scholarly journals A present state and clinical problems of long term outcome of patients with acquired hemophilia A in our hospital

2016 ◽  
Vol 27 (1) ◽  
pp. 64-69 ◽  
Author(s):  
Yoshinobu SEKI ◽  
Shukuko MIYAKOSHI
Keyword(s):  
Present State ◽  
Hemophilia A ◽  
Acquired Hemophilia A ◽  
Acquired Hemophilia ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Clinical Problems

scholarly journals Anti-factor IXa/X bispecific antibody ACE910 prevents joint bleeds in a long-term primate model of acquired hemophilia A

Blood ◽  
2014 ◽  
Vol 124 (20) ◽  
pp. 3165-3171 ◽  
Author(s):  
Atsushi Muto ◽  
Kazutaka Yoshihashi ◽  
Minako Takeda ◽  
Takehisa Kitazawa ◽  
Tetsuhiro Soeda ◽  
...  
Keyword(s):  
Nonhuman Primates ◽  
Bispecific Antibody ◽  
Hemophilia A ◽  
Acquired Hemophilia A ◽  
Acquired Hemophilia ◽  
Primate Model ◽  
Factor Ixa ◽  
Key Points

Key Points A long-term acquired hemophilia A model expressing spontaneous joint bleeds and other bleeds was newly established in nonhuman primates. Weekly SC dose of the anti-FIXa/X bispecific antibody ACE910 prevented joint bleeds and other bleeds in the primate hemophilia A model.

Long-term outcomes in the treatment of acquired hemophilia A

2020 ◽  
Vol 31 (1) ◽  
pp. 43-47
Author(s):  
Justin Loloi ◽  
Morgan K. Moroi ◽  
Natthapol Songdej ◽  
Hamid A. Al-Mondhiry
Keyword(s):  
Hemophilia A ◽  
Long Term Outcomes ◽  
Acquired Hemophilia A ◽  
Acquired Hemophilia

scholarly journals A modeling approach to evaluate long-term outcome of prophylactic and on demand treatment strategies for severe hemophilia A

Haematologica ◽  
2011 ◽  
Vol 96 (5) ◽  
pp. 738-743 ◽  
Author(s):  
K. Fischer ◽  
M. E. Pouw ◽  
D. Lewandowski ◽  
M. P. Janssen ◽  
H. M. van den Berg ◽  
...  
Keyword(s):  
Hemophilia A ◽  
Treatment Strategies ◽  
Severe Hemophilia ◽  
Term Outcome ◽  
Long Term Outcome ◽  
On Demand ◽  
Modeling Approach

scholarly journals Acquired Hemophilia A successfully treated with rituximab

2015 ◽  
Vol 7 ◽  
pp. e2015024 ◽  
Author(s):  
Giovanni D'Arena ◽  
Elvira Grandone ◽  
Matteo Nicola Dario Di Minno ◽  
Pellegrino Musto ◽  
Giovanni Di Minno
Keyword(s):  
Therapeutic Strategy ◽  
Hemophilia A ◽  
Prolonged Administration ◽  
Acquired Hemophilia A ◽  
Acquired Hemophilia ◽  
Precise Position ◽  
Initial Resistance ◽  
Anti Cd20 ◽  
Hematological Remission

Acquired hemophilia A (AHA) is a rare bleeding disorder due to the development of specific autoantibodies against factor VIII. The anti-CD20 monoclonal antibody Rituximab has been proven to be effective in  obtaining a long-term suppression of inhibitors of AHA,  besides other immunosuppressive standard treatments. Here we describe a case of idiopathic AHA in a 60-year old man successfully treated with rituximab. He showed a complete clinical response with  a normalization of clotting  parameters after 5 weekly courses of rituximab given at a dose of 375 mg/sqm. , but after stopping rituximab, an initial worsening of coagulation  parameters  induced the addition of 3 further courses. At present, the patient is in complete clinical and hematological remission after 200 days.  This case confirms that Rituximab may be a safe and useful tool to treat AHA and, a prolonged administration can overcome the initial resistance. However, the precise position of this drug in the therapeutic strategy (first or second-line, alone or in combination with other drugs) remains to be established and warrants further investigation.

scholarly journals Extracorporeal Treatment for the Acute und Long-Term Outcome of Patients with Life-Threatening Acquired Hemophilia

2012 ◽  
Vol 39 (4) ◽  
pp. 264-270 ◽  
Author(s):  
Heike Zeitler ◽  
Gudrun Ulrich-Merzenich ◽  
Darius Panek ◽  
Georg Goldmann ◽  
Natascha Vidovic ◽  
...  
Keyword(s):  
Acquired Hemophilia ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Extracorporeal Treatment ◽  
Life Threatening

Long-term outcome of treatment with cyclosporine IV for patients with intractable ulcerative colitis

2001 ◽  
Vol 120 (5) ◽  
pp. A624-A624 ◽  
Author(s):  
J ARTS ◽  
M ZEEGERS ◽  
G DHAENS ◽  
G VANASSCHE ◽  
M HIELE ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Term Outcome ◽  
Long Term Outcome
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