Clinical and Public Health Implications of HIV-1 Genetic Diversity and Drug Resistance Mutations in Angola: A Systematic Review

Aids Reviews ◽  
2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Cruz S. Sebastião ◽  
Joana Morais ◽  
Miguel Brito
Keyword(s):  
Public Health ◽  
Systematic Review ◽  
Genetic Diversity ◽  
Drug Resistance ◽  
Resistance Mutations ◽  
Health Implications ◽  
Drug Resistance Mutations ◽  
Hiv 1

scholarly journals HIV-1 genetic diversity and drug resistance mutations in the northern Brazilian region

2021 ◽  
pp. 101596
Author(s):  
Myuki Esashika Crispim ◽  
Monica Nogueira da Guarda Reis ◽  
Mariane Martins de Araujo Stefani
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Resistance Mutations ◽  
Drug Resistance Mutations ◽  
Hiv 1

Alarming rate of transmitted drug resistance mutations and genetic diversity in newly HIV-1-infected patients in Benin

2020 ◽  
Author(s):  
Edmond Tchiakpe ◽  
Rene K Keke ◽  
Nicole Vidal ◽  
Clément Ahoussinou ◽  
Olga Sekpe ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Resistance Rate ◽  
Transmitted Drug Resistance ◽  
Resistance Mutations ◽  
High Genetic Diversity ◽  
Drug Resistance Mutations ◽  
Primary Drug Resistance ◽  
Hiv 1 ◽  
Primary Drug

Abstract BackgroundSeventeen years after the start of the IBAARV (Beninese initiative for access to antiretrovirals), transmitted drug resistance mutations in ARV naïve patients and HIV-1 genetic diversity were investigated in Benin.Methods353 plasma samples were collected between October and December 2017 in nineteen facilities care in Benin from HIV-1 positive and ARV naive individuals. Pol (protease + partial RT) region was amplified and sequenced in 248 samples.ResultsDrug resistance mutations were detected in (27/248; 10.9%) according to the WHO SDRM 2009 list, with predominance of mutations directed to NNRTIs drugs (24/248; 10%).Phylogenetic and recombination analyses showed a predominance of CRF02_AG strains (165/248; 66.5%) and a high genetic diversity with five other variants and 39 URFs (15.7%) which contained portions of strains that co-circulate in Benin. Eight recent transmission chains revealed active ongoing transmission of HIV-1 strains among ARV naïve patients.ConclusionsOur study showed a high primary drug resistance rate and a complex genetic diversity. Regular monitoring of primary drug resistance is required to adapt HIV-1 treatment strategies and adoption of new WHO recommendations in Benin.

scholarly journals HIV-1 Genetic Diversity and Drug Resistance Mutations Among Treatment-Naive Adult Patients in Suriname

2016 ◽  
Vol 32 (12) ◽  
pp. 1223-1228 ◽  
Author(s):  
Firoz Abdoel Wahid ◽  
Rachel Sno ◽  
Edith Darcissac ◽  
Anne Lavergne ◽  
Malti R. Adhin ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Adult Patients ◽  
Resistance Mutations ◽  
Drug Resistance Mutations ◽  
Treatment Naïve ◽  
Hiv 1

HIV-1 Genetic Diversity and Transmitted Drug Resistance Mutations in Female Sex Workers from a Brazilian Municipality in the Amazon Region

2020 ◽  
Vol 36 (2) ◽  
pp. 99-100 ◽  
Author(s):  
Luana Mota da Costa ◽  
Paula Cristina R. Frade ◽  
Lucinaldo da Silva Blandtt ◽  
Gláucia C. Silva-Oliveira ◽  
Luiz Fernando A. Machado ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Sex Workers ◽  
Female Sex Workers ◽  
Amazon Region ◽  
Transmitted Drug Resistance ◽  
Resistance Mutations ◽  
Drug Resistance Mutations ◽  
Female Sex ◽  
Hiv 1

scholarly journals Evolution of genetic diversity and drug resistance mutations in HIV-1 among untreated patients from Mali between 2005 and 2006

2008 ◽  
Vol 62 (3) ◽  
pp. 456-463 ◽  
Author(s):  
A. Derache ◽  
A.-I. Maiga ◽  
O. Traore ◽  
A. Akonde ◽  
M. Cisse ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Resistance Mutations ◽  
Drug Resistance Mutations ◽  
Hiv 1

scholarly journals Moderate rate of transmitted resistance mutations to antiretrovirals and genetic diversity in newly HIV-1 patients diagnosed in Benin.

2020 ◽  
Author(s):  
EDMOND TCHIAKPE ◽  
Rene K Keke ◽  
Nicole Vidal ◽  
Clément Ahoussinou ◽  
Olga Sekpe ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Treatment Strategies ◽  
Transmitted Drug Resistance ◽  
Resistance Mutations ◽  
High Genetic Diversity ◽  
Drug Resistance Mutations ◽  
Primary Drug Resistance ◽  
Hiv 1 ◽  
Primary Drug

Abstract Objective Seventeen years after the start of the IBAARV (Beninese initiative for access to antiretrovirals), transmitted drug resistance mutations in ARV-naïve patients and HIV-1 genetic diversity were investigated in Benin. Results Drug resistance mutations were detected in (27/248; 10.9%) according to the WHO SDRM 2009 list, with a predominance of mutations directed against NNRTIs drugs (24/248; 10%). Phylogenetic and recombination analyses showed a predominance of CRF02_AG strains (165/248; 66.5%) and a high genetic diversity with five other variants and 39 URFs (15.7%) which contained portions of strains that co-circulate in Benin. Eight recent transmission chains revealed active ongoing transmission of HIV-1 strains among ARV-naïve patients.Our study showed a moderate primary drug resistance mutations rate and also provided recent data on the HIV-1 variants that circulate in Benin. Regular monitoring of primary drug resistance is required to adapt HIV-1 treatment strategies and adoption of new WHO recommendations in Benin.

scholarly journals Moderate rate of transmitted resistance mutations to antiretrovirals and genetic diversity in newly HIV-1 patients diagnosed in Benin.

2020 ◽  
Author(s):  
EDMOND TCHIAKPE ◽  
Rene K Keke ◽  
Nicole Vidal ◽  
Clément Ahoussinou ◽  
Olga Sekpe ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Treatment Strategies ◽  
Transmitted Drug Resistance ◽  
Resistance Mutations ◽  
High Genetic Diversity ◽  
Drug Resistance Mutations ◽  
Primary Drug Resistance ◽  
Hiv 1 ◽  
Primary Drug

Abstract Objective Seventeen years after the start of the IBAARV (Beninese initiative for access to antiretrovirals), transmitted drug resistance mutations in ARV naïve patients and HIV-1 genetic diversity were investigated in Benin. Results Drug resistance mutations were detected in (27/248; 10.9%) according to the WHO SDRM 2009 list, with a predominance of mutations directed to NNRTIs drugs (24/248; 10%). Phylogenetic and recombination analyses showed a predominance of CRF02_AG strains (165/248; 66.5%) and a high genetic diversity with five other variants and 39 URFs (15.7%) which contained portions of strains that co-circulate in Benin. Eight recent transmission chains revealed active ongoing transmission of HIV-1 strains among ARV naïve patients. Our study showed a moderate primary drug resistance mutations rate and also provided recent data on the HIV-1 variants that circulate in Benin. Regular monitoring of primary drug resistance is required to adapt HIV-1 treatment strategies and adoption of new WHO recommendations in Benin.

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