scholarly journals Znaczenie małych i œśrednich przedsiębiorstw w Polsce po 2000 r.

2008 ◽  
Vol 4 ◽  
pp. 92-109
Author(s):  
Janina Pach
Keyword(s):  
High Efficiency ◽  
Typical Feature ◽  
Business Environment ◽  
Added Value ◽  
High Rate ◽  
Small Enterprises ◽  
Basic Part ◽  
Industrial Processing ◽  
High Level ◽  
Short Time

Small and middle enterprises (SME) are the basic part of the economy in European Unionincluding Poland. Typical feature of them are: high level of flexibility in adaptation to the chan-ges in business environment, strong motivation of entrepreneurs because of the relation betweenprofitability of an enterprise and income of its owner, high efficiency of prospering of SME thatcorresponds to the big financial discipline that dominates in SME sector and low absorptionof capital in the production areas.All these characteristics cause SME sector plays very important role in increasing GrossDomestic Product and added value as well as in increasing the employment. In 2004 the numberof active enterprises of this sector in Poland was estimated to over 1 690 000 which was the99,8% of all enterprises in this country. The number of employees in Polish SME sector in 2005was about 8234,1 that was over 71% of total number of employees working in all the enterprises.Moreover, in 2005 the SME sector generated 47,7% of gross domestic product and 54,2% of ad-ded value. It should be emphasized that importance of micro, middle and small enterprises wasdifferent in particular sectors of economy like: industrial processing, trade, constructions, ho-tels and restaurants, transport etc.Unfortunately, some problems occurred in development of SME sector, for example: thedecreasing number of active enterprises in total number of registered enterprises, low innovativeness of Polish middle and small enterprises, short time of life, high rate of employment in “thegrey zone”. It shows the importance of supporting this sector by national or local governmentunder the auspices of EU which formulated the rules of common politics for SME sector. You canfind these regulations in common European SME Policy and European Competition Policy. It isnecessary to remove all barriers to the SME sector progress by reducing off-pay costs, decre-asing taxes, limiting number of concessions and certificates of approval.

scholarly journals Introduction of the transposable element mariner into the germline of Drosophila melanogaster.

Genetics ◽  
1991 ◽  
Vol 128 (2) ◽  
pp. 303-310 ◽  
Author(s):  
D Garza ◽  
M Medhora ◽  
A Koga ◽  
D L Hartl
Keyword(s):  
Drosophila Melanogaster ◽  
Transposable Element ◽  
High Efficiency ◽  
P Element ◽  
High Rate ◽  
Position Effects ◽  
Eye Color ◽  
Dosage Effects ◽  
High Level ◽  
Pole Plasm

Abstract A chimeric white gene (wpch) and other constructs containing the transposable element mariner from Drosophila mauritiana were introduced into the germline of Drosophila melanogaster using transformation mediated by the P element. In the absence of other mariner elements, the wpch allele is genetically stable in both germ cells and somatic cells, indicating that the peach element (i.e., the particular copy of mariner inserted in the wpch allele) is inactive. However, in the presence of the active element Mos1, the wpch allele reverts, owing to excision of the peach element, yielding eye-color mosaics and a high rate of germline reversion. In strains containing Mos1 virtually every fly is an eye-color mosaic, and the rate of wpch germline reversion ranges from 10 to 25%, depending on temperature. The overall rates of mariner excision and transposition are approximately sixfold greater than the rates in comparable strains of Drosophila simulans. The activity of the Mos1 element is markedly affected by position effects at the site of Mos1 insertion. In low level mosiac lines, dosage effects of Mos1 are apparent in the heavier level of eye-color mosaicism in Mos1 homozygotes than in heterozygotes. However, saturation occurs in high level mosaic lines, and then dosage effects are not observed. A pBluescribe M13+ plasmid containing Mos1 was injected into the pole plasm of D. melanogaster embryos, and the Mos1 element spontaneously integrated into the germline at high efficiency. These transformed strains of D. melanogaster presently contain numerous copies of mariner and may be useful in transposon tagging and other applications.

scholarly journals Valorization of Kiwi by-Products for the Recovery of Bioactive Compounds: Circular Economy Model

Proceedings ◽  
2020 ◽  
Vol 70 (1) ◽  
pp. 9
Author(s):  
Franklin Chamorro ◽  
María Carpena ◽  
Bernabé Nuñez-Estevez ◽  
Miguel A. Prieto ◽  
Jesus Simal-Gandara
Keyword(s):  
Bioactive Compounds ◽  
Circular Economy ◽  
Agricultural Production ◽  
Organic Waste ◽  
Antimicrobial Activities ◽  
Added Value ◽  
Economic Returns ◽  
Industrial Processing ◽  
Pharmaceutical Industries ◽  
By Products

Currently, agricultural production generates large amounts of organic waste, both from the maintenance of farms and crops, and from the industrialization of the product. Generally, these wastes are accumulated in landfills or burned, sometimes causing environmental problems. However, many scientific studies suggest that these residues are rich in bioactive compounds, so these matrices could be revalued for their use in food, cosmetic, or pharmaceutical industries. In this way, the circular and sustainable economy is favored, while obtaining products with high added value. In this case, this approach is applied to the residues generated from kiwi production, since numerous studies have shown the high content of kiwi in bioactive compounds of interest, such as phenolic compounds, vitamins, and carotenoids. These compounds have been reported for their antioxidant, anti-inflammatory, and antimicrobial activities, among other beneficial properties for health such as its use as prebiotic. Therefore, this article reviews the potential of residues derived from industrial processing and agricultural maintenance of kiwi as promising matrices for the development of new nutraceutical, cosmetic, or pharmacological products, obtaining, at the same time, economic returns and a reduction of the environmental impact of this industry, attaching it to the perspective of the circular economy.

scholarly journals Ultrafast presodiation of graphene anodes for high‐efficiency and high‐rate s odium‐ion storage

InfoMat ◽  
2021 ◽  
Author(s):  
Ganyu Zheng ◽  
Qiaowei Lin ◽  
Jiabin Ma ◽  
Jun Zhang ◽  
Yan‐Bing He ◽  
...  
Keyword(s):  
High Efficiency ◽  
High Rate ◽  
Ion Storage

scholarly journals The YadA Protein of Yersinia pseudotuberculosis Mediates High-Efficiency Uptake into Human Cells under Environmental Conditions in Which Invasin Is Repressed

2002 ◽  
Vol 70 (9) ◽  
pp. 4880-4891 ◽  
Author(s):  
Julia Eitel ◽  
Petra Dersch
Keyword(s):  
Extracellular Matrix ◽  
Mammalian Cells ◽  
Yersinia Pseudotuberculosis ◽  
High Efficiency ◽  
Environmental Parameters ◽  
Infection Process ◽  
Nutrient Concentrations ◽  
Integrin Receptors ◽  
Uptake Process ◽  
High Level

ABSTRACT The YadA protein is a major adhesin of Yersinia pseudotuberculosis that promotes tight adhesion to mammalian cells by binding to extracellular matrix proteins. In this study, we first addressed the possibility of competitive interference of YadA and the major invasive factor invasin and found that expression of YadA in the presence of invasin affected neither the export nor the function of invasin in the outer membrane. Furthermore, expression of YadA promoted both bacterial adhesion and high-efficiency invasion entirely independently of invasin. Antibodies against fibronectin and β1 integrins blocked invasion, indicating that invasion occurs via extracellular-matrix-dependent bridging between YadA and the host cell β1 integrin receptors. Inhibitor studies also demonstrated that tyrosine and Ser/Thr kinases, as well as phosphatidylinositol 3-kinase, are involved in the uptake process. Further expression studies revealed that yadA is regulated in response to several environmental parameters, including temperature, ion and nutrient concentrations, and the bacterial growth phase. In complex medium, YadA production was generally repressed but could be induced by addition of Mg2+. Maximal expression of yadA was obtained in exponential-phase cells grown in minimal medium at 37°C, conditions under which the invasin gene is repressed. These results suggest that YadA of Y. pseudotuberculosis constitutes another independent high-level uptake pathway that might complement other cell entry mechanisms (e.g., invasin) at certain sites or stages during the infection process.

scholarly journals Multi-Sensor Fusion for Aerial Robots in Industrial GNSS-Denied Environments

2021 ◽  
Vol 11 (9) ◽  
pp. 3921
Author(s):  
Paloma Carrasco ◽  
Francisco Cuesta ◽  
Rafael Caballero ◽  
Francisco J. Perez-Grau ◽  
Antidio Viguria
Keyword(s):  
Sensor Fusion ◽  
Computational Efficiency ◽  
Probabilistic Approach ◽  
Laser Scanner ◽  
Industrial Applications ◽  
Experimental Results ◽  
Added Value ◽  
Aerial Robots ◽  
3D Localization ◽  
High Level

The use of unmanned aerial robots has increased exponentially in recent years, and the relevance of industrial applications in environments with degraded satellite signals is rising. This article presents a solution for the 3D localization of aerial robots in such environments. In order to truly use these versatile platforms for added-value cases in these scenarios, a high level of reliability is required. Hence, the proposed solution is based on a probabilistic approach that makes use of a 3D laser scanner, radio sensors, a previously built map of the environment and input odometry, to obtain pose estimations that are computed onboard the aerial platform. Experimental results show the feasibility of the approach in terms of accuracy, robustness and computational efficiency.

scholarly journals High-Intensity Focused Ultrasound Circular Cyclocoagulation in Glaucoma: A Step Forward for Cyclodestruction?

2017 ◽  
Vol 2017 ◽  
pp. 1-14 ◽  
Author(s):  
Rodolfo Mastropasqua ◽  
Vincenzo Fasanella ◽  
Alessandra Mastropasqua ◽  
Marco Ciancaglini ◽  
Luca Agnifili
Keyword(s):  
High Intensity ◽  
Ciliary Body ◽  
Focused Ultrasound ◽  
Current Knowledge ◽  
High Intensity Focused Ultrasound ◽  
High Rate ◽  
Dose Effect ◽  
Computer Assisted ◽  
Refractory Glaucoma ◽  
High Level

The ciliary body ablation is still considered as a last resort treatment to reduce the intraocular pressure (IOP) in uncontrolled glaucoma. Several ablation techniques have been proposed over the years, all presenting a high rate of complications, nonselectivity for the target organ, and unpredictable dose-effect relationship. These drawbacks limited the application of cyclodestructive procedures almost exclusively to refractory glaucoma. High-intensity focused ultrasound (HIFU), proposed in the early 1980s and later abandoned because of the complexity and side effects of the procedure, was recently reconsidered in a new approach to destroy the ciliary body. Ultrasound circular cyclocoagulation (UC3), by using miniaturized transducers embedded in a dedicated circular-shaped device, permits to selectively treat the ciliary body in a one-step, computer-assisted, and non-operator-dependent procedure. UC3 shows a high level of safety along with a predictable and sustained IOP reduction in patients with refractory glaucoma. Because of this, the indication of UC3 was recently extended also to naïve-to-surgery patients, thus reconsidering the role and timing of ciliary body ablation in the surgical management of glaucoma. This article provides a review of the most used cycloablative techniques with particular attention to UC3, summarizing the current knowledge about this procedure and future possible developments.

High Efficiency Combined Aggregate – Submerged Combustion Melter–Electric Furnace for Vitrification of High-Level Radioactive Wastes

2004 ◽  
Author(s):  
L. S. Pioro ◽  
I. L. Pioro
Keyword(s):  
Electric Furnace ◽  
High Efficiency ◽  
High Capacity ◽  
Main Idea ◽  
Melting Process ◽  
Radioactive Wastes ◽  
Single Stage ◽  
Interface Surface ◽  
High Level ◽  
Submerged Combustion

It is well known that high-level radioactive wastes (HLRAW) are usually vitrified inside electric furnaces. Disadvantages of electric furnaces are their low melting capacity and restrictions on charge preparation. Therefore, a new concept for a high efficiency combined aggregate – submerged combustion melter (SCM)–electric furnace was developed for vitrification of HLRAW. The main idea of this concept is to use the SCM as the primary high-capacity melting unit with direct melt drainage into an electric furnace. The SCM employs a single-stage method for vitrification of HLRAW. The method includes concentration (evaporation), calcination, and vitrification of HLRAW in a single-stage process inside a melting chamber of the SCM. Specific to the melting process is the use of a gas-air or gas-oxygen-air mixture with direct combustion inside a melt. Located inside the melt are high-temperature zones with increased reactivity of the gas phase, the existence of a developed interface surface, and intensive mixing, leading to intensification of the charge melting and vitrification process. The electric furnace clarifies molten glass, thus preparing the high-quality melt for subsequent melt pouring into containers for final storage.

scholarly journals Isothermal and non-isothermal kinetics of hydrolysis of 1-[2-(2- pentyloxyphenylcarbamoyloxy)-(2-methoxymethyl)-ethyl]- perhydroazepinium chloride (BK 129)

2013 ◽  
Vol 60 (2) ◽  
pp. 43-48
Author(s):  
Stankovičová M. ◽  
Bezáková Ž. ◽  
Beňo P. ◽  
Húšťavová P.
Keyword(s):  
Biological Activity ◽  
Alkaline Hydrolysis ◽  
Functional Group ◽  
Isothermal Kinetics ◽  
Basic Part ◽  
Buffer Solutions ◽  
Kinetics Of Hydrolysis ◽  
Short Time ◽  
Kinetics Of ◽  
Hydrolysis Of

Abstract The substance BK 129 - 1-[2-(2-pentyloxyphenylcarbamoyloxy)-(2-methoxymethyl)-ethyl]-perhydroazepinium chloride was prepared in terms of influence of the connecting chain between the carbamate functional group and the basic part of molecule on biological activity. Such a structural feature is important with regard to its stability. In this work we determined the rate constants of alkaline hydrolysis of this compound at increased temperature under isothermal and non-isothermal conditions. The hydrolysis was also performed in buffer solutions with the purpose of evaluating its stability. Non-isothermal tests of stability enable to reduce the number of analyses. The necessary data for stability of compound are in this way achieved in a short time.

COMPARATIVE ANALYSIS OF INTERNATIONAL STANDARDS IN THE FIELD OF NON-FINANCIAL REPORTING AND THE PRACTICE OF THEIR APPLICATION

2021 ◽  
Vol 2 (4) ◽  
pp. 146-152
Author(s):  
E. V. ANDRIANOVA ◽  
◽  
P. S. SHCHERBACHENKO ◽  
Keyword(s):  
Financial Reporting ◽  
Financial Statements ◽  
Business Environment ◽  
International Standards ◽  
Positive Trend ◽  
Financial Indicators ◽  
Additional Tool ◽  
Foreign Companies ◽  
High Level ◽  
Source Of Information

This article discusses and analyzes the most popular standards of non-financial reporting, which has a significant impact on the transformation of the business environment. Already, domestic and foreign companies with a high level of responsibility are beginning to publish non-financial statements in addition to financial statements, which is an additional tool for communication with stakeholders and a new source of information about their activities. To date, reports of this type are clearly unregulated, there are no verification standards, however, there is already a positive trend and the active introduction of non-financial indicators in the regular reporting of companies.

708 A NEW DIAGNOSTIC PARADIGM FOR LARYNGOPHARYNGEAL REFLUX DISEASE: CORRELATION OF IMPEDANCE-PH MONITORING AND DIGITAL REFLUX SCINTIGRAPHY RESULTS

2021 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Jin-soo Park ◽  
Oleksandr Khoma ◽  
Hans Van Der Wall ◽  
Gregory Falk
Keyword(s):  
Laryngopharyngeal Reflux ◽  
Ph Monitoring ◽  
Acid Reflux ◽  
High Rate ◽  
High Yield ◽  
Time Activity ◽  
Proximal Esophagus ◽  
Laryngopharyngeal Reflux Disease ◽  
High Level ◽  
No Gold Standard

Abstract   No gold-standard investigation exists for laryngopharyngeal reflux (LPR). Multichannel intraluminal impedance (MII)-pH testing has uncertain utility in LPR. Meanwhile, reflux scintigraphy allows immediate and delayed visualisation of tracer reflux in the esophagus, pharynx, and lungs. The present study aimed to correlate MII-pH and scintigraphic reflux results in patients with primary LPR. Methods Consecutive patients with LPR underwent MII-pH and scintigraphic reflux studies. Abnormal values for MII-pH results were defined from existing literature. MII-pH and scintigraphic data were correlated. Results 105 patients with LPR (31 males (29.5%), median age 60 years (range: 20–87)) were studied. Scintigraphic reflux was seen in the pharynx in 94 (90.4%), and in the proximal esophagus in 94 (90.4%). Delayed scintigraphic contamination of the pharynx was seen in 101 patients (96.2%) and in the lungs of 56 patients (53.3%). Abnormal reflux was seen in the distal esophagus in 12.4%, proximal esophagus in 25.7%, and in the pharynx in 82.9%. Patients with poor scintigraphic clearance had higher Demeester scores (p = 0.043), more proximal reflux episodes (p = 0.046), more distal acid reflux episodes (p = 0.023), and longer bolus clearance times (p = 0.002). Conclusion Reflux scintigraphy has a high yield in LPR patients. Scintigraphic time-activity curves correlated with validated MII-pH results. A high rate of pulmonary microaspiration was found in LPR patients. This study demonstrated a high level of pharyngeal contamination by scintigraphy and MII-pH, which supports the use of digital reflux scintigraphy in diagnosing LPR.

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