arm of the sixth chromosome are peptide receptors that stimulate T cell response. These peptides, which will enable the recognition of the antigen from which they originate, are loaded into MHC molecules and presented to T cells. Although the principles of loading and delivering peptides are similar for both molecules, the peptide sources and peptide loading mechanisms are different. In addition, class I molecules are expressed in all nucleated cells while class II molecules are expressed only in Antigen Presentation Cells (APC). These differences; It shows that MHC class I is not expressed by exactly the same transcriptional mechanisms as MHC class II. In our article, we aimed to compare the gene expressions of both classes and reveal their similarities and differences. Discussion and Conclusion: A better understanding of the transcriptional mechanisms of MHC molecules will reveal the role of these molecules in diseases more clearly. In our review, we discussed MHC gene regulation mechanisms with presence of existing informations, which is specific to the MHC class, for contribute to future research. Keywords: MHC class I, MHC class II, MHC gene regulation, promoter, SXY module, transcription

Phosphorylation of class I but not class II MHC molecules by membrane-localized protein kinase C

1989 ◽  
Vol 26 (12) ◽  
pp. 1095-1104 ◽  
Author(s):  
Teresa Burke ◽  
Karen Pollok ◽  
William Cushley ◽  
E. Charles Snow
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Class Ii ◽  
Class I ◽  
Mhc Molecules ◽  
Kinase C ◽  
Class Ii Mhc

scholarly journals Characterization of Structural Features Controlling the Receptiveness of Empty Class II MHC Molecules

PLoS ONE ◽  
2011 ◽  
Vol 6 (4) ◽  
pp. e18662 ◽  
Author(s):  
Bernd Rupp ◽  
Sebastian Günther ◽  
Talat Makhmoor ◽  
Andreas Schlundt ◽  
Katharina Dickhaut ◽  
...  
Keyword(s):  
Class Ii ◽  
Structural Features ◽  
Mhc Molecules ◽  
Class Ii Mhc

Mutations of class II MHC molecules

1987 ◽  
Vol 8 (9) ◽  
pp. 274-279 ◽  
Author(s):  
Laurie H. Glimcher ◽  
Irwin J. Griffith
Keyword(s):  
Class Ii ◽  
Mhc Molecules ◽  
Class Ii Mhc

Measuring the capacity of peptides to bind class II MHC molecules and act asTCR antagonists

1996 ◽  
pp. 647-667
Author(s):  
Alessandro Sette ◽  
John Sidney ◽  
Jeff Alexander ◽  
Howard M. Grey
Keyword(s):  
Class Ii ◽  
Mhc Molecules ◽  
Class Ii Mhc

The tetramer model: a new view of class II MHC molecules in antigenic presentation to T cells

1997 ◽  
Vol 50 (5) ◽  
pp. 421-428 ◽  
Author(s):  
E. Pareja ◽  
R. Tobes ◽  
J. Martin ◽  
A. Nieto
Keyword(s):  
T Cells ◽  
Class Ii ◽  
Mhc Molecules ◽  
Class Ii Mhc ◽  
New View

PREDICTING PEPTIDE INTERACTIONS WITH MODEL CLASS II MHC STRUCTURES

2005 ◽  
Vol 14 (04) ◽  
pp. 561-575
Author(s):  
MARTIN T. SWAIN ◽  
ANTHONY J. BROOKS ◽  
GRAHAM J. L. KEMP
Keyword(s):  
Comparative Modeling ◽  
3D Models ◽  
Class Ii ◽  
Mhc Molecules ◽  
Automated Method ◽  
Class Ii Mhc ◽  
Peptide Interactions ◽  
Peptide Binding Groove ◽  
Binding Groove ◽  
Chain Conformations

An automated method for constructing 3D models of class II MHC structures that uses constraint logic programming to select side-chain conformations is described. This method follows a comparative modeling approach in basing the model structures on experimentally determined MHC-peptide structures, but it uses constraints to ease open the peptide binding groove so that the modeled MHC structure is a less specific fit for the co-crystallized peptide in the starting structure. The resulting models are used by a "peptide threading" program that attempts to predict peptides from a protein sequence that will bind strongly to particular MHC alleles. Our results indicate that MHC models that have been constructed in this way enable the peptide threading program to make binding predictions that are comparable with those obtained when using experimentally determined MHC structures, suggesting that a combined modeling and peptide threading approach is worth pursuing for MHC molecules for which experimentally determined structures are not available.

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