scholarly journals Clinical and Endoscopic Features in Helicobacter Pylori Infection: Literature Review

2021 ◽  
Vol 22 (1) ◽  
pp. 66-72
Author(s):  
Ghina Tsuraya Salsabila Budiman ◽  
Muhammad Begawan Bestari ◽  
Sri Suryanti
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Functional Dyspepsia ◽  
Epigastric Pain ◽  
False Negative ◽  
Clinical Manifestations ◽  
Helicobacter Pylori Infection ◽  
Gastric Ulcers ◽  
Common Symptom ◽  
Peptic Ulcers

Helicobacter pylori is a common infection worldwide and can cause functional dyspepsia, gastritis, and peptic ulcers, leading to gastric cancer. The very diverse clinical outcomes and symptoms of this infection are difficult to distinguish from one another. Endoscopy is one of the methods used to detect Helicobacter pylori infection. Still, it has various endoscopic features, has the possibility of false-negative results, and requires skill to get the maximum results.This study found that infection can cause various clinical manifestations due to different virulence factors of Helicobacter pylori bacteria. In functional dyspepsia, the patient's most common symptoms are epigastric pain, nausea, and vomiting. In gastritis, Helicobacter pylori infection often causes chronic gastritis with topographic features of pangastritis, and endoscopic features that are usually found are redness, swelling, and regular arrangement of collecting venules (RAC). The most common symptom in peptic ulcers is pain that occurs after eating or at night, and this infection can cause duodenal and gastric ulcers. Currently, the relationship between Helicobacter pylori infection and gastroesophageal reflux disease (GERD) is controversial. In gastric cancer, the most common symptoms are weight loss and repeated vomiting. This infection is more likely to causes intestinal-type gastric cancer.

scholarly journals Helicobacter pylori infection in Iran: demographic, endoscopic and pathological factors

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Seyedeh Amineh Hojati ◽  
Sara Kokabpeyk ◽  
Salma Yaghoubi ◽  
Farahnaz Joukar ◽  
Mehrnaz Asgharnezhad ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Epigastric Pain ◽  
Tap Water ◽  
Clinical Manifestations ◽  
Gastrointestinal Symptoms ◽  
Common Symptom ◽  
Pathological Findings ◽  
Significant Difference ◽  
H Pylori

Abstract Background Helicobacter pylori (H. pylori) infection is the most important risk factor for gastritis and peptic ulcer. However, factors other than H. pylori are involved in its pathogenesis. In the current study, we aimed to compare the clinical manifestations and endoscopic and histopathological findings of patients with and without H. pylori infection. Methods In this cross-sectional study, 233 patients with dyspepsia, referred for endoscopy, were examined regarding the presence of H. pylori infection. During an endoscopic exam, 5 biopsy specimens were taken from the stomach. The criteria for the presence of H. pylori infection was the presence and identification of bacteria in pathology. Two groups of H. pylori-positive and H. pylori-negative patients were compared regarding their demographic, endoscopic, and pathological findings. Results Of 233 patients, 154 (66.1%) were non-smokers, 201 (86.3%) were not alcohol users, and 153 (65.7%) used tap water. The most common symptom, reported in 157 (67.4%) patients, was epigastric pain. There was a significant difference between patients with and without H. pylori infection in terms of the educational status, occupational status, family history of gastrointestinal cancer, and some gastrointestinal symptoms. Also, there was a significant relationship between the endoscopic and pathological findings of patients with H. pylori. Conclusions The results of the present study revealed that H. pylori infection was not associated with sex, alcohol consumption, or non-steroidal anti-inflammatory drug use. The role of H. pylori in the pathophysiology of peptic ulcer was clarified. Also, there was a significant difference in the endoscopic and pathological findings of patients with H. pylori.

Effective Reduction of Gastric Cancer Risk With Regular Use of Nonsteroidal Anti-Inflammatory Drugs in Helicobacter Pylori–Infected Patients

2010 ◽  
Vol 28 (18) ◽  
pp. 2952-2957 ◽  
Author(s):  
Chun-Ying Wu ◽  
Ming-Shiang Wu ◽  
Ken N. Kuo ◽  
Chang-Bi Wang ◽  
Yi-Ju Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Protective Factor ◽  
Nsaid User ◽  
Gastric Ulcers ◽  
Number Needed To Treat ◽  
Peptic Ulcers ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
H Pylori

Purpose Nonsteroidal anti-inflammatory drugs (NSAIDs) play protective roles in gastric carcinogenesis. However, the interaction between NSAIDs and Helicobacter pylori (H pylori) infection and the number needed to treat to prevent gastric cancer remains unclear. Patients and Methods We conducted a nationwide retrospective cohort study based on data from the Taiwan National Health Insurance Database. Hospitalized patients with a primary diagnosis of peptic ulcer disease were selected. Overall, 52,161 patients were divided into non-NSAID user and regular NSAID user cohorts. Standardized incidence ratios (SIRs), cumulative incidences, and hazard ratios (HRs) were calculated. Results Patients with peptic ulcers who never used NSAIDs had higher risk of gastric cancer compared with the general population (SIR, 2.11; 95% CI, 2.07 to 2.15), but regular NSAID use conferred lower risk (SIR, 0.79; 95% CI, 0.77 to 0.81). The protective role of NSAID use was observed in patients with gastric ulcer, but not in patients with non–H pylori-associated duodenal ulcer. On multivariate analysis, regular NSAID use was an independent protective factor for gastric cancer development (HR, 0.79 for each incremental year; P < .001), especially in H pylori-associated patients (HR, 0.52 for each incremental year; P < .001). Among patients with H pylori-infected gastric ulcers, the NNT to prevent a gastric cancer was 50. Conclusion Regular NSAID use may be a feasible way to prevent gastric cancer, at least in patients with gastric ulcers, and especially in H pylori-infected subjects.

scholarly journals Frequency of helicobacter pylori in patients with functional dyspepsia.

2019 ◽  
Vol 26 (08) ◽  
pp. 1261-1265
Author(s):  
Tooba ◽  
Riaz Hussain Awan ◽  
Seema Nayab ◽  
Khadim Hussain Awan ◽  
Faqir Muhammad Awan
Keyword(s):  
Helicobacter Pylori ◽  
Functional Dyspepsia ◽  
Histopathological Examination ◽  
Epigastric Pain ◽  
Helicobacter Pylori Infection ◽  
Cross Sectional ◽  
Male Predominance ◽  
Duration Of Disease ◽  
The Mean ◽  
H Pylori

To evaluate the frequency of Helicobacter pylori in individuals with functional dyspepsia. Study Design: Cross sectional descriptive study. Period: Six months from 01-May-2014 to 31-10-2014. Setting: Liaquat National Hospital, Karachi. Materials and Methods: All the patients between 18 to 70 years of age diagnosed as functional dyspepsia for more than 03 months duration were admitted and evaluated for Helicobacter pylori infection through histopathological examination. Results: Total 121 subjects with functional dyspepsia were screened for Helicobacter pylori infection. The mean ±SD for age of subjects with functional dyspepsia was 41.74±08.87. The mean age ±SD of Helicobacter pylori infected individuals was 40.70±7.82 while the mean ±SD of age in helicobacter pylori negative patients was 40.55±10.63. Majority of the subjects were out-patients, 30-39 years of age with male predominance. The most common duration of disease observed was 6-9 months with epigastric pain and burning the predominant symptoms. The Helicobacter pylori infection was observed in 78(64.4%) individuals, of which 55 were males and 23 were males (p=<0.01). Conclusion: The functional dyspeptic patients are prone to acquire Helicobacter pylori infection therefore present study reported 64.4% prevalence for H. pylori infection with male gender predominance.

Effect of Helicobacter pylori infection on early gastric cancer and gastric adenoma

2001 ◽  
Vol 120 (5) ◽  
pp. A658-A658
Author(s):  
E UMEGAKI ◽  
M TANAKA ◽  
N TAKEUCHI ◽  
K NISHIMURA ◽  
M NANRI ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Early Gastric Cancer ◽  
Helicobacter Pylori Infection ◽  
Gastric Adenoma

A Case of Urticarial Erythema with Early Gastric Cancer and Helicobacter pylori Infection

2007 ◽  
Vol 69 (1) ◽  
pp. 8-10
Author(s):  
Ritsuko KANO ◽  
Yusuke YOSHIZAWA ◽  
Seiji KAWANA ◽  
Taku TSUKUI
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Early Gastric Cancer ◽  
Helicobacter Pylori Infection
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