scholarly journals Inhibition of Abcg2 transporter on primitive hematopoietic stem cells by All-trans retinoic acid increases sensitivity to anthracycline

2010 ◽  
Vol 30 (1) ◽  
pp. 55-62 ◽  
Author(s):  
Lawrence Lein ◽  
Yasuo Nagai ◽  
Yo Mabuchi ◽  
Sadafumi Suzuki ◽  
Satoru Morikawa ◽  
...  
Keyword(s):  
Stem Cells ◽  
Retinoic Acid ◽  
Hematopoietic Stem Cells ◽  
Hematopoietic Stem ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

All-trans retinoic acid enhances the long-term repopulating activity of cultured hematopoietic stem cells

Blood ◽  
2000 ◽  
Vol 95 (2) ◽  
pp. 470-477 ◽  
Author(s):  
Louise E. Purton ◽  
Irwin D. Bernstein ◽  
Steven J. Collins
Keyword(s):  
Stem Cells ◽  
Retinoic Acid ◽  
Stem Cell Differentiation ◽  
Potent Inducer ◽  
Hematopoietic Stem ◽  
Trans Retinoic Acid ◽  
Liquid Suspension ◽  
All Trans Retinoic Acid ◽  
Cells Cultured

The retinoic acid receptor (RAR) agonist, all-trans retinoic acid (ATRA), is a potent inducer of terminal differentiation of malignant promyelocytes, but its effects on more primitive hematopoietic progenitors and stem cells are less clear. We previously reported that pharmacologic levels (1 μmol) of ATRA enhanced the generation of colony-forming cell (CFC) and colony-forming unit-spleen (CFU-S) in liquid suspension cultures of lin− c-kit+ Sca-1+ murine hematopoietic precursors. In this study, we further investigated the effects of ATRA as well as an RAR antagonist, AGN 193109, on the generation of transplantable cells, including pre–CFU-S, short-term repopulating stem cells (STRCs), and long-term repopulating stem cells (LTRCs). ATRA enhanced the ex vivo maintenance and production of competitive repopulating STRCs and LTRCs from lin− c-kit+ Sca-1+ cells cultured in liquid suspension for 14 days. In addition, ATRA prevented the differentiation of these primitive stem cells into more mature pre–CFU-S during the 14 days of culture. In marked contrast, lin− c-kit+ Sca-1+ cells cultured with AGN 193109 for 7 days had virtually no short- or long-term repopulating ability, but displayed an approximately 6-fold increase in the pre–CFU-S population. The data suggest that the RAR agonist ATRA enhances the maintenance and self-renewal of short- and long-term repopulating stem cells. In contrast, the RAR antagonist AGN 193109 abrogates reconstituting ability, most likely by promoting the differentiation of the primitive stem cells. These results imply an important and unexpected role of retinoids in regulating hematopoietic stem cell differentiation.

scholarly journals Arsenic but not all-trans retinoic acid overcomes the aberrant stem cell capacity of PML/RAR -positive leukemic stem cells

Haematologica ◽  
2007 ◽  
Vol 92 (3) ◽  
pp. 323-331 ◽  
Author(s):  
X. Zheng ◽  
A. Seshire ◽  
B. Ruster ◽  
G. Bug ◽  
T. Beissert ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Retinoic Acid ◽  
Leukemic Stem Cells ◽  
Trans Retinoic Acid ◽  
Cell Capacity ◽  
All Trans Retinoic Acid

scholarly journals The effect of all‐trans retinoic acid (ATRA) and mesenchymal stem cells (MSCs) transplantation on increased expression of Foxp3 and IL‐10

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Sun‐Young Ju ◽  
Kyung‐Ah Cho ◽  
Yun‐Jae Jung ◽  
Su‐Jin Cho ◽  
Kyung‐Ha Ryu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Retinoic Acid ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

Low-dose all-trans retinoic acid enhances cytotoxicity of cisplatin and 5-fluorouracil on CD44+ cancer stem cells

2015 ◽  
Vol 74 ◽  
pp. 243-251 ◽  
Author(s):  
Nowruz Najafzadeh ◽  
Mohammad Mazani ◽  
Asadollah Abbasi ◽  
Faris Farassati ◽  
Mojtaba Amani
Keyword(s):  
Stem Cells ◽  
Retinoic Acid ◽  
Cancer Stem Cells ◽  
Low Dose ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid
Sign in / Sign up

Export Citation Format

Share Document